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Identifying Factors of Indian Health System and Their Influence for Providing Good Customer Care
Customer relationship management is important for any service industry as a satisfied customer is likely to remain loyal, spread publicity thereby ensuring profits to the organizations. Healthcare is an important and...
Published by: IGI Global Scientific Publishing
A Block-Based Arithmetic Entropy Encoding Scheme for Medical Images
The digitization of human body, especially for treatment of diseases can generate a large volume of data. This generated medical data has a large resolution and bit depth. In the field of medical diagnosis, lossless compression...
Published by: IGI Global Scientific Publishing
A Block-Based Arithmetic Entropy Encoding Scheme for Medical Images
The digitization of human body, especially for treatment of diseases can generate a large volume of data. This generated medical data has a large resolution and bit depth. In the field of medical diagnosis, lossless compression...
Medicine and Healthcare Medical Diagnosis and Practice Medical Imaging Computer Science and Information Technology Media and Communications
Published by: IGI Global Scientific Publishing
A network analysis of adolescent mental well-being during the coronavirus pandemic
Meenakshi Shukla, Alison F.W. Wu, Iris Lavi, Laura Riddleston, Taryn Hutchinson, Jennifer Y.F. Lau
Feb 28, 2022
The COVID-19 pandemic continues to pose unprecedented threat globally. Adolescents and youth may be especially susceptible to the long-term impact of these stressors, thus intervening early is an important priority. However...
A network analysis of adolescent mental well-being during the coronavirus pandemic
Meenakshi Shukla, Alison F.W. Wu, Iris Lavi, Laura Riddleston, Taryn Hutchinson, Jennifer Y.F. Lau
Feb 28, 2022
The COVID-19 pandemic continues to pose unprecedented threat globally. Adolescents and youth may be especially susceptible to the long-term impact of these stressors, thus intervening early is an important priority. However...
Ultrafast melting and recovery of collective order in the excitonic insulator Ta 2 NiSe 5
Hope M. Bretscher, Paolo Andrich, Prachi Telang, Anupam Singh, Luminita Harnagea, A. K. Sood, Akshay Rao
Mar 16, 2021
Abstract: The layered chalcogenide Ta2NiSe5 has been proposed to host an excitonic condensate in its ground state, a phase that could offer a unique platform to study and manipulate many-body states at room temperature. However...
Does prospective mental imagery predict symptoms of negative affect and anhedonia in young people?
Taryn Hutchinson, Laura Riddleston, Iris Lavi, Victoria Pile, Alan Meehan, Meenakshi Shukla, Jennifer Y. F. Lau
May 05, 2024
Adolescent depression is associated with unhelpful emotional mental imagery. Here, we investigated whether vividness of negative and positive prospective mental imagery predict negative affect and anhedonia in adolescents. 111...
Does prospective mental imagery predict symptoms of negative affect and anhedonia in young people?
Taryn Hutchinson, Laura Riddleston, Iris Lavi, Victoria Pile, Alan Meehan, Meenakshi Shukla, Jennifer Y. F. Lau
May 05, 2024
Adolescent depression is associated with unhelpful emotional mental imagery. Here, we investigated whether vividness of negative and positive prospective mental imagery predict negative affect and anhedonia in adolescents. 111...
Online Synchronous Teaching During a Pandemic
As the novel Coronavirus (COVID-19) spread rapidly across the globe, most educational institutions tried to address major challenges of engaging students in a productive way and disseminating knowledge through online learning....
Published by: IGI Global Scientific Publishing
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.
Single cell RNA-seq analysis reveals temporally-regulated and quiescence-regulated gene expression in Drosophila larval neuroblasts.
Noah Dillon, Ben Cocanougher, Chhavi Sood, Xin Yuan, Andrea B Kohn, Leonid L Moroz, Sarah E Siegrist, Marta Zlatic, Chris Q Doe
Sep 24, 2022
Insulin Signaling Intermediate neural progenitor Neuroblast quiescence Single cell RNA-sequencing Temporal transcription factor Animals Cell Lineage Drosophila Drosophila Proteins Drosophila melanogaster Gene Expression Gene Expression Regulation Developmental Larva Neural Stem Cells Sequence Analysis RNA
Single cell RNA-seq analysis reveals temporally-regulated and quiescence-regulated gene expression in Drosophila larval neuroblasts.
Noah Dillon, Ben Cocanougher, Chhavi Sood, Xin Yuan, Andrea B Kohn, Leonid L Moroz, Sarah E Siegrist, Marta Zlatic, Chris Q Doe
Aug 24, 2022
The mechanisms that generate neural diversity during development remains largely unknown. Here, we use scRNA-seq methodology to discover new features of the Drosophila larval CNS across several key developmental timepoints. We...
