Search: AGOSR

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An Adagio for Viruses, Played Out on Ancient Dna.

Toni,de-Dios; Christiana L,Scheib; Charlotte J,Houldcroft

Studies of ancient DNA have transformed our understanding of human evolution. Paleogenomics can also reveal historic and prehistoric agents of disease, including endemic, epidemic, and pandemic pathogens. Viruses-and in...

Evolution Virology Population Genomics Adna Paleogenomics Ancient Biomolecules Humans Viruses Dna Genomics Paleontology Dna Ancient

Published by: Genome biology and evolution

Published on: Apr 17, 2023

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Structures of Apo Cas12a and Its Complex with Crrna and Dna Reveal the Dynamics of Ternary Complex Formation and Target Dna Cleavage.

Li,Jianwei; Chacko,Jobichen; Satoru,Machida; Sun,Meng; Randy J,Read; Chen,Hongying; Shi,Jian; Yuren Adam,Yuan; J,Sivaraman

Cas12a is a programmable nuclease for adaptive immunity against invading nucleic acids in CRISPR-Cas systems. Here, we report the crystal structures of apo Cas12a from Lachnospiraceae bacterium MA2020 (Lb2) and the...

Bacterial Proteins Dna Rna Dna Cleavage Crispr-Cas Systems Rna Guide Crispr-Cas Systems

Published by: PLoS biology

Published on: Apr 14, 2023

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Dynamic Light Scattering Based Microrheology of End-Functionalised Triblock Copolymer Solutions.

Ren,Liu; Alessio,Caciagli; Jiaming,Yu; Xiaoying,Tang; Rini,Ghosh; Erika,Eiser

Dna Dynamic Light Scattering Microrheology Telechelic Polymers Transient Hydrogels Competing Self-Assembly Triblock-Copolymer

Published by: Polymers

Published on: Mar 14, 2023

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Evolution and Dispersal of Snakes Across the Cretaceous-Paleogene Mass Extinction.

Catherine G,Klein; Davide,Pisani; Daniel J,Field; Rebecca,Lakin; Matthew A,Wills; Nicholas R,Longrich

Mass extinctions have repeatedly shaped global biodiversity. The Cretaceous-Paleogene (K-Pg) mass extinction caused the demise of numerous vertebrate groups, and its aftermath saw the rapid diversification of surviving mammals...

Animals Birds Fishes Mammals Snakes Biodiversity Phylogeny Fossils History Ancient Genetic Speciation Extinction Biological Amphibians Phylogeography Animal Distribution Dna Ancient

Published by: Nature Communications

Published on: Oct 18, 2021

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Climatic Windows for Human Migration Out of Africa in the Past 300,000 Years.

Robert M,Beyer; Mario,Krapp; Anders,Eriksson; Andrea,Manica

Whilst an African origin of modern humans is well established, the timings and routes of their expansions into Eurasia are the subject of heated debate, due to the scarcity of fossils and the lack of suitably old ancient DNA....

Animals Hominidae Humans Emigration And Immigration Genome Human Models Genetic Fossils History Ancient Africa Genetic Variation Biological Evolution Human Migration Dna Ancient

Published by: Nature Communications

Published on: Sep 25, 2021

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Nucleosome Plasticity Is a Critical Element of Chromatin Liquid-Liquid Phase Separation and Multivalent Nucleosome Interactions.

Stephen E,Farr; Esmae J,Woods; Jerelle A,Joseph; Adiran,Garaizar; Rosana,Collepardo-Guevara

Liquid-liquid phase separation (LLPS) is an important mechanism that helps explain the membraneless compartmentalization of the nucleus. Because chromatin compaction and LLPS are collective phenomena, linking their modulation to...

Chromatin Nucleosomes Histones Dna Nucleic Acid Conformation Algorithms Models Genetic Computer Simulation Molecular Dynamics Simulation

Published by: Nature Communications

Published on: Jun 18, 2021

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The Double-Stranded Dna-Binding Proteins Tebp-1 and Tebp-2 Form a Telomeric Complex with Pot-1.

