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Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells.
Laura M Nolan, Amy K Cain, Thomas Clamens, R Christopher D Furniss, Eleni Manoli, Maria A Sainz-Polo, Gordon Dougan, David Albesa-Jové, Julian Parkhill, Despoina A I Mavridou, Alain Filloux
Sep 20, 2021
The Type VI secretion system (T6SS) is a bacterial nanomachine that delivers toxic effectors to kill competitors or subvert some of their key functions. Here, we use transposon directed insertion-site sequencing to identify T6SS...
Pseudomonas aeruginosa Multiprotein Complexes Bacterial Proteins Bacterial Toxins Protein Biosynthesis Protein Binding Type VI Secretion Systems
Published by: Nature microbiology