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Results: 26
Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site.
Marijke Brams, Cedric Govaerts, Kumiko Kambara, Kerry L Price, Radovan Spurny, Anant Gharpure, Els Pardon, Genevieve L Evans, Daniel Bertrand, Sarah CR Lummis, Ryan E Hibbs, Jan Steyaert, Chris Ulens
Feb 28, 2020
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but...
human neuroscience allosteric modulation structural biology Ligand-Gated Ion Channels molecular biophysics
Published by: eLife
TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells.
Anna Osnato, Stephanie Brown, Christel Krueger, Simon Andrews, Amanda J Collier, Shota Nakanoh, Mariana Quiroga Londoño, Brandon T Wesley, Daniele Muraro, A Sophie Brumm, Kathy K Niakan, Ludovic Vallier, Daniel Ortmann, Peter J Rugg-Gunn
Oct 01, 2021
Published by: eLife
An oomycete effector subverts host vesicle trafficking to channel starvation-induced autophagy to the pathogen interface.
Pooja Pandey, Alexandre Y Leary, Yasin Tumtas, Zachary Savage, Bayantes Dagvadorj, Cian Duggan, Enoch LH Yuen, Nattapong Sanguankiattichai, Emily Tan, Virendrasinh Khandare, Amber J Connerton, Temur Yunusov, Mathias Madalinski, Federico Gabriel Mirkin, Sebastian Schornack, Yasin Dagdas, Sophien Kamoun, Tolga O Bozkurt
Sep 23, 2021
Eukaryotic cells deploy autophagy to eliminate invading microbes. In turn, pathogens have evolved effector proteins to counteract antimicrobial autophagy. How adapted pathogens co-opt autophagy for their own benefit is poorly...
haustorium Phytophthora infestans Nicotiana benthamiana Autophagy plant biology autophagy inhibition
Published by: eLife
Localised dynactin protects growing microtubules to deliver oskar mRNA to the posterior cortex of the Drosophila oocyte.
Ross Nieuwburg, Dmitry Nashchekin, Maximilian Jakobs, Andrew P Carter, Philipp Khuc Trong, Raymond Goldstein, Robert St Johnston
May 03, 2018
© Nieuwburg et al. The localisation of oskar mRNA to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Kinesin 1 transports oskar mRNA to the oocyte posterior along a polarised...
Oocytes Microtubules Animals Drosophila melanogaster Kinesin Cytoskeletal Proteins Drosophila Proteins RNA Messenger
Published by: eLife
Cardiac mitochondrial function depends on BUD23 mediated ribosome programming.
Matthew Baxter, Maria Voronkov, Toryn Poolman, Gina Galli, Christian Pinali, Laurence Goosey, Abigail Knight, Karolina Krakowiak, Robert Maidstone, Mudassar Iqbal, Min Zi, Sukhpal Prehar, Elizabeth J Cartwright, Julie Gibbs, Laura C Matthews, Antony D Adamson, Neil E Humphreys, Pedro Rebelo-Guiomar, Michal Minczuk, David A Bechtold, Andrew Loudon, David Ray
Feb 15, 2020
Efficient mitochondrial function is required in tissues with high energy demand such as the heart, and mitochondrial dysfunction is associated with cardiovascular disease. Expression of mitochondrial proteins is tightly...
Published by: eLife
Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis.
Alison L Kearney, Dougall M Norris, Milad Ghomlaghi, Martin Kin Lok Wong, Sean J Humphrey, Luke Carroll, Guang Yang, Kristen C Cooke, Pengyi Yang, Thomas A Geddes, Sungyoung Shin, Daniel J Fazakerley, Lan K Nguyen, David E James, James G Burchfield
Aug 13, 2021
The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-stimulated recruitment of Akt to the plasma...
human Insulin Cell Biology Phosphorylation Signal Transduction MOUSE plasma membrane Systems Biology Computational Biology PI3K Akt
Published by: eLife
Resegmentation is an ancestral feature of the gnathostome vertebral skeleton.
The vertebral skeleton is a defining feature of vertebrate animals. However, the mode of vertebral segmentation varies considerably between major lineages. In tetrapods, adjacent somite halves recombine to form a single vertebra...
evolution Segmentation developmental biology vertebrae evolutionary biology axial skeleton chondrichthyan Somites
Published by: eLife
Impact of COVID-19-related disruptions to measles, meningococcal A, and yellow fever vaccination in 10 countries.