Sabrina,Dietz; Miguel Vasconcelos,Almeida; Emily,Nischwitz; Jan,Schreier; Nikenza,Viceconte; Albert,Fradera-Sola; Christian,Renz; Alejandro,Ceron-Noriega; Helle D,Ulrich; Dennis,Kappei; René F,Ketting; Falk,Butter

Telomeres are bound by dedicated proteins, which protect them from DNA damage and regulate telomere length homeostasis. In the nematode Caenorhabditis elegans, a comprehensive understanding of the proteins interacting with the...

Germ Cells Telomere Animals Animals Genetically Modified Caenorhabditis Elegans Multiprotein Complexes Dna-Binding Proteins Telomere-Binding Proteins Caenorhabditis Elegans Proteins Protein Isoforms Dna Microscopy Fluorescence Phylogeny Binding Sites Base Sequence Protein Binding Mutation

Published by: Nature Communications

Published on: Jun 12, 2021

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Postal Recruitment for Genetic Studies of Preterm Birth a Feasibility Study.

Oonagh E,Keag; Lee,Murphy; Aoibheann,Bradley; Naomi,Deakin; Sonia,Whyte; Jane E,Norman; Sarah J,Stock

Background: Preterm birth (PTB) represents the leading cause of neonatal death. Large-scale genetic studies are necessary to determine genetic influences on PTB risk, but prospective cohort studies are expensive and...

Dna Phenotype Fetal Membranes Premature Birth Premature Premature Rupture Obstetric Labour Surveys And Questionnaires

Published by: Wellcome open research

Published on: May 24, 2020

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A Survey of Error Correction for Next Generation Sequencing

Ramgopal,Ahirwal; Prof. Anjana,Deen; Dr. Piyush Kumar,Shukla

Next-generation sequences (NGS) is a very important process drawback to review the population sizes of deoxyribonucleic acid molecules and to scale back the redundancies in NGS information. The arrival of next-generation...

Next-Generation Sequencing (Ngs) Error Correction Dna Rna

Published by: International Journal of Advanced Research in Computer Science

Published on: Jun 29, 2017

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James Darnell, Jr., 1973

The Rockefeller,University

James E. Darnell, Jr. The origins of mRNA and the structure of the mammalian chromosome Lecture delivered September 20, 1973 Posted with permission

Dna Rna Gene Expression

Published by: Academic Press

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Oswald Avery and the Sugar-Coated Microbe: [Dr. Oswald T. Avery]

Fulvio,Bardossi

Rockefeller University Research Profiles are a series of scientific profiles that were published quarterly, from 1980-1990, by the Rockefeller University. Each issue features the research and achievements of an individual...

Avery Oswald T Rockefeller University Scientists Pneumococcus Dna Virulent Pneumococci Cole Rufus Mccarty Maclyn Macleod Colin Life Sciences

Published by: The Rockefeller University

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The Rockefeller Institute Quarterly 1958, Vol.2, No.1

The Rockefeller,University

Charles I. Campbell, Editor

Avery Dna Zworykin Philip Bard Library Committee

Published by: The Rockefeller Institute

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The Efficacy of Dna Vaccination Is Enhanced in Mice by Targeting the Encoded Protein to Dendritic Cells

Godwin W.,Nchinda; Janelle,Kuroiwa; Margarita,Oks

DNA vaccines promote an immune response by providing antigen-encoding DNA to the recipient, but the efficacy of such vaccines needs improving. Many approaches have considerable potential but currently induce relatively weak...

Antigen Expression Cytokine Production Dendritic Cell Mucosal Immunity Vaccines Dna

Published by: Rockefeller University

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Science in a Byte

The Rockefeller,University

A new e-mail newsletter: In 1944, three Rockefeller University scientists discovered the chemical basis of heredity, laying the groundwork for the 1953 revelation DNA's double helix.

Oswald Avery Maclyn Mccarty Colin Macleod Dna Poster

Published by: The Rockefeller University

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Synthesis and Assembly of Oligonucleotide-Stabilized Lipid Micelles

Zenya,Yanoff; Jesse,Wun

Lipid micelles represent an important class of nanoparticle with the potential to enhance the solubility and delivery of hydrophobic drugs and imaging agents. Their small size (< 50 nm) makes them ideal candidates for both...

