GWAS of epigenetic aging rates in blood reveals a critical role for TERT.
Ake T Lu,
Luting Xue,
Elias L Salfati,
Brian H Chen,
Luigi Ferrucci,
Daniel Levy,
Roby Joehanes,
Joanne M Murabito,
Douglas P Kiel,
Pei-Chien Tsai,
Idil Yet,
Jordana T Bell,
Massimo Mangino,
Toshiko Tanaka,
Allan F McRae,
Riccardo E Marioni,
Peter M Visscher,
Naomi R Wray,
Ian J Deary,
Morgan E Levine,
Austin Quach,
Themistocles Assimes,
Philip S Tsao,
Devin Absher,
James D Stewart,
Yun Li,
Alex P Reiner,
Lifang Hou,
Andrea A Baccarelli,
Eric A Whitsel,
Abraham Aviv,
Alexia Cardona,
Felix R Day,
Nicholas J Wareham,
John RB Perry,
Ken K Ong,
Kenneth Raj,
Kathryn L Lunetta,
Steve Horvath
Apr 13, 2018
DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its underlying molecular mechanisms are unknown. In this genome-wide association study of 9907 individuals, we find gene variants...