Katy AM Gaythorpe, Kaja Abbas, John Huber, Andromachi Karachaliou, Niket Thakkar, Kim Woodruff, Xiang Li, Susy Echeverria-Londono, Matthew Ferrari, Michael L Jackson, Kevin McCarthy, T Alex Perkins, Caroline Trotter, Mark Jit
Jul 28, 2021
Background
Childhood immunisation services have been disrupted by the COVID-19 pandemic. WHO recommends considering outbreak risk using epidemiological criteria when deciding whether to conduct preventive vaccination...
human Vaccination Medicine EPIDEMIOLOGY Measles Yellow Fever Global Health Meningococcal disease Mathematical modelling covid-19 Humans Meningococcal Infections Meningococcal Vaccines Measles Vaccine Yellow Fever Vaccine Risk Assessment Disease Outbreaks Adolescent Adult Child Child Preschool Infant Immunization Programs Africa Bangladesh Young Adult Pandemics covid-19 SARS-CoV-2
Published by: eLife
Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 world.
Jaspreet Toor, Susy Echeverria-Londono, Xiang Li, Kaja Abbas, Emily D Carter, Hannah E Clapham, Andrew Clark, Margaret J de Villiers, Kirsten Eilertson, Matthew Ferrari, Ivane Gamkrelidze, Timothy B Hallett, Wes R Hinsley, Daniel Hogan, John H Huber, Michael L Jackson, Kevin Jean, Mark Jit, Andromachi Karachaliou, Petra Klepac, Alicia Kraay, Justin Lessler, Xi Li, Benjamin A Lopman, Tewodaj Mengistu, C Jessica E Metcalf, Sean M Moore, Shevanthi Nayagam, Timos Papadopoulos, T Alex Perkins, Allison Portnoy, Homie Razavi, Devin Razavi-Shearer, Stephen Resch, Colin Sanderson, Steven Sweet, Yvonne Tam, Hira Tanvir, Quan Tran Minh, Caroline L Trotter, Shaun A Truelove, Emilia Vynnycky, Neff Walker, Amy Winter, Kim Woodruff, Neil M Ferguson, Katy AM Gaythorpe
Aug 13, 2021
Background
Vaccination is one of the most effective public health interventions. We investigate the impact of vaccination activities for Haemophilus influenzae type b, hepatitis B, human papillomavirus, Japanese...
Virus EPIDEMIOLOGY Global Health LMICs vaccine impact Mathematical modelling Humans Bacterial Infections Bacterial Vaccines SARS-CoV-2 Models Biological covid-19
Published by: eLife
Multiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya.
Samuel Kariuki, Zoe A Dyson, Cecilia Mbae, Ronald Ngetich, Susan M Kavai, Celestine Wairimu, Stephen Anyona, Naomi Gitau, Robert Sanaya Onsare, Beatrice Ongandi, Sebastian Duchene, Mohamed Ali, John David Clemens, Kathryn E Holt, Gordon Dougan
Oct 18, 2021
Background
Understanding the dynamics of infection and carriage of typhoid in endemic settings is critical to finding solutions to prevention and control.Methods
In a 3-year case-control study, we investigated...
microbiology children infectious disease EPIDEMIOLOGY Kenya typhoid Global Health carriage multidrug-resistant S. enterica serovar typhi H58 lineages
Published by: eLife
Human embryo polarization requires PLC signaling to mediate trophectoderm specification.
Meng Zhu, Marta Shahbazi, Angel Martin, Chuanxin Zhang, Berna Sozen, Mate Borsos, Rachel S Mandelbaum, Richard J Paulson, Matteo A Mole, Marga Esbert, Shiny Titus, Richard T Scott, Alison Campbell, Simon Fishel, Viviana Gradinaru, Han Zhao, Keliang Wu, Zi-Jiang Chen, Emre Seli, Maria J de los Santos, Magdalena Zernicka Goetz
Oct 28, 2021
Published by: eLife
An ABA-GA bistable switch can account for natural variation in the variability of Arabidopsis seed germination time.
Katie Abley, Pau Formosa-Jordan, Hugo Tavares, Emily YT Chan, Mana Afsharinafar, Ottoline Leyser, James CW Locke
Jul 05, 2021
Genetically identical plants growing in the same conditions can display heterogeneous phenotypes. Here we use Arabidopsis seed germination time as a model system to examine phenotypic variability and its underlying mechanisms....
germination variability ABA GA Systems Biology Computational Biology quantitative genetics plant biology Mathematical modelling A. thaliana
Published by: eLife
Patterns of within-host genetic diversity in SARS-CoV-2.