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.
Emilie Abby, Stefan C Dentro, Michael WJ Hall, Joanna C Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W Siebel, Moritz Gerstung, Benjamin A Hall, Philip H Jones
Feb 19, 2023
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this...
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.
Bartomeu Colom, Maria P Alcolea, Gabriel Piedrafita, Michael WJ Hall, Agnieszka Wabik, Stefan C Dentro, Joanna C Fowler, Albert Herms, Charlotte King, Swee Hoe Ong, Roshan K Sood, Moritz Gerstung, Inigo Martincorena, Benjamin A Hall, Philip H Jones
Apr 28, 2020
ADAM10 Protein Amyloid Precursor Protein Secretases Animals Cell Lineage Diethylnitrosamine Epithelium esophagus Female High-Throughput Nucleotide Sequencing Male Membrane Proteins Mice Inbred C57BL Mice Transgenic Mutation Receptor Notch1 Receptor Notch2 Reproducibility of Results Tumor Suppressor Protein p53
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.
Kasumi Murai, Stefan Dentro, Swee Hoe Ong, Roshan Sood, David Fernandez-Antoran, Albert Herms, Vasiliki Kostiou, Irina Abnizova, Benjamin A Hall, Moritz Gerstung, Philip H Jones
Nov 20, 2022
Aging normal human oesophagus accumulates TP53 mutant clones. These are the origin of most oesophageal squamous carcinomas, in which biallelic TP53 disruption is almost universal. However, how p53 mutant clones expand and...
Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).
Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling.
Jayaprakash Periasamy, Vadiraj Kurdekar, Subbarao Jasti, Mamatha B Nijaguna, Sanjana Boggaram, Manjunath A Hurakadli, Dhruv Raina, Lokavya Meenakshi Kurup, Chetan Chintha, Kavyashree Manjunath, Aneesh Goyal, Gayathri Sadasivam, Kavitha Bharatham, Muralidhara Padigaru, Vijay Potluri, Ashok R Venkitaraman
Aug 23, 2018
Intracellular signals triggered by DNA breakage flow through proteins containing BRCT (BRCA1 C-terminal) domains. This family, comprising 23 conserved phosphopeptide-binding modules in man, is inaccessible to small-molecule...
BRCA1 BRCT domain DNA damage response drug-like inhibitor lead discovery Structure-Activity Relationship BRCA1 Protein Cell Survival Cells Cultured Fluorescence Resonance Energy Transfer HEK293 Cells Humans Molecular Dynamics Simulation Molecular Structure Phosphopeptides Protein Domains Signal Transduction Structure-Activity Relationship
Imaging the coherent propagation of collective modes in the excitonic insulator Ta<sub>2</sub>NiSe<sub>5</sub> at room temperature.
Hope M Bretscher, Paolo Andrich, Yuta Murakami, Denis Golež, Benjamin Remez, Prachi Telang, Anupam Singh, Luminita Harnagea, Nigel R Cooper, Andrew J Millis, Philipp Werner, A K Sood, Akshay Rao
Aug 11, 2021
Excitonic insulators host a condensate of electron-hole pairs at equilibrium, giving rise to collective many-body effects. Although several materials have emerged as excitonic insulator candidates, evidence of long-range...
Published by: Science advances
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.
Emilie Abby, Stefan C Dentro, Michael WJ Hall, Joanna C Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W Siebel, Moritz Gerstung, Benjamin A Hall, Philip H Jones
Feb 16, 2023
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this...
The Macronuclear Genome of $\textit{Stentor coeruleus}$ Reveals Tiny Introns in a Giant Cell
MM Slabodnick, JG Ruby, SB Reiff, EC Swart, S Gosai, S Prabakaran, E Witkowska, GE Larue, S Fisher, RM Freeman, J Gunawardena, W Chu, NA Stover, BD Gregory, M Nowacki, J Derisi, SW Roy, WF Marshall, P Sood
Apr 12, 2017
Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.
Tom J Phillips, Hannah Scott, David A Menassa, Ashleigh L Bignell, Aman Sood, Jude S Morton, Takami Akagi, Koki Azuma, Mark F Rogers, Catherine E Gilmore, Gareth J Inman, Simon Grant, Yealin Chung, Mais M Aljunaidy, Christy-Lynn Cooke, Bruno R Steinkraus, Andrew Pocklington, Angela Logan, Gavin P Collett, Helena Kemp, Peter A Holmans, Michael P Murphy, Tudor A Fulga, Andrew M Coney, Mitsuru Akashi, Sandra T Davidge, C Patrick Case
Jun 18, 2018
Some neuropsychiatric disease, including schizophrenia, may originate during prenatal development, following periods of gestational hypoxia and placental oxidative stress. Here we investigated if gestational hypoxia promotes...
