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The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.
Han Seok Koh, Chi Young Chang, Sae-Bom Jeon, Hee Jung Yoon, Ye-Hyeon Ahn, Hyung-Seok Kim, In-Hoo Kim, Sung Ho Jeon, Randall S Johnson, Eun Jung Park
Mar 13, 2020
Inflammation is closely related to the extent of damage following cerebral ischaemia, and the targeting of this inflammation has emerged as a promising therapeutic strategy. Here, we present that hypoxia-induced glial T-cell...
Animals Astrocytes Brain Carotid Artery Common Cell Movement Cells Cultured Hepatitis A Virus Cellular Receptor 2 Hypoxia-Inducible Factor 1 alpha Subunit Hypoxia-Ischemia Brain Immunohistochemistry In Vitro Techniques Inflammation Ligation Magnetic Resonance Imaging Mesencephalon Mice Microglia Neuroglia Neutrophils RNA Messenger Receptors Virus Reverse Transcriptase Polymerase Chain Reaction
IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients
R Tallerico, CM Cristiani, E Staaf, C Garofalo, R Sottile, M Capone, Y Pico de Coaña, G Madonna, E Palella, M Wolodarski, V Carannante, D Mallardo, E Simeone, AM Grimaldi, S Johansson, P Frumento, E Gulletta, A Anichini, F Colucci, G Ciliberto, R Kiessling, K Kärre, PA Ascierto, E Carbone
Jul 20, 2017
Despite the success of immune checkpoint blockade in melanoma, the majority of patients do not respond. We hypothesized that the T and NK cell subset frequencies and expression levels of their receptors may predict responses and...
Governor Appoints Don Long and Tim Hopkins to Winthrop Board of Trustees
Winthrop University
Jan 01, 0001
Don Long of Lake Wylie will fill the appointee slot held by Tommy Pope, who was elected to the S.C. House of Representatives in November and had to resign. Tim Hopkins, an executive director of elementary education in the...
Published by: Winthrop University
Practitioner Review
Important advances in understanding traumatic stress reactions in children and young people have been made in recent years. The aim of this review was to synthesise selected recent research findings, with a focus on their...
Reduced social risk-taking in depression.
Evolutionary models of depression posit that depressed mood represents an adaptive response to unacceptably low social status, motivating the inhibition of social risk-taking in favor of submissive behaviors which reduce the...
Negative and positive emotional complexity in the autobiographical representations of sexual trauma survivors.
This study examined the diversity of experienced positive and negative emotions - emodiversity - within two existing datasets involving female survivors of sexual abuse and assault, who all met criteria for chronic Posttraumatic...
Psychology Professor Tim Daugherty Elected as New Chair of Faculty Conference
Winthrop University
Jan 01, 0001
Tim Daugherty, an associate professor of psychology in the College of Arts and Sciences, will replace Marilyn Smith, a professor of business administration who has served since 2002. He will become the faculty chair in July...
Published by: Winthrop University
Systematic Review and Meta-analysis
OBJECTIVE: Trauma exposure is common in preschool-aged children. Understanding the psychological impact of such exposure and the prevalence of posttraumatic stress disorder (PTSD) in this population is important for provision of...
Transdiagnostic approaches to mental health problems
Despite a longstanding and widespread influence of the diagnostic approach to mental ill health, there is an emerging and growing consensus that such psychiatric nosologies may no longer be fit for purpose in research and...
Prevalence of auditory pseudohallucinations in adult survivors of physical and sexual trauma with chronic post-traumatic stress disorder (PTSD).
Auditory Verbal Hallucinations (AVHs) are commonly associated with psychosis but are also reported in post-traumatic stress disorder (PTSD). Hearing voices after the experience of stress has been conceptualised as a dissociative...
Auditory verbal hallucinations Dissociation hearing voices PTSD Pseudohallucinations Adolescent Adult Adult Survivors of Child Abuse Case-Control Studies Chronic Disease Comorbidity Female Hallucinations Humans Male Middle Aged prevalence Sex Offenses Stress Disorders Post-Traumatic Survivors United Kingdom Young Adult
Compartmentalization of self-representations in female survivors of sexual abuse and assault, with posttraumatic stress disorder (PTSD).
