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The phenomenon of protein aggregation is associated with a wide range of human diseases. Our knowledge of the aggregation behaviour of viral proteins, however, is still rather limited. Here, we investigated this behaviour in the...

Animals Mammals Humans Proteome Amyloidogenic Proteins Severe Acute Respiratory Syndrome-Related Coronavirus

Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a potent chemotactic agent for monocytes, primarily produced by macrophages and endothelial cells. Significantly elevated levels of MCP-1/CCL2 were found in synovial fluids of...

Glycosylation Post-Translational Modifications Citrullination Peptidylarginine Deiminase Partial Degradation Endothelial Cells Animals Mammals Humans Arthritis Rheumatoid Citrulline Proteins

Among terrestrial vertebrates, only crown birds (Neornithes) rival mammals in terms of relative brain size and behavioural complexity. Relatedly, the anatomy of the avian central nervous system and associated sensory structures...

Ear Dinosaurs Brains Birds Labyrinth Endocranium Skull Base Brain Animals Mammals Phylogeny Fossils Ear Inner Biological Evolution

Mass extinctions have repeatedly shaped global biodiversity. The Cretaceous-Paleogene (K-Pg) mass extinction caused the demise of numerous vertebrate groups, and its aftermath saw the rapid diversification of surviving mammals...

Animals Birds Fishes Mammals Snakes Biodiversity Phylogeny Fossils History Ancient Genetic Speciation Extinction Biological Amphibians Phylogeography Animal Distribution Dna Ancient

Animals Mammals Mice Luciferases Luciferases Renilla Protein Engineering Enzyme Stability Temperature Mutagenesis Binding Sites Protein Conformation Kinetics Mutation Catalysis Molecular Dynamics Simulation