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Results: 22
Genomics of the Argentinian cholera epidemic elucidate the contrasting dynamics of epidemic and endemic Vibrio cholerae
Matthew J. Dorman, Daryl Domman, Tomás Poklepovich, Charlotte Tolley, Gisella Zolezzi, Leanne Kane, María Rosa Viñas, Marcela Panagópulo, Miriam Moroni, Norma Binsztein, María Inés Caffer, Simon Clare, Gordon Dougan, George P. C. Salmond, Julian Parkhill, Josefina Campos, Nicholas R. Thomson
Oct 01, 2020
Increasing incidence of group B streptococcus neonatal infections in the Netherlands is associated with clonal expansion of CC17 and CC23
Dorota Jamrozy, Merijn W. Bijlsma, Marcus C. de Goffau, Diederik van de Beek, Taco W. Kuijpers, Julian Parkhill, Arie van der Ende, Stephen D. Bentley
Jun 12, 2021
Abstract: Group B streptococcus (GBS) is the leading cause of neonatal invasive disease worldwide. In the Netherlands incidence of the disease increased despite implementation of preventive guidelines. We describe a genomic...
Increasing incidence of group B streptococcus neonatal infections in the Netherlands is associated with clonal expansion of CC17 and CC23
Dorota Jamrozy, Merijn W. Bijlsma, Marcus C. de Goffau, Diederik van de Beek, Taco W. Kuijpers, Julian Parkhill, Arie van der Ende, Stephen D. Bentley
Jun 12, 2020
Abstract: Group B streptococcus (GBS) is the leading cause of neonatal invasive disease worldwide. In the Netherlands incidence of the disease increased despite implementation of preventive guidelines. We describe a genomic...
Paratype
Arif M Tanmoy, Yogesh Hooda, Mohammad SI Sajib, Kesia E da Silva, Junaid Iqbal, Farah N Qamar, Stephen P Luby, Gordon Dougan, Zoe A Dyson, Stephen Baker, Denise O Garrett, Jason R Andrews, Samir K Saha, Senjuti Saha
Dec 23, 2022
Salmonella Paratyphi A, the primary etiology of paratyphoid, is estimated to cause 3.4 million infections annually, worldwide. With rising antimicrobial resistance and no licensed vaccines, genomic surveillance is key to track...
Genomics of the Argentinian cholera epidemic elucidate the contrasting dynamics of epidemic and endemic Vibrio cholerae
Matthew J. Dorman, Daryl Domman, Tomás Poklepovich, Charlotte Tolley, Gisella Zolezzi, Leanne Kane, María Rosa Viñas, Marcela Panagópulo, Miriam Moroni, Norma Binsztein, María Inés Caffer, Simon Clare, Gordon Dougan, George P. C. Salmond, Julian Parkhill, Josefina Campos, Nicholas R. Thomson
Oct 01, 2021
Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae
The erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion.
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies
Olivia J. S. Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J. Savill, Svenja Hester, Sophie Ravel, Jack D. Sunter, Camilla Trevor, Steven Rust, Tristan J. Vaughan, Ralph Minter, Shabaz Mohammed, Wendy Gibson, Martin C. Taylor, Matthew K. Higgins, Mark Carrington
Mar 12, 2021
Abstract: Persistent pathogens have evolved to avoid elimination by the mammalian immune system including mechanisms to evade complement. Infections with African trypanosomes can persist for years and cause human and animal...
A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131
Mailis Maes, Zoe A. Dyson, Sarah E. Smith, David A. Goulding, Catherine Ludden, Stephen Baker, Paul Kellam, Stephen T. Reece, Gordon Dougan, Josefin Bartholdson Scott
Aug 02, 2021
A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131
Mailis Maes, Zoe A. Dyson, Sarah E. Smith, David A. Goulding, Catherine Ludden, Stephen Baker, Paul Kellam, Stephen T. Reece, Gordon Dougan, Josefin Bartholdson Scott
Jul 28, 2021
Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection
Nicholas O. Burton, Cristian Riccio, Alexandra Dallaire, Jonathan Price, Benjamin Jenkins, Albert Koulman, Eric A. Miska
Apr 08, 2021
Abstract: Parental exposure to pathogens can prime offspring immunity in diverse organisms. The mechanisms by which this heritable priming occurs are largely unknown. Here we report that the soil bacteria Pseudomonas vranovensis...
Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era
Anna K. Pöntinen, Janetta Top, Sergio Arredondo-Alonso, Gerry Tonkin-Hill, Ana R. Freitas, Carla Novais, Rebecca A. Gladstone, Maiju Pesonen, Rodrigo Meneses, Henri Pesonen, John A. Lees, Dorota Jamrozy, Stephen D. Bentley, Val F. Lanza, Carmen Torres, Luisa Peixe, Teresa M. Coque, Julian Parkhill, Anita C. Schürch, Rob J. L. Willems, Jukka Corander
Mar 09, 2021
Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress
Luiza Mendonça, Andrew Howe, James B. Gilchrist, Yuewen Sheng, Dapeng Sun, Michael L. Knight, Laura C. Zanetti-Domingues, Benji Bateman, Anna-Sophia Krebs, Long Chen, Julika Radecke, Vivian D. Li, Tao Ni, Ilias Kounatidis, Mohamed A. Koronfel, Marta Szynkiewicz, Maria Harkiolaki, Marisa L. Martin-Fernandez, William James, Peijun Zhang
Jul 30, 2021
Abstract: Since the outbreak of the SARS-CoV-2 pandemic, there have been intense structural studies on purified viral components and inactivated viruses. However, structural and ultrastructural evidence on how the SARS-CoV-2...
