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Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans
Michele Perni, Benedetta Mannini, Catherine K. Xu, Janet R. Kumita, Christopher M. Dobson, Fabrizio Chiti, Michele Vendruscolo
Jul 28, 2021
Abstract: Misfolded protein oligomers are increasingly recognized as highly cytotoxic agents in a wide range of human disorders associated with protein aggregation. In this study, we assessed the possible uptake and resulting...
Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice
Daniela de Barros Mucci, Laura C. Kusinski, Phoebe Wilsmore, Elena Loche, Lucas C. Pantaleão, Thomas J. Ashmore, Heather L. Blackmore, Denise S. Fernandez-Twinn, Maria das Graças T. do Carmo, Susan E. Ozanne
Mar 13, 2021
Abstract: Background: In utero exposure to obesity is consistently associated with increased risk of metabolic disease, obesity and cardiovascular dysfunction in later life despite the divergence of birth weight outcomes. The...
CD36 maintains the gastric mucosa and associates with gastric disease.
Miriam Jacome-Sosa, Zhi-Feng Miao, Vivek S Peche, Edward F Morris, Ramkumar Narendran, Kathryn M Pietka, Dmitri Samovski, Hei-Yong G Lo, Terri Pietka, Andrea Varro, Latisha Love-Gregory, James R Goldenring, Ondrej Kuda, Eric R Gamazon, Jason C Mills, Nada A Abumrad
Nov 02, 2021
The gastric epithelium is often exposed to injurious elements and failure of appropriate healing predisposes to ulcers, hemorrhage, and ultimately cancer. We examined the gastric function of CD36, a protein linked to disease and...