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Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status
Paul A Lyons, James E Peters, Federico Alberici, James Liley, Richard M. R. Coulson, William Astle, Chiara Baldini, Francesco Bonatti, Maria C Cid, Heather Elding, Giacomo Emmi, Jörg Epplen, Loïc Guillevin, David R. W. Jayne, Tao Jiang, Iva Gunnarsson, Peter Lamprecht, Stephen Leslie, Mark A. Little, Davide Martorana, Frank Moosig, Thomas Neumann, Sophie Ohlsson, Stefanie Quickert, Giuseppe A. Ramirez, Barbara Rewerska, Georg Schett, Renato A. Sinico, Wojciech Szczeklik, Vladimir Tesar, Damjan Vukcevic, Benjamin Terrier, Richard A Watts, Augusto Vaglio, Julia U Holle, Chris Wallace, Kenneth G. C. Smith, Mohammed Akil, Jonathan Barratt, Neil Basu, Adam S. Butterworth, Ian Bruce, Michael Clarkson, Niall Conlon, Bhaskar DasGupta, Timothy W. R. Doulton, Georgina Espígol-Frigolé, Oliver Flossmann, Armando Gabrielli, Jolanta Gasior, Gina Gregorini, Giuseppe Guida, José Hernández-Rodríguez, Zdenka Hruskova, Amy Hudson, Ann Knight, Peter Lanyon, Raashid Luqmani, Malgorzata Magliano, Angelo A. Manfredi, Christopher Marguerie, Federica Maritati, Chiara Marvisi, Neil J. McHugh, Eamonn Molloy, Allan Motyer, Chetan Mukhtyar, Leonid Padyukov, Alberto Pesci, Sergio Prieto-Gonzalez, Marc Ramentol-Sintas, Petra Reis, Dario Roccatello, Patrizia Rovere-Querini, Carlo Salvarani, Francesca Santarsia, Roser Solans-Laque, Nicole Soranzo, Jo Taylor, Julie Wessels, Jochen Zwerina
Nov 11, 2020
Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we...
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Abstract Multiple psychiatric disorders have been associated with abnormalities in both the innate and adaptive immune systems. The role of these abnormalities in pathogenesis, and whether they...
Mary-Ellen Lynall, Blagoje Soskic, James Hayhurst, Jeremy Schwartzentruber, Daniel F Levey, Gita A Pathak, Renato Polimanti, Joel Gelernter, Murray B Stein, Gosia Trynka, Menna R Clatworthy, Ed Bullmore
Oct 15, 2022
Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians
Yang Luo, Sara Suliman, Samira Asgari, Tiffany Amariuta, Yuriy Baglaenko, Marta Martínez-Bonet, Kazuyoshi Ishigaki, Maria Gutierrez-Arcelus, Roger Calderon, Leonid Lecca, Segundo R. León, Judith Jimenez, Rosa Yataco, Carmen Contreras, Jerome T. Galea, Mercedes Becerra, Sergey Nejentsev, Peter A. Nigrovic, D. Branch Moody, Megan B. Murray, Soumya Raychaudhuri
Aug 20, 2020
Abstract: Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis, 5–15% will develop active tuberculosis (TB). Approximately half will progress to active TB within the first 18 months after infection...