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Results: 201
A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres.
Elisa Mentegari, Federica Bertoletti, Miroslava Kissova, Elisa Zucca, Silvia Galli, Giulia Tagliavini, Anna Garbelli, Antonio Maffia, Silvia Bione, Elena Ferrari, Fabrizio d'Adda di Fagagna, Sofia Francia, Simone Sabbioneda, Liuh-Yow Chen, Joachim Lingner, Valerie Bergoglio, Jean-Sébastien Hoffmann, Ulrich Hübscher, Emmanuele Crespan, Giovanni Maga
Feb 28, 2021
Telomerase negative cancer cell types use the Alternative Lengthening of Telomeres (ALT) pathway to elongate telomeres ends. Here, we show that silencing human DNA polymerase (Pol λ) in ALT cells represses ALT activity and...
DNA double-strand breaks (DSBs) extra-chromosomal telomeric repeats (ECTRs) promyelocytic leukemia (PML) bodies alternative lengthening of telomeres (ALT) DNA polymerase λ microhomology-mediated strand transfer (MMST) activity telomere dysfunction-induced foci (TIFs) telomere stress Aminopeptidases Cell Line Tumor DNA Polymerase beta G-Quadruplexes Humans Multiprotein Complexes Replication Protein A Serine Proteases Shelterin Complex Telomere Telomere Homeostasis Telomere-Binding Proteins
Antioxidant Therapy in Parkinson's Disease
Reactive oxygen species (ROS) play an important role as endogenous mediators in several cellular signalling pathways. However, at high concentrations they can also exert deleterious effects by reacting with many macromolecules...
Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome
Individuals with 22q11.2 microdeletion syndrome (22q11.2 DS) show cognitive and behavioral dysfunctions, developmental delays in childhood and risk of developing schizophrenia and autism. Despite extensive previous studies in...
DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster.
Federica De Lazzari, Francesco Agostini, Davide Doni, Sandro Malacrida, Mauro A Zordan, Paola Costantini, Luigi Bubacco, Federica Sandrelli, Marco Bisaglia
Aug 06, 2022
Redox homeostasis is a vital process the maintenance of which is assured by the presence of numerous antioxidant small molecules and enzymes and the alteration of which is involved in many pathologies, including several...
Necessity 20 Years On
Investment tribunals have fleshed out the requirements of the defence of necessity in Article 25 of the Articles on State Responsibility. This article considers the impact of necessity in international investment law and in...
DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster.
Federica De Lazzari, Francesco Agostini, Davide Doni, Sandro Malacrida, Mauro A Zordan, Paola Costantini, Luigi Bubacco, Federica Sandrelli, Marco Bisaglia
Sep 25, 2022
Redox homeostasis is a vital process the maintenance of which is assured by the presence of numerous antioxidant small molecules and enzymes and the alteration of which is involved in many pathologies, including several...
Habitat mapping of the Maltese continental shelf using acoustic textures and bathymetric analyses
The uneven mapping of the Maltese continental shelf precludes a full assessment of its marine habitats, important for their monitoring and conservation in line with the EU Marine Strategy Framework Directive and local...
Selectivity-permeability optimization of functionalised CNT-polymer membranes for water treatment
Polymer membranes incorporating carbon nanotubes (CNT) belong to two broad categories: Vertically aligned (VA-CNT) membranes, where the polymer acts solely as a matrix embedding an aligned forest of nanotubes, and thin film...
Selectivity-permeability optimization of functionalised CNT-polymer membranes for water treatment
Polymer membranes incorporating carbon nanotubes (CNT) belong to two broad categories: Vertically aligned (VA-CNT) membranes, where the polymer acts solely as a matrix embedding an aligned forest of nanotubes, and thin film...
Was Brexit triggered by the old and unhappy? Or by financial feelings?
On 23 June 2016, the United Kingdom voted in favour of ‘Brexit’. This paper is an attempt to understand why. It examines the micro-econometric predictors of anti-EU sentiment. The paper provides the first evidence for the idea...
Relations between theory of mind and executive function in middle childhood
Studies with preschool children have shown significant links between children's executive function (EF) and theory of mind (ToM), but few studies have examined these associations in primary school children. To address this gap...
Improving prediction of disease outcome for inflammatory bowel disease
Introduction: Inflammatory bowel diseases (IBDs) are lifelong conditions causing relapsing inflammation of the intestine. In the absence of a cure, clinical management of IBDs is extremely challenging since they present with a...
Thermodynamics of high-pressure ice phases explored with atomistic simulations
Aleks Reinhardt, Mandy Bethkenhagen, Federica Coppari, Marius Millot, Sebastien Hamel, Bingqing Cheng
Sep 10, 2022
Most experimentally known high-pressure ice phases have a body-centred cubic (bcc) oxygen lattice. Our large-scale molecular-dynamics simulations with a machine-learning potential indicate that, amongst these bcc ice phases...
Habitat mapping of the Maltese continental shelf using acoustic textures and bathymetric analyses
The uneven mapping of the Maltese continental shelf precludes a full assessment of its marine habitats, important for their monitoring and conservation in line with the EU Marine Strategy Framework Directive and local...
Lack of effect of apolipoprotein C3 polymorphisms on indices of liver steatosis, lipid profile and insulin resistance in obese Southern Europeans.
The Camels of Charles the Bald
SG Ottewill-Soulsby
Feb 24, 2017
This article investigates a previously neglected aspect of diplomatic relations between the Carolingians and the Umayyads of al-Andalus, the camels sent by Emir Muḥammad I to Charles the Bald, King of the West Franks, in 865. In...
Was Brexit triggered by the old and unhappy? Or by financial feelings?
On 23 June 2016, the United Kingdom voted in favour of ‘Brexit’. This paper is an attempt to understand why. It examines the micro-econometric predictors of anti-EU sentiment. The paper provides the first evidence for the idea...
Mapping the expression of transient receptor potential channels across murine placental development.
Katrien De Clercq, Vicente Pérez-García, Rieta Van Bree, Federica Pollastro, Karen Peeraer, Thomas Voets, Joris Vriens
Jul 07, 2021
placental development Primary trophoblast cells TRP channels trophoblast stem cells Animals Calcium Channels Calcium Signaling Cell Differentiation Cell Proliferation Female Gene Expression Regulation Mice Mice Inbred C57BL Mouse embryonic stem cells Placenta Placentation Pregnancy Stem Cells TRPV Cation Channels Transient Receptor Potential Channels Trophoblasts
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