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TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis
Oct 02, 2020
Abstract: The HUSH complex represses retroviruses, transposons and genes to maintain the integrity of vertebrate genomes. HUSH regulates deposition of the epigenetic mark H3K9me3, but how its three core subunits — TASOR, MPP8...
Tgf-β1 transcriptionally promotes 90K expression
Antonino Grassadonia, Vincenzo Graziano, Sara Pagotto, Angelo Veronese, Cesidio Giuliani, Marco Marchisio, Paola Lanuti, Michele De Tursi, Maurizia D’Egidio, Pietro De Marino, Davide Brocco, Patrizia Vici, Laura De Lellis, Alessandro Cama, Clara Natoli, Nicola Tinari
Apr 22, 2021
Abstract: The 90K protein, also known as Mac-2 BP or LGALS3BP, can activate the immune response in part by increasing major histocompatibility (MHC) class I levels. In studies on a non-immune cell model, the rat FRTL-5 cell...
Tgf-β1 transcriptionally promotes 90K expression
Antonino Grassadonia, Vincenzo Graziano, Sara Pagotto, Angelo Veronese, Cesidio Giuliani, Marco Marchisio, Paola Lanuti, Michele De Tursi, Maurizia D’Egidio, Pietro Di Marino, Davide Brocco, Patrizia Vici, Laura De Lellis, Alessandro Cama, Clara Natoli, Nicola Tinari
May 11, 2021
Abstract: The 90K protein, also known as Mac-2 BP or LGALS3BP, can activate the immune response in part by increasing major histocompatibility (MHC) class I levels. In studies on a non-immune cell model, the rat FRTL-5 cell...
A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification.
B Edginton-White, A Maytum, SG Kellaway, DK Goode, P Keane, I Pagnuco, SA Assi, