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Derivatives of a PARP inhibitor TIQ-A through synthesis of 8-alkoxythieno[2,3-c]isoquinolin-5(4H)-ones
Mirko Maksimainen, Antti Nurmesjärvi, Reima Terho, Michael Threadgill, Lari Lehtiö, Juha Heiskanen
Jan 01, 0001
Thieno[2,3-c]isoquinolin-5(4H)-one is known for its potential as an anti-ischemic agent through inhibition of poly(ADP-ribose) polymerase 1 (PARP1). However, the compound also inhibits many other enzymes of the PARP family...
Derivatives of a PARP inhibitor TIQ-A through synthesis of 8-alkoxythieno[2,3-c]isoquinolin-5(4H)-ones
Mirko Maksimainen, Antti Nurmesjärvi, Reima Terho, Michael Threadgill, Lari Lehtiö, Juha Heiskanen
Jan 01, 0001
Thieno[2,3-c]isoquinolin-5(4H)-one is known for its potential as an anti-ischemic agent through inhibition of poly(ADP-ribose) polymerase 1 (PARP1). However, the compound also inhibits many other enzymes of the PARP family...
Structural Coupling of Regulatory Elements and Reality Challenges
Mirko Pečarič
Apr 01, 2020
Different realities are possible and thus also different decisions. They are based on predispositions faced with different challenges that people (do not) acknowledge. The research objective is to point at differences when the...
Published by: IGI Global Scientific Publishing
Fully autonomous micro air vehicle flight and landing on a moving target using visual–inertial estimation and model‐predictive control
Dimos Tzoumanikas, Wenbin Li, Marius Grimm, Ketao Zhang, Mirko Kovac, Stefan Leutenegger
Jan 01, 2019
The Mohamed Bin Zayed International Robotics Challenge (MBZIRC) held in spring 2017 was a very successful competition well attended by teams from all over the world. One of the challenges (Challenge 1) required an aerial robot...
Women's leadership and the gendered consequences of austerity in the public sector
During times of economic turmoil, women often bear the cost of cuts in public spending and labor market deregulation. We argue that the adverse gendered consequences of austerity are mitigated when women occupy more political...
Fully autonomous micro air vehicle flight and landing on a moving target using visual–inertial estimation and model‐predictive control
Dimos Tzoumanikas, Wenbin Li, Marius Grimm, Ketao Zhang, Mirko Kovac, Stefan Leutenegger
Jan 01, 2019
The Mohamed Bin Zayed International Robotics Challenge (MBZIRC) held in spring 2017 was a very successful competition well attended by teams from all over the world. One of the challenges (Challenge 1) required an aerial robot...
Deposition dynamics and analysis of polyurethane foam structure boundaries for Aerial Additive Manufacturing
Barrie Dams, Lachlan Orr, Yusuf Furkan Kaya, Basaran Bahadir Kocer, Paul Shepherd, Mirko Kovac, Richard Ball
Jan 22, 2024
Additive manufacturing in construction typically consists of ground-based platforms. Introducing aerial capabilities offers scope to create or repair structures in dangerous or elevated locations. The Aerial Additive...
Bioinspired design of a landing system with soft shock absorbers for autonomous aerial robots
Ketao Zhang, Pisak Chermprayong, Dimos Tzoumanikas, Wenbin Li, Marius Grimm, Mariusz Smentoch, Stefan Leutenegger, Mirko Kovac
Dec 22, 2018
One of the main challenges for autonomous aerial robots is to land safely on a target position on varied surface structures in real‐world applications. Most of current aerial robots (especially multirotors) use only rigid...
Ab initio nonrigid X-ray nanotomography.
Michal Odstrcil, Mirko Holler, Jörg Raabe, Alessandro Sepe, Xiaoyuan Sheng, Silvia Vignolini, Christian G Schroer, Manuel Guizar-Sicairos
Aug 21, 2019
Reaching the full potential of X-ray nanotomography, in particular for biological samples, is limited by many factors, of which one of the most serious is radiation damage. Although sample deformation caused by radiation damage...
Deposition dynamics and analysis of polyurethane foam structure boundaries for Aerial Additive Manufacturing
Barrie Dams, Lachlan Orr, Yusuf Furkan Kaya, Basaran Bahadir Kocer, Paul Shepherd, Mirko Kovac, Richard Ball
Jan 22, 2024
Additive manufacturing in construction typically consists of ground-based platforms. Introducing aerial capabilities offers scope to create or repair structures in dangerous or elevated locations. The Aerial Additive...
Focus on ROS1-Positive Non-Small Cell Lung Cancer (NSCLC)
Alberto D'Angelo, Navid Sobhani, Robert Chapman, Stefan Bagby, Carlotta Bortoletti, Mirko Traversini, Katia Ferrari, Luca Voltolini, Jacob Darlow, Giandomenico Roviello
Nov 06, 2020
The treatment of patients affected by non-small cell lung cancer (NSCLC) has been revolutionised by the discovery of druggable mutations. ROS1 (c-ros oncogene) is one gene with druggable mutations in NSCLC. ROS1 is currently...
Focus on ROS1-Positive Non-Small Cell Lung Cancer (NSCLC)
Alberto D'Angelo, Navid Sobhani, Robert Chapman, Stefan Bagby, Carlotta Bortoletti, Mirko Traversini, Katia Ferrari, Luca Voltolini, Jacob Darlow, Giandomenico Roviello
Nov 06, 2020
The treatment of patients affected by non-small cell lung cancer (NSCLC) has been revolutionised by the discovery of druggable mutations. ROS1 (c-ros oncogene) is one gene with druggable mutations in NSCLC. ROS1 is currently...
