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Metal-Bound Methisazone; Novel Drugs Targeting Prophylaxis and Treatment of SARS-CoV-2, a Molecular Docking Study.
Ahmed Abdelaal Ahmed Mahmoud M Alkhatip, Michail Georgakis, Lucio R Montero Valenzuela, Mohamed Hamza, Ehab Farag, Jaqui Hodgkinson, Hisham Hosny, Ahmed M Kamal, Mohamed Wagih, Amr Naguib, Hany Yassin, Haytham Algameel, Mohamed Elayashy, Mohamed Abdelhaq, Mohamed I Younis, Hassan Mohamed, Mohammed Abdulshafi, Mohamed A Elramely
Mar 16, 2021
SARS-CoV-2 currently lacks effective first-line drug treatment. We present promising data from in silico docking studies of new Methisazone compounds (modified with calcium, Ca; iron, Fe; magnesium, Mg; manganese, Mn; or zinc...
covid-19 SARS-CoV-2 Molecular docking prophylaxis Treatment Antiviral Agents Calcium Coronavirus 3C Proteases Coronavirus Papain-Like Proteases Coronavirus RNA-Dependent RNA Polymerase Drug Design Humans Iron Magnesium manganese Metals Methisazone Models Molecular Molecular Docking Simulation Molecular Dynamics Simulation Protein Binding SARS-CoV-2 Spike Glycoprotein Coronavirus Zinc COVID-19 Drug Treatment
Is temporary employment a cause or consequence of poor mental health? A panel data analysis
Mental health status has an association with labour market outcomes. If people in temporary employment have poorer mental health than those in permanent employment then it is consistent with two mutually inclusive possibilities...
“Choose to be optimistic, it feels better?” Evidence of optimism on employment utility
Individual’s expected wages exceed predicted market wages. Rational expectations imply the divergence should be zero. If individuals over-estimate the return from their attributes and view the paid-employment return distribution...
Modifiable Lifestyle Factors and Risk of Stroke
Mendelian Randomization Analysis Body Mass Index Educational Status Genetics Risk Factors Smoking stroke Body Mass Index Brain Ischemia Educational Status Genetic Predisposition to Disease Genome-Wide Association Study Health Promotion Humans Life Style Mendelian Randomization Analysis Polymorphism Single Nucleotide risk Risk Factors Smoking stroke
Temporary employment, job satisfaction and subjective well-being
This article is concerned with whether employees on temporary contracts in Britain report lower well-being than those on permanent contracts, and whether this relationship is mediated by differences in dimensions of job...
Absence management of migrant agency workers in the food manufacturing sector
Temporary workers in low-skilled roles often experience ‘hard’ HRM practices, for example the use of the Bradford Factor to monitor absence, rather than using incentives to reward attendance. However, this peripheral workforce...
Is temporary employment a cause or consequence of poor mental health? A panel data analysis
Mental health status has an association with labour market outcomes. If people in temporary employment have poorer mental health than those in permanent employment then it is consistent with two mutually inclusive possibilities...
“Choose to be optimistic, it feels better?” Evidence of optimism on employment utility
Individual’s expected wages exceed predicted market wages. Rational expectations imply the divergence should be zero. If individuals over-estimate the return from their attributes and view the paid-employment return distribution...
Absence management of migrant agency workers in the food manufacturing sector
Temporary workers in low-skilled roles often experience ‘hard’ HRM practices, for example the use of the Bradford Factor to monitor absence, rather than using incentives to reward attendance. However, this peripheral workforce...
Dose-response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus.
Stephen Burgess, Rainer Malik, Bowen Liu, Amy M Mason, Marios K Georgakis, Martin Dichgans, Dipender Gill
Nov 20, 2020
AIMS/HYPOTHESIS: Our aim was to investigate the relationship between average blood glucose levels and incident CHD in individuals without diabetes mellitus. METHODS: To investigate average blood glucose levels, we studied HbA1c...
Average blood glucose levels CHD Mendelian randomisation Adult Aged Biomarkers Blood Glucose Coronary Disease Female Genetic Predisposition to Disease Glycated Hemoglobin Humans Incidence Male Mendelian Randomization Analysis Middle Aged Phenotype Polymorphism Single Nucleotide Time Factors United Kingdom
Risk and structural instability in US house prices
This paper employs a Component GARCH in Mean model to show that house prices across a number of major US cities between 1987 and 2009 have displayed asset market properties in terms of both risk-return relationships and...