Gerry Tonkin-Hill, Inigo Martincorena, Roberto Amato, Andrew RJ Lawson, Moritz Gerstung, Ian Johnston, David K Jackson, Naomi Park, Stefanie V Lensing, Michael A Quail, Sónia Gonçalves, Cristina Ariani, Michael Spencer Chapman, William L Hamilton, Luke W Meredith, Grant Hall, Aminu S Jahun, Yasmin Chaudhry, Myra Hosmillo, Malte L Pinckert, Iliana Georgana, Anna Yakovleva, Laura G Caller, Sarah L Caddy, Theresa Feltwell, Fahad A Khokhar, Charlotte J Houldcroft, Martin D Curran, Surendra Parmar, Alex Alderton, Rachel Nelson, Ewan M Harrison, John Sillitoe, Stephen D Bentley, Jeffrey C Barrett, M Estee Torok, Ian G Goodfellow, Cordelia Langford, Dominic Kwiatkowski
Sep 13, 2021
Monitoring the spread of SARS-CoV-2 and reconstructing transmission chains has become a major public health focus for many governments around the world. The modest mutation rate and rapid transmission of SARS-CoV-2 prevents the...
Genetics transmission Genomics EPIDEMIOLOGY Global Health within-host SARS-CoV-2 mutational spectrum Humans Phylogeny Base Sequence Mutation Genome Viral Host-Pathogen Interactions genetic variation Pandemics covid-19 SARS-CoV-2
Published by: eLife
BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion.
Vicente Perez-Garcia, Georgia Lea, Pablo Lopez-Jimenez, Hanneke Okkenhaug, Graham J Burton, Ashley Moffett, Margherita Y Turco, Myriam Hemberger
Jul 28, 2021
Normal function of the placenta depends on the earliest developmental stages when trophoblast cells differentiate and invade into the endometrium to establish the definitive maternal-fetal interface. Previously, we identified...
human Placenta trophoblast MOUSE trophoblast invasion developmental biology Stem Cells Epithelial-Mesenchymal Transition Regenerative Medicine stem cell self-renewal CRISPR gene editing
Published by: eLife
An in vitro stem cell model of human epiblast and yolk sac interaction.
Kirsty ML Mackinlay, Bailey AT Weatherbee, Viviane Souza Rosa, Charlotte E Handford, George Hudson, Tim Coorens, Lygia V Pereira, Sam Behjati, Ludovic Vallier, Marta N Shahbazi, Magdalena Zernicka-Goetz
Sep 17, 2021
Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct morphogenesis within the human embryo remains largely unknown due to a lack of...
human Cell Biology embryology MOUSE Pluripotency developmental biology Stem Cells human development Epiblast hypoblast
Published by: eLife
Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time.
A Sarah Walker, Emma Pritchard, Thomas House, Julie V Robotham, Paul J Birrell, Iain Bell, John I Bell, John N Newton, Jeremy Farrar, Ian Diamond, Ruth Studley, Jodie Hay, Karina-Doris Vihta, Timothy EA Peto, Nicole Stoesser, Philippa C Matthews, David W Eyre, Koen B Pouwels
Aug 12, 2021
microbiology community infectious disease Medicine Viral Load Symptoms SARS-CoV-2 Humans Viral Load covid-19 SARS-CoV-2 COVID-19 Testing
Published by: eLife
Polypyrimidine tract-binding proteins are essential for B cell development.
Elisa Monzón-Casanova, Louise S Matheson, Kristina Tabbada, Kathi Zarnack, Christopher WJ Smith, Martin Turner
Mar 25, 2020
Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We...
Cell Cycle MOUSE Alternative Splicing Inflammation Chromosomes immunology Gene Expression RNA-Binding Proteins B Cell Development
Published by: eLife
eLife's new model and its impact on science communication.
Lara Urban, Mariana De Niz, Florencia Fernández-Chiappe, Hedyeh Ebrahimi, Laura K M Han, Devang Mehta, Regina Mencia, Divyansh Mittal, Elizabeth Ochola, Carolina Paz Quezada, Facundo Romani, Lana Sinapayen, Andy Tay, Aalok Varma, Lamis Yahia Mohamed Elkheir
Jan 07, 2023
The eLife Early-Career Advisory Group discusses eLife's new peer review and publishing model, and how the whole process of scientific communication could be improved for the benefit of early-career researchers and the entire...
Peer review scientific publishing None Point of View Research Assessment Early-career Researchers Preprints communication
Published by: eLife
An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression.