Ab initio nonrigid X-ray nanotomography
Michal Odstrcil, Mirko Holler, Jörg Raabe, Alessandro Sepe, Xiaoyuan Sheng, Silvia Vignolini, Christian G. Schroer, Manuel Guizar-Sicairos
Jun 12, 2020
Abstract: Reaching the full potential of X-ray nanotomography, in particular for biological samples, is limited by many factors, of which one of the most serious is radiation damage. Although sample deformation caused by...
Bioinspired design of a landing system with soft shock absorbers for autonomous aerial robots
Ketao Zhang, Pisak Chermprayong, Dimos Tzoumanikas, Wenbin Li, Marius Grimm, Mariusz Smentoch, Stefan Leutenegger, Mirko Kovac
Dec 22, 2018
One of the main challenges for autonomous aerial robots is to land safely on a target position on varied surface structures in real‐world applications. Most of current aerial robots (especially multirotors) use only rigid...
A resource of vectors and ES cells for targeted deletion of microRNAs in mice.
The 21-23 nucleotide, single-stranded RNAs classified as microRNAs (miRNA) perform fundamental roles in diverse cellular and developmental processes. In contrast to the situation for protein-coding genes, no public resource of...
Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat.
Damir Omerbašić, Ewan St J Smith, Mirko Moroni, Johanna Homfeld, Ole Eigenbrod, Nigel C Bennett, Jane Reznick, Chris G Faulkes, Matthias Selbach, Gary R Lewin
Nov 07, 2016
calcium imaging capsaicin receptor Electrophysiology Hyperalgesia Nerve Growth Factor nociceptor development receptor kinase signaling sensitization transcriptome assembly Animals Ganglia Spinal HEK293 Cells Humans Ion Channel Gating Mole Rats Nerve Growth Factor Neurons Nociceptors Pain Protein Domains Proteomics Receptor trkA TRPV Cation Channels
Evolutionary-Optimized Photonic Network Structure in White Beetle Wing Scales.
Mechanical adaptation of brachiopod shells via hydration-induced structural changes.
Johannes Ihli, Anna S Schenk, Sabine Rosenfeldt, Klaus Wakonig, Mirko Holler, Giuseppe Falini, Luca Pasquini, Eugénia Delacou, Jim Buckman, Thomas S Glen, Thomas Kress, Esther H R Tsai, David G Reid, Melinda J Duer, Maggie Cusack, Fabio Nudelman
Oct 13, 2021
The function-optimized properties of biominerals arise from the hierarchical organization of primary building blocks. Alteration of properties in response to environmental stresses generally involves time-intensive processes of...
Published by: Nature Communications
Convergent evolution and topologically disruptive polymorphisms among multidrug-resistant tuberculosis in Peru.
Louis Grandjean, Robert H Gilman, Tomatada Iwamoto, Claudio U Köser, Jorge Coronel, Mirko Zimic, M Estee Török, Diepreye Ayabina, Michelle Kendall, Christophe Fraser, Simon Harris, Julian Parkhill, Sharon J Peacock, David AJ Moore, Caroline Colijn
Jun 26, 2018
BACKGROUND: Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic and...
Imaging Cu2O nanocube hollowing in solution by quantitative in situ X-ray ptychography.
Lukas Grote, Martin Seyrich, Ralph Döhrmann, Sani Y Harouna-Mayer, Federica Mancini, Emilis Kaziukenas, Irene Fernandez-Cuesta, Cecilia A Zito, Olga Vasylieva, Felix Wittwer, Michal Odstrčzil, Natnael Mogos, Mirko Landmann, Christian G Schroer, Dorota Koziej
Sep 02, 2022
Understanding morphological changes of nanoparticles in solution is essential to tailor the functionality of devices used in energy generation and storage. However, we lack experimental methods that can visualize these processes...
Imaging Cu2O nanocube hollowing in solution by quantitative in situ X-ray ptychography.
Lukas Grote, Martin Seyrich, Ralph Döhrmann, Sani Y Harouna-Mayer, Federica Mancini, Emilis Kaziukenas, Irene Fernandez-Cuesta, Cecilia A Zito, Olga Vasylieva, Felix Wittwer, Michal Odstrčzil, Natnael Mogos, Mirko Landmann, Christian G Schroer, Dorota Koziej
Sep 29, 2022
Understanding morphological changes of nanoparticles in solution is essential to tailor the functionality of devices used in energy generation and storage. However, we lack experimental methods that can visualize these processes...
Mechanical adaptation of brachiopod shells via hydration-induced structural changes
Johannes Ihli, Anna S. Schenk, Sabine Rosenfeldt, Klaus Wakonig, Mirko Holler, Giuseppe Falini, Luca Pasquini, Eugénia Delacou, Jim Buckman, Thomas S. Glen, Thomas Kress, Esther H. R. Tsai, David G. Reid, Melinda J. Duer, Maggie Cusack, Fabio Nudelman
Sep 10, 2021
Abstract: The function-optimized properties of biominerals arise from the hierarchical organization of primary building blocks. Alteration of properties in response to environmental stresses generally involves time-intensive...
Mechanical adaptation of brachiopod shells via hydration-induced structural changes.
Johannes Ihli, Anna S Schenk, Sabine Rosenfeldt, Klaus Wakonig, Mirko Holler, Giuseppe Falini, Luca Pasquini, Eugénia Delacou, Jim Buckman, Thomas S Glen, Thomas Kress, Esther HR Tsai, David G Reid, Melinda J Duer, Maggie Cusack, Fabio Nudelman
Nov 09, 2021
The function-optimized properties of biominerals arise from the hierarchical organization of primary building blocks. Alteration of properties in response to environmental stresses generally involves time-intensive processes of...
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