Understanding the perception of the “Migrant Work Ethic”
Over the last decade, the UK has experienced unprecedented increases in migration associated with the 2004 A8 expansion of the European Union. These migrant workers have been praised by managers in the UK, who have frequently...
Risk and structural instability in US house prices
This paper employs a Component GARCH in Mean model to show that house prices across a number of major US cities between 1987 and 2009 have displayed asset market properties in terms of both risk-return relationships and...
Understanding the perception of the “Migrant Work Ethic”
Over the last decade, the UK has experienced unprecedented increases in migration associated with the 2004 A8 expansion of the European Union. These migrant workers have been praised by managers in the UK, who have frequently...
Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups.
Marios K Georgakis, Rainer Malik, Tom G Richardson, Joanna MM Howson, Christopher D Anderson, Stephen Burgess, G Kees Hovingh, Martin Dichgans, Dipender Gill
Aug 11, 2022
BACKGROUND: Interleukin 6 (IL-6) signaling is being investigated as a therapeutic target for atherosclerotic cardiovascular disease (CVD). While changes in circulating high-sensitivity C-reactive protein (hsCRP) are used as a...
Temporary employment, job satisfaction and subjective well-being
This article is concerned with whether employees on temporary contracts in Britain report lower well-being than those on permanent contracts, and whether this relationship is mediated by differences in dimensions of job...
Stick or Spill? Scaling Relationships for the Binding Energies of Adsorbates on Single-Atom Alloy Catalysts.
Single-atom alloy catalysts combine catalytically active metal atoms, present as dopants, with the selectivity of coinage metal hosts. Determining whether adsorbates stick at the dopant or spill over onto the host is key to...
Published by: The journal of physical chemistry letters
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease
Marios K Georgakis, Eric L Harshfield, Rainer Malik, Nora Franceschini, Claudia Langenberg, Nicholas J Wareham, Hugh S Markus, Martin Dichgans
Oct 29, 2020
Atrophy Blood Glucose Brain Carotid Artery Diseases cerebral hemorrhage Cerebrovascular Disorders Diabetes mellitus Type 2 Genetic Predisposition to Disease Glycated Hemoglobin Humans Hyperglycemia Insulin Resistance Insulin-Secreting Cells ischemic stroke Mendelian Randomization Analysis white matter
Preliminary Results on the Online Lessons of IDPE Department of University of West Attica 2019-2020
Evangelos Papakitsos, Panagiotis Makrygiannis, Michail Papoutsidakis, Dimitrios Piromalis, Dimitrios Tseles
Jan 01, 2023
During the pandemic outbreak of COVID-19 in Greece that coincided with the spring semester of the year 2020, conventional face-to-face lessons presented a threat to public health. As a result, house confinement measures were...
Published by: IGI Global Scientific Publishing
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition.
Wing K Man, Bogachan Tahirbegi, Michail D Vrettas, Swapan Preet, Liming Ying, Michele Vendruscolo, Alfonso De Simone, Giuliana Fusco
Mar 30, 2021
α-Synuclein (αS) is a presynaptic disordered protein whose aberrant aggregation is associated with Parkinson's disease. The functional role of αS is still debated, although it has been involved in the regulation of...
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition
Wing K. Man, Bogachan Tahirbegi, Michail D. Vrettas, Swapan Preet, Liming Ying, Michele Vendruscolo, Alfonso De Simone, Giuliana Fusco
Feb 10, 2021
Abstract: α-Synuclein (αS) is a presynaptic disordered protein whose aberrant aggregation is associated with Parkinson’s disease. The functional role of αS is still debated, although it has been involved in the regulation of...
Periodic Trends in Adsorption Energies around Single-Atom Alloy Active Sites.
Julia Schumann, Yutian Bao, Ryan T Hannagan, E Charles H Sykes, Michail Stamatakis, Angelos Michaelides
Oct 25, 2021
Single-atom alloys (SAAs) make up a special class of alloy surface catalysts that offer well-defined, isolated active sites in a more inert metal host. The dopant sites are generally assumed to have little or no influence on the...
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