BACKGROUND: This study examined the structure of the self-concept in a sample of sexual trauma survivors with posttraumatic stress disorder (PTSD) compared to healthy controls using a self-descriptive card-sorting task. We...
Disrupted Dorsal Mid-Insula Activation During Interoception Across Psychiatric Disorders.
OBJECTIVE: Maintenance of bodily homeostasis relies on interoceptive mechanisms in the brain to predict and regulate bodily state. While altered neural activation during interoception in specific psychiatric disorders has been...
Misremembrance of Things Past
Caitlin Hitchcock, Evangeline Rodrigues, Catrin Rees, Siobhan Gormley, Barbara Dritschel, Tim Dalgleish
Mar 25, 2019
Impaired retrieval of specific, autobiographical memories of personally experienced events is characteristic of major depressive disorder (MDD). However, findings in subclinical samples suggest that the reduced specificity...
A Causal Role for Gastric Rhythm in Human Disgust Avoidance.
Rotten food, maggots, bodily waste-all elicit disgust in humans. Disgust promotes survival by encouraging avoidance of disease vectors1 but is also implicated in prejudice toward minority groups; avoidance of environmentally...
Protocol for the Work Engagement and Well-being Study (SWELL)
INTRODUCTION: Mental ill health is a major cause of disability. Workplaces are attractive for preventative interventions since most adults work; meanwhile, employers are interested in improving employees' well-being and...
The devil's in the detail
Models of memory propose that separate systems underpin the storage and recollection of specific events from our past (e.g., the first day at school), and of the generic structure of our experiences (e.g., how lonely I am), and...
Fractured Pasts
We examined the organization of past and future affective autobiographical knowledge in sexual-trauma survivors compared with control participants. Participants (N = 113) divided their past (and future) life into chapters (e.g....
Proof of Concept for the Autobiographical Memory Flexibility (MemFlex) Intervention for Posttraumatic Stress Disorder.
Ali Reza Moradi, Maryam Piltan, Mohammad Hasan Choobin, Parviz Azadfallah, Peter Watson, Tim Dalgleish, Caitlin Hitchcock
Oct 29, 2020
Autobiographical memory distortions are a key feature of posttraumatic stress disorder (PTSD). In this proof-of-concept randomized controlled trial (N = 43), we evaluated an autobiographical memory flexibility intervention...
Moral Chivalry
Oriel FeldmanHall, Tim Dalgleish, Davy Evans, Lauren Navrady, Ellen Tedeschi, Dean Mobbs
Jan 21, 2020
Moral perceptions of harm and fairness are instrumental in guiding how an individual navigates moral challenges. Classic research documents that the gender of a target can affect how people deploy these perceptions of harm and...
Age-related decline in positive emotional reactivity and emotion regulation in a population-derived cohort.
Susanne Schweizer, Jason Stretton, Janna Van Belle, Darren Price, Andrew J Calder, Cam-CAN, Tim Dalgleish
Jun 20, 2019
Human older age ushers in functional decline across the majority of cognitive domains. A notable exception seems to be affective processing, with older people reporting higher levels of emotional well-being. Here we evaluated...
A core role for cognitive processes in the acute onset and maintenance of post-traumatic stress in children and adolescents.
Richard Meiser-Stedman, Anna McKinnon, Clare Dixon, Adrian Boyle, Patrick Smith, Tim Dalgleish
Mar 27, 2019
BACKGROUND: Post-traumatic stress disorder (PTSD) is a common reaction to trauma in children and adolescents. While a significant minority of trauma-exposed youth go on to have persistent PTSD, many youths who initially have a...
Autobiographical episodic memory-based training for the treatment of mood, anxiety and stress-related disorders
We review evidence for training programmes that manipulate autobiographical processing in order to treat mood, anxiety, and stress-related disorders, using the GRADE criteria to judge evidence quality. We also position the...
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