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Results: 7
Developing ovine mammary terminal duct lobular units have a dynamic mucosal and stromal immune microenvironment
Dorottya Nagy, Clare M. C. Gillis, Katie Davies, Abigail L. Fowden, Paul Rees, John W. Wills, Katherine Hughes
Aug 26, 2021
Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice
Daniela de Barros Mucci, Laura C. Kusinski, Phoebe Wilsmore, Elena Loche, Lucas C. Pantaleão, Thomas J. Ashmore, Heather L. Blackmore, Denise S. Fernandez-Twinn, Maria das Graças T. do Carmo, Susan E. Ozanne
Mar 13, 2021
Abstract: Background: In utero exposure to obesity is consistently associated with increased risk of metabolic disease, obesity and cardiovascular dysfunction in later life despite the divergence of birth weight outcomes. The...
Automated optimisation of solubility and conformational stability of antibodies and proteins
Angelo Rosace, Anja Bennett, Marc Oeller, Mie M Mortensen, Laila Sakhnini, Nikolai Lorenzen, Christian Poulsen, Pietro Sormanni
Apr 07, 2023
Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2.
Kuan-Ying A Huang, Xiaorui Chen, Arpita Mohapatra, Hong Thuy Vy Nguyen, Lisa Schimanski, Tiong Kit Tan, Pramila Rijal, Susan K Vester, Rory A Hills, Mark Howarth, Jennifer R Keeffe, Alexander A Cohen, Leesa M Kakutani, Yi-Min Wu, Md Shahed-Al-Mahmud, Yu-Chi Chou, Pamela J Bjorkman, Alain R Townsend, Che Ma
Jan 19, 2023
Antibody-mediated immunity plays a crucial role in protection against SARS-CoV-2 infection. We isolated a panel of neutralizing anti-receptor-binding domain (RBD) antibodies elicited upon natural infection and vaccination and...
Biotin proximity tagging favours unfolded proteins and enables the study of intrinsically disordered regions
Abstract: Intrinsically Disordered Regions (IDRs) are enriched in disease-linked proteins known to have multiple post-translational modifications, but there is limited in vivo information about how locally unfolded protein...
Menstrual flow as a non-invasive source of endometrial organoids
Tereza Cindrova-Davies, Xiaohui Zhao, Kay Elder, Carolyn J. P. Jones, Ashley Moffett, Graham J. Burton, Margherita Y. Turco
Jun 18, 2021
Biotin proximity tagging favours unfolded proteins and enables the study of intrinsically disordered regions
Abstract: Intrinsically Disordered Regions (IDRs) are enriched in disease-linked proteins known to have multiple post-translational modifications, but there is limited in vivo information about how locally unfolded protein...