Selection of oncogenic mutant clones in normal human skin varies with body site.
Joanna C Fowler, Charlotte King, Christopher Bryant, Michael Hall, Roshan Sood, Swee Hoe Ong, Eleanor Earp, David Fernandez-Antoran, Jonas Koeppel, Stefan C Dentro, David Shorthouse, Amer Durrani, Kate Fife, Edward Rytina, Doreen Milne, Amit Roshan, Krishnaa Mahububani, Kourosh Saeb-Parsy, Benjamin A Hall, Moritz Gerstung, Philip H Jones
Oct 23, 2020
Skin cancer risk varies substantially across the body, yet how this relates to the mutations found in normal skin is unknown. Here we mapped mutant clones in skin from high and low risk sites. The density of mutations varied by...
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion.
Petra Mlcochova, Steven A Kemp, Mahesh Shanker Dhar, Guido Papa, Bo Meng, Isabella ATM Ferreira, Rawlings Datir, Dami A Collier, Anna Albecka, Sujeet Singh, Rajesh Pandey, Jonathan Brown, Jie Zhou, Niluka Goonawardane, Swapnil Mishra, Charles Whittaker, Thomas Mellan, Robin Marwal, Meena Datta, Shantanu Sengupta, Kalaiarasan Ponnusamy, Venkatraman Srinivasan Radhakrishnan, Adam Abdullahi, Oscar Charles, Partha Chattopadhyay, Priti Devi, Daniela Caputo, Tom Peacock, Chand Wattal, Neeraj Goel, Ambrish Satwik, Raju Vaishya, Meenakshi Agarwal, Indian SARS-CoV-2 Genomics Consortium (INSACOG), Genotype to Phenotype Japan (G2P-Japan) Consortium, CITIID-NIHR BioResource COVID-19 Collaboration, Antranik Mavousian, Joo Hyeon Lee, Jessica Bassi, Chiara Silacci-Fegni, Christian Saliba, Dora Pinto, Takashi Irie, Isao Yoshida, William L Hamilton, Kei Sato, Samir Bhatt, Seth Flaxman, Leo C James, Davide Corti, Luca Piccoli, Wendy S Barclay, Partha Rakshit, Anurag Agrawal, Ravindra K Gupta
Sep 10, 2021
The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages...
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion
Petra Mlcochova, Steven A. Kemp, Mahesh Shanker Dhar, Guido Papa, Bo Meng, Isabella A. T. M. Ferreira, Rawlings Datir, Dami A. Collier, Anna Albecka, Sujeet Singh, Rajesh Pandey, Jonathan Brown, Jie Zhou, Niluka Goonawardane, Swapnil Mishra, Charles Whittaker, Thomas Mellan, Robin Marwal, Meena Datta, Shantanu Sengupta, Kalaiarasan Ponnusamy, Venkatraman Srinivasan Radhakrishnan, Adam Abdullahi, Oscar Charles, Partha Chattopadhyay, Priti Devi, Daniela Caputo, Tom Peacock, Chand Wattal, Neeraj Goel, Ambrish Satwik, Raju Vaishya, Meenakshi Agarwal, Antranik Mavousian, Joo Hyeon Lee, Jessica Bassi, Chiara Silacci-Fegni, Christian Saliba, Dora Pinto, Takashi Irie, Isao Yoshida, William L. Hamilton, Kei Sato, Samir Bhatt, Seth Flaxman, Leo C. James, Davide Corti, Luca Piccoli, Wendy S. Barclay, Partha Rakshit, Anurag Agrawal, Ravindra K. Gupta, Himanshu Chauhan, Tanzin Dikid, Hema Gogia, Hemlata Lall, Kaptan Verma, Manoj K. Singh, Namita Soni, Namonarayan Meena, Preeti Madan, Priyanka Singh, Ramesh Sharma, Rajeev Sharma, Sandhya Kabra, Sattender Kumar, Swati Kumari, Uma Sharma, Urmila Chaudhary, Sridhar Sivasubbu, Vinod Scaria, J. K. Oberoi, Reena Raveendran, S. Datta, Saumitra Das, Arindam Maitra, Sreedhar