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PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1
Rimma Belotserkovskaya, Elisenda Raga Gil, Nicola Lawrence, Richard Butler, Gillian Clifford, Marcus D. Wilson, Stephen P. Jackson
Feb 09, 2021
Abstract: Loss of functional BRCA1 protein leads to defects in DNA double-strand break (DSB) repair by homologous recombination (HR) and renders cells hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibitors used to...
Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests.
Titia G Meijer, Luan Nguyen, Arne Van Hoeck, Anieta M Sieuwerts, Nicole S Verkaik, Marjolijn M Ladan, Kirsten Ruigrok-Ritstier, Carolien HM van Deurzen, Harmen JG van de Werken, Esther H Lips, Sabine C Linn, Yasin Memari, Helen Davies, Serena Nik-Zainal, Roland Kanaar, John WM Martens, Edwin Cuppen, Agnes Jager, Dik C van Gent
Jun 29, 2022
Germline BRCA1/2 mutation status is predictive for response to Poly-[ADP-Ribose]-Polymerase (PARP) inhibitors in breast cancer (BC) patients. However, non-germline BRCA1/2 mutated and homologous recombination repair deficient...