Isolation and comparative genomics of Mycobacterium tuberculosis isolates from cattle and their attendants in South India
Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions
Gytis Dudas, Samuel L. Hong, Barney I. Potter, Sébastien Calvignac-Spencer, Frédéric S. Niatou-Singa, Thais B. Tombolomako, Terence Fuh-Neba, Ulrich Vickos, Markus Ulrich, Fabian H. Leendertz, Kamran Khan, Carmen Huber, Alexander Watts, Ingrida Olendraitė, Joost Snijder, Kim N. Wijnant, Alexandre M.J.J. Bonvin, Pascale Martres, Sylvie Behillil, Ahidjo Ayouba, Martin Foudi Maidadi, Dowbiss Meta Djomsi, Celestin Godwe, Christelle Butel, Aistis Šimaitis, Miglė Gabrielaitė, Monika Katėnaitė, Rimvydas Norvilas, Ligita Raugaitė, Giscard Wilfried Koyaweda, Jephté Kaleb Kandou, Rimvydas Jonikas, Inga Nasvytienė, Živilė Žemeckienė, Dovydas Gečys, Kamilė Tamušauskaitė, Milda Norkienė, Emilija Vasiliūnaitė, Danguolė Žiogienė, Albertas Timinskas, Marius Šukys, Mantas Šarauskas, Gediminas Alzbutas, Adrienne Amuri Aziza, Eddy Kinganda Lusamaki, Jean-Claude Makangara Cigolo, Francisca Muyembe Mawete, Emmanuel Lokilo Lofiko, Placide Mbala Kingebeni, Jean-Jacques Muyembe Tamfum, Marie Roseline Darnycka Belizaire, René Ghislain Essomba, Marie Claire Okomo Assoumou, Akenji Blaise Mboringong, Alle Baba Dieng, Dovilė Juozapaitė, Salome Hosch, Justino Obama, Mitoha Ondo’o Ayekaba, Daniel Naumovas, Arnoldas Pautienius, Clotaire Donatien Rafaï, Astra Vitkauskienė, Rasa Ugenskienė, Alma Gedvilaitė, Darius Čereškevičius, Vaiva Lesauskaitė, Lukas Žemaitis, Laimonas Griškevičius, Guy Baele
Oct 01, 2021
Abstract: Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2...
A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131
Mailis Maes, Zoe A. Dyson, Sarah E. Smith, David A. Goulding, Catherine Ludden, Stephen Baker, Paul Kellam, Stephen T. Reece, Gordon Dougan, Josefin Bartholdson Scott
Jul 24, 2020
Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes
Maria A. Spyrou, Marcel Keller, Rezeda I. Tukhbatova, Christiana L. Scheib, Elizabeth A. Nelson, Aida Andrades Valtueña, Gunnar U. Neumann, Don Walker, Amelie Alterauge, Niamh Carty, Craig Cessford, Hermann Fetz, Michaël Gourvennec, Robert Hartle, Michael Henderson, Kristin von Heyking, Sarah A. Inskip, Sacha Kacki, Felix M. Key, Elizabeth L. Knox, Christian Later, Prishita Maheshwari-Aplin, Joris Peters, John E. Robb, Jürgen Schreiber, Toomas Kivisild, Dominique Castex, Sandra Lösch, Michaela Harbeck, Alexander Herbig, Kirsten I. Bos, Johannes Krause
Oct 01, 2020
Abstract: The second plague pandemic, caused by Yersinia pestis, devastated Europe and the nearby regions between the 14th and 18th centuries AD. Here we analyse human remains from ten European archaeological sites spanning this...
Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei
Hao Chung The, Christine Boinett, Duy Pham Thanh, Claire Jenkins, Francois-Xavier Weill, Benjamin P. Howden, Mary Valcanis, Niall De Lappe, Martin Cormican, Sonam Wangchuk, Ladaporn Bodhidatta, Carl J. Mason, To Nguyen Thi Nguyen, Tuyen Ha Thanh, Vinh Phat Voong, Vu Thuy Duong, Phu Huong Lan Nguyen, Paul Turner, Ryan Wick, Pieter-Jan Ceyssens, Guy Thwaites, Kathryn E. Holt, Nicholas R. Thomson, Maia A. Rabaa, Stephen Baker
Oct 22, 2020
Abstract: Shigella sonnei increasingly dominates the international epidemiological landscape of shigellosis. Treatment options for S. sonnei are dwindling due to resistance to several key antimicrobials, including the...
Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex
Álvaro Chiner-Oms, Michael Berney, Christine Boinett, Fernando González-Candelas, Douglas B. Young, Sebastien Gagneux, William R. Jacobs, Julian Parkhill, Teresa Cortes, Iñaki Comas
Sep 04, 2020
Abstract: The Mycobacterium tuberculosis complex (MTBC) members display different host-specificities and virulence phenotypes. Here, we have performed a comprehensive RNAseq and methylome analysis of the main clades of the MTBC...
Long-read-sequenced reference genomes of the seven major lineages of enterotoxigenic Escherichia coli (ETEC) circulating in modern time
Astrid von Mentzer, Grace A. Blackwell, Derek Pickard, Christine J. Boinett, Enrique Joffré, Andrew J. Page, Ann-Mari Svennerholm, Gordon Dougan, Åsa Sjöling
Apr 29, 2021
Abstract: Enterotoxigenic Escherichia coli (ETEC) is an enteric pathogen responsible for the majority of diarrheal cases worldwide. ETEC infections are estimated to cause 80,000 deaths annually, with the highest rates of burden...
A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131
Mailis Maes, Zoe A. Dyson, Sarah E. Smith, David A. Goulding, Catherine Ludden, Stephen Baker, Paul Kellam, Stephen T. Reece, Gordon Dougan, Josefin Bartholdson Scott
Mar 26, 2021