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The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s
Hale Tunbak, Rocio Enriquez-Gasca, Christopher H. C. Tie, Poppy A. Gould, Petra Mlcochova, Ravindra K. Gupta, Liane Fernandes, James Holt, Annemarthe G. van der Veen, Evangelos Giampazolias, Kathleen H. Burns, Pierre V. Maillard, Helen M. Rowe
Nov 03, 2020
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.
Germán Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Jan 28, 2022
RNF43/ZNRF3 negatively regulate WNT signalling. Both genes are mutated in several types of cancers, however, their contribution to liver disease is unknown. Here we describe that hepatocyte-specific loss of Rnf43/Znrf3 results...
Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions
Alexander C. W. Smith, Sietse Jonkman, Alexandra G. Difeliceantonio, Richard M. O’Connor, Soham Ghoshal, Michael F. Romano, Barry J. Everitt, Paul J. Kenny
Aug 26, 2021
Abstract: Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice...
The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s
Hale Tunbak, Rocio Enriquez-Gasca, Christopher H. C. Tie, Poppy A. Gould, Petra Mlcochova, Ravindra K. Gupta, Liane Fernandes, James Holt, Annemarthe G. van der Veen, Evangelos Giampazolias, Kathleen H. Burns, Pierre V. Maillard, Helen M. Rowe
Oct 18, 2021