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Placental adaptations supporting fetal growth during normal and adverse gestational environments.
NEW FINDINGS: What is the topic of this review? How the placenta, which transports nutrients and oxygen to the fetus, may alter its support of fetal growth developmentally and with adverse gestational conditions. What advances...
Elucidation of the mechanisms of action of Bacteriophage K / nano-emulsion formulations against <i>S. aureus</i> via measurement of particle size and zeta potential
In earlier work we have demonstrated the effect that nano-emulsions have on bacterial growth, and most importantly the enhanced bacteriophage infectivity against S. aureus in planktonic culture when phage are carried in...
Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis
Martin H Fabry, Federica A Falconio, Fadwa Joud, Emily K Lythgoe, Benjamin Czech, Gregory J Hannon
Aug 11, 2021
The PIWI-interacting RNA (piRNA) pathway controls transposon expression in animal germ cells, thereby ensuring genome stability over generations. In Drosophila, piRNAs are intergenerationally inherited through the maternal...
Elucidation of the mechanisms of action of Bacteriophage K / nano-emulsion formulations against <i>S. aureus</i> via measurement of particle size and zeta potential
In earlier work we have demonstrated the effect that nano-emulsions have on bacterial growth, and most importantly the enhanced bacteriophage infectivity against S. aureus in planktonic culture when phage are carried in...
Molecular Optomechanics Approach to Surface-Enhanced Raman Scattering.
ConspectusMolecular vibrations constitute one of the smallest mechanical oscillators available for micro-/nanoengineering. The energy and strength of molecular oscillations depend delicately on the attached specific functional...
Hollow-fiber membrane technology
Dermal bioavailability is currently estimated through skin penetration studies using ex vivo models, which lack any measure of capillary bed function, and thus do not fully reproduce physiological conditions. We propose a novel...
Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells.
BACKGROUND: 209 000 new cases of renal carcinoma are diagnosed each year worldwide and new therapeutic targets are urgently required. The great majority of clear cell renal cancer involves inactivation of VHL, which acts as a...
The Serine Protease Homolog, Scarface, Is Sensitive to Nutrient Availability and Modulates the Development of the <i>Drosophila</i> Blood-Brain Barrier.
The adaptable transcriptional response to changes in food availability not only ensures animal survival but also lets embryonic development progress. Interestingly, the CNS is preferentially protected from periods of...
Obesity and gestational diabetes independently and collectively induce specific effects on placental structure, inflammation and endocrine function in a cohort of South African women.
Ezekiel Musa, Esteban Salazar-Petres, Afolake Arowolo, Naomi Levitt, Mushi Matjila, Amanda N Sferruzzi-Perri
Feb 27, 2023
Maternal obesity and gestational diabetes mellitus (GDM) are associated with insulin resistance and health risks for mother and offspring. Obesity is also characterized by low-grade inflammation, which in turn, impacts insulin...
Maternal and Fetal PI3K-p110α Deficiency Induces Sex-Specific Changes in Conceptus Growth and Placental Mitochondrial Bioenergetic Reserve in Mice.
Daniela Pereira-Carvalho, Esteban Salazar-Petres, Jorge Lopez-Tello, Amanda N Sferruzzi-Perri
Oct 24, 2022
Fetal growth is reliant on placental formation and function, which, in turn, requires the energy produced by the mitochondria. Prior work has shown that both mother and fetus operate via the phosphoinositol 3-kinase (PI3K)-p110α...
Predicting COVID-19 progression from diagnosis to recovery or death linking primary care and hospital records in Castilla y León (Spain)
This paper analyses COVID-19 patients’ dynamics during the first wave in the region of Castilla y León (Spain) with around 2.4 million inhabitants using multi-state competing risk survival models. From the date registered as the...
Imaging Brain Glx Dynamics in Response to Pressure Pain Stimulation
Luke A. Jelen, David J. Lythgoe, Jade B. Jackson, Matthew A. Howard, James M. Stone, Alice Egerton
Aug 11, 2021
Glutamate signalling is increasingly implicated across a range of psychiatric, neurological and pain disorders. Reliable methodologies are needed to probe the glutamate system and understand glutamate dynamics in vivo....
Imaging Brain Glx Dynamics in Response to Pressure Pain Stimulation
Luke A Jelen, David J Lythgoe, Jade B Jackson, Matthew A Howard, James M Stone, Alice Egerton
Aug 27, 2021
Glutamate signalling is increasingly implicated across a range of psychiatric, neurological and pain disorders. Reliable methodologies are needed to probe the glutamate system and understand glutamate dynamics in vivo....
Mixing closures for conservation laws in stratified flows
A closure for shocks involving the mixing of the fluids in two-layer stratified flows is proposed. The closure maximizes the rate of mixing, treating the dynamical hydraulic equations and entropy conditions as constraints. This...
Maternal and Intrauterine Influences on Feto-Placental Growth Are Accompanied by Sexually Dimorphic Changes in Placental Mitochondrial Respiration, and Metabolic Signalling Pathways
Esteban Salazar-Petres, Daniela Pereira-Carvalho, Jorge Lopez-Tello, Amanda N. Sferruzzi-Perri
Apr 05, 2023
Published by: MDPI
Pregnancy-induced changes in β-cell function
Maternal metabolic adaptations during pregnancy ensure appropriate nutrient supply to the developing fetus. This is facilitated by reductions in maternal peripheral insulin sensitivity, which enables glucose to be available in...
Predicting COVID-19 progression from diagnosis to recovery or death linking primary care and hospital records in Castilla y León (Spain).
This paper analyses COVID-19 patients' dynamics during the first wave in the region of Castilla y León (Spain) with around 2.4 million inhabitants using multi-state competing risk survival models. From the date registered as the...
Adolescent Adult Aged Aged 80 and over covid-19 Calibration Child Child Preschool Comorbidity Confidence Intervals Disease Progression Female Hospital Records Hospitals Humans Infant Infant Newborn Male Middle Aged Primary Health Care Probability Proportional Hazards Models Reproducibility of Results Spain Young Adult COVID-19 Drug Treatment
The diurnal cycle and the meridional extent of the tropics
An explanation is proposed for the meridional extent of the Hadley cells: the diurnal waves forced by solar heating trapped between −30°and 30°. These baroclinic waves, we propose, give rise to the daily nature of tropical...
Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe.
BACKGROUND: Neural stem cells generate all of the neurons and glial cells in the central nervous system, both during development and in the adult to maintain homeostasis. In the Drosophila optic lobe, neuroepithelial cells...
neural stem cell Neuralized Notch Optic Lobe Animals Animals Genetically Modified Drosophila Drosophila Proteins Gene Expression Regulation Developmental Intracellular Signaling Peptides and Proteins Membrane Proteins Neural Stem Cells Neuroepithelial Cells Neurogenesis Neurons Optic Lobe Nonmammalian Receptors Notch Signal Transduction
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