Chinnaswamy, Nidhan Kumar Biswas, Ajay Parida, Sunil K. Raghav, Punit Prasad, Apurva Sarin, Satyajit Mayor, Uma Ramakrishnan, Dasaradhi Palakodeti, Aswin Sai Narain Seshasayee, K. Thangaraj, Murali Dharan Bashyam, Ashwin Dalal, Manoj Bhat, Yogesh Shouche, Ajay Pillai, Priya Abraham, Varsha Atul Potdar, Sarah S. Cherian, Anita Sudhir Desai, Chitra Pattabiraman, M. V. Manjunatha, Reeta S. Mani, Gautam Arunachal Udupi, Vinay Nandicoori, Karthik Bharadwaj Tallapaka, Divya Tej Sowpati, Ryoko Kawabata, Nanami Morizako, Kenji Sadamasu, Hiroyuki Asakura, Mami Nagashima, Kazuhisa Yoshimura, Jumpei Ito, Izumi Kimura, Keiya Uriu, Yusuke Kosugi, Mai Suganami, Akiko Oide, Miyabishara Yokoyama, Mika Chiba, Akatsuki Saito, Erika P. Butlertanaka, Yuri L. Tanaka, Terumasa Ikeda, Chihiro Motozono, Hesham Nasser, Ryo Shimizu, Yue Yuan, Kazuko Kitazato, Haruyo Hasebe, So Nakagawa, Jiaqi Wu, Miyoko Takahashi, Takasuke Fukuhara, Kenta Shimizu, Kana Tsushima, Haruko Kubo, Kotaro Shirakawa, Yasuhiro Kazuma, Ryosuke Nomura, Yoshihito Horisawa, Akifumi Takaori-Kondo, Kenzo Tokunaga, Seiya Ozono, Stephen Baker, Gordon Dougan, Christoph Hess, Nathalie Kingston, Paul J. Lehner, Paul A. Lyons, Nicholas J. Matheson, Willem H. Owehand, Caroline Saunders, Charlotte Summers, James E. D. Thaventhiran, Mark Toshner, Michael P. Weekes, Patrick Maxwell, Ashley Shaw, Ashlea Bucke, Jo Calder, Laura Canna, Jason Domingo, Anne Elmer, Stewart Fuller, Julie Harris, Sarah Hewitt, Jane Kennet, Sherly Jose, Jenny Kourampa, Anne Meadows, Criona O’Brien, Jane Price, Cherry Publico, Rebecca Rastall, Carla Ribeiro, Jane Rowlands, Valentina Ruffolo, Hugo Tordesillas, Ben Bullman, Benjamin J. Dunmore, Stuart Fawke, Stefan Gräf, Josh Hodgson, Christopher Huang, Kelvin Hunter, Emma Jones, Ekaterina Legchenko, Cecilia Matara, Jennifer Martin, Federica Mescia, Ciara O’Donnell, Linda Pointon, Nicole Pond, Joy Shih, Rachel Sutcliffe, Tobias Tilly, Carmen Treacy, Zhen Tong, Jennifer Wood, Marta Wylot, Laura Bergamaschi, Ariana Betancourt, Georgie Bower, Chiara Cossetti, Aloka De Sa, Madeline Epping, Nick Gleadall, Richard Grenfell, Andrew Hinch, Oisin Huhn, Sarah Jackson, Isobel Jarvis, Ben Krishna, Daniel Lewis, Joe Marsden, Francesca Nice, Georgina Okecha, Ommar Omarjee, Marianne Perera, Martin Potts, Nathan Richoz, Veronika Romashova, Natalia Savinykh Yarkoni, Rahul Sharma, Luca Stefanucci, Jonathan Stephens, Mateusz Strezlecki, Lori Turner, Eckart M. D. D. De Bie, Katherine Bunclark, Masa Josipovic, Michael Mackay, Sabrina Rossi, Mayurun Selvan, Sarah Spencer, Cissy Yong, John Allison, Helen Butcher, Debbie Clapham-Riley, Eleanor Dewhurst, Anita Furlong, Barbara Graves, Jennifer Gray, Tasmin Ivers, Mary Kasanicki, Emma Le Gresley, Rachel Linger, Sarah Meloy, Francesca Muldoon, Nigel Ovington, Sofia Papadia, Isabel Phelan, Hannah Stark, Kathleen E. Stirrups, Paul Townsend, Neil Walker, Jennifer Webster, Ingrid Scholtes, Sabine Hein, Rebecca King
Nov 03, 2021
Abstract: The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing...
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