Polona Safaric Tepes, Debjani Pal, Trine Lindsted, Ingrid Ibarra, Amaia Lujambio, Vilma Jimenez Sabinina, Serif Senturk, Madison Miller, Navya Korimerla, Jiahao Huang, Lawrence Glassman, Paul Lee, David Zeltsman, Kevin Hyman, Michael Esposito, Gregory J Hannon, Raffaella Sordella
Aug 13, 2021
Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents...
Published by: eLife
β-hydroxybutyrate accumulates in the rat heart during low-flow ischaemia with implications for functional recovery.
Ross T Lindsay, Sophie Dieckmann, Dominika Krzyzanska, Dominic Manetta-Jones, James A West, Cecilia Castro, Julian L Griffin, Andrew J Murray
Oct 08, 2021
Extrahepatic tissues which oxidise ketone bodies also have the capacity to accumulate them under particular conditions. We hypothesised that acetyl-coenzyme A (acetyl-CoA) accumulation and altered redox status during low-flow...
Published by: eLife
Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in <i>Drosophila</i>.
Sebastian Hückesfeld, Philipp Schlegel, Anton Miroschnikow, Andreas Schoofs, Ingo Zinke, André N Haubrich, Casey M Schneider-Mizell, James W Truman, Richard D Fetter, Albert Cardona, Michael J Pankratz
Jul 28, 2021
Neuroendocrine systems in animals maintain organismal homeostasis and regulate stress response. Although a great deal of work has been done on the neuropeptides and hormones that are released and act on target organs in the...
Carbon Dioxide Neuropeptides neuroscience interneuron neuroendocrine system Connectome D. melanogaster sensory synapses
Published by: eLife
<i>Cortex cis</i>-regulatory switches establish scale colour identity and pattern diversity in <i>Heliconius</i>.
Luca Livraghi, Joseph J Hanly, Steven M Van Bellghem, Gabriela Montejo-Kovacevich, Eva SM van der Heijden, Ling Sheng Loh, Anna Ren, Ian A Warren, James J Lewis, Carolina Concha, Laura Hebberecht, Charlotte J Wright, Jonah M Walker, Jessica Foley, Zachary H Goldberg, Henry Arenas-Castro, Camilo Salazar, Michael W Perry, Riccardo Papa, Arnaud Martin, W Owen McMillan, Chris D Jiggins
Aug 26, 2021
In Heliconius butterflies, wing colour pattern diversity and scale types are controlled by a few genes of large effect that regulate colour pattern switches between morphs and species across a large mimetic radiation. One...
evolution developmental biology evolutionary biology Cis-regulation Heliconius ATAC-seq wing patterning crisppr
Published by: eLife
Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections.
Christopher JR Illingworth, William L Hamilton, Ben Warne, Matthew Routledge, Ashley Popay, Chris Jackson, Tom Fieldman, Luke W Meredith, Charlotte J Houldcroft, Myra Hosmillo, Aminu S Jahun, Laura G Caller, Sarah L Caddy, Anna Yakovleva, Grant Hall, Fahad A Khokhar, Theresa Feltwell, Malte L Pinckert, Iliana Georgana, Yasmin Chaudhry, Martin D Curran, Surendra Parmar, Dominic Sparkes, Lucy Rivett, Nick K Jones, Sushmita Sridhar, Sally Forrest, Tom Dymond, Kayleigh Grainger, Chris Workman, Mark Ferris, Effrossyni Gkrania-Klotsas, Nicholas M Brown, Michael P Weekes, Stephen Baker, Sharon J Peacock, Ian G Goodfellow, Theodore Gouliouris, Daniela De Angelis, M Estée Török
Sep 24, 2021
SARS-CoV-2 is notable both for its rapid spread, and for the heterogeneity of its patterns of transmission, with multiple published incidences of superspreading behaviour. Here, we applied a novel network reconstruction...
Virus microbiology infectious disease hospital evolutionary biology nosocomial transmission superspreader SARS-CoV-2 Humans Retrospective Studies Disease Outbreaks Middle Aged Hospitals Female Male covid-19
Published by: eLife
Visualizing formation of the active site in the mitochondrial ribosome.
Viswanathan Chandrasekaran, Nirupa Desai, Nicholas O Burton, Hanting Yang, Jon Price, Eric A Miska, V Ramakrishnan
Nov 05, 2021
human Biochemistry C. elegans structural biology chemical biology cryo-EM RNA modifications peptidyl transferase center molecular biophysics mitochondrial ribosome
Published by: eLife
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