Micelles Nanoparticles Drug Delivery Oligonucleotide Dna Phosphoramidite Chemistry Biochemistry Biochemistry Biophysics And Structural Biology Life Sciences Molecular Biology

Published by: Ursinus College

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Search Magazine 1991, Vol.1, No.2

The Rockefeller,University

Jeffrey M Friedman Obesity Mary Baylies Campus Buildings Bruce Mcewen Dna Maclyn Mccarty Convocation Lewis Thomas

Published by: The Rockefeller University

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Effects of Dna Interactions on the Assembly and Stability of Oligonucleotide-Lipid Nanoparticles

Sophia,Roedema

Lipid micelles can be used to deliver hydrophobic pharmaceuticals in the bloodstream; however, micelles are inherently unstable because they require a large concentration of lipid to form, and they interact with serum proteins...

Nanoparticles Drug Delivery Dna Biochemistry Biochemistry Chemistry

Published by: Ursinus College

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News and Notes 1976, Vol.7, No.6

The Rockefeller,University

Annual Report Historical Photographs Dna John B Zabriskie Multiple Sclerosis Scientific Directors

Published by: The Rockefeller University

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News and Notes 1992, Vol.2, No.16

The Rockefeller,University

Floyd Ratliff Ru Authors Ru Gardends Kreek Lab Dna Neil Segil Library

Published by: The Rockefeller University

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65 Years Ago

The Rockefeller,University

65 years ago three scientists at The Rockefeller University Hospital discovered the chemical basis of heredity, launching the era of molecular biology

Oswald Avery Macklyn Mccarty Colin Macleod Dna Ru Hospital Campus Poster

Published by: The Rockefeller University

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Cationic Surfactant Mediated Hybridization and Hydrophobization of Dna Molecules at the Liquid/Liquid Interface and Their Phase Transfer

Murali,Sastry; Ashavani,Kumar; Mrunalini,Pattarkine; Vidya,Ramakrishnan; Krishna N.,Ganesh

Hybridization of complementary oligonucleotides mediated by a cationic surfactant at the water/hexane interface leads to hydrophobic, double-helical DNA which may be readily phase transferred to the organic phase and cast into...

Cationic Surfactant Hybridization Dna Water Hexane Interface Substrate Hydrophobic Oligonucleotides Analytical Diagnostic And Therapeutic Techniques And Equipment Biochemical And Biomolecular Engineering Biology And Biomimetic Materials Biomaterials Biomedical Biomedical Engineering And Bioengineering Bioresource And Agricultural Engineering Biotechnology Business Administration Management And Operations Computational Biology Food Biotechnology Food Microbiology Food Processing Health Economics Medical Biotechnology Medical Molecular Biology Medical Pharmacology Molecular Biology Molecular Cellular And Tissue Engineering Molecular Genetic And Biochemical Nutrition Molecular Genetics Nanomedicine Nanoscience And Nanotechnology Nanotechnology Nanotechnology Fabrication Pharmacy And Pharmaceutical Sciences

Published by: Harrisburg University of Science and Technology

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Search Magazine 1995, Winter

The Rockefeller,University

Oswald Avery Dna Vincent Fischetti Titia De Lange Fred Cross Stephen Burley Stephen Dinardo Jeffrey Friedman Tuberculosis Alexander Tomasz Ru Press Bruce Mcewen

Published by: The Rockefeller University

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Characterizing Lz6, a Suppressor of the Pam-1 Mutation in C. Elegans

AJ,Belville

The gene pam-1 encodes a puromycin-sensitive aminopeptidase that, in mutant form, causes several deleterious phenotypes in C. elegans, including lowered hatch rate and disturbed cytoskeletal and cortical activity around...

Genetics Gene Suppressor Caenorhabditis Elegans Protein Dna Biochemistry Biophysics And Structural Biology Life Sciences

Published by: Ursinus College

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News and Notes 1993, Vol.3, No.30

The Rockefeller,University

Gilla Kaplan Kunkel Lecture Ru Gardens Dna Kenji Adzuma Ru Hospital

Published by: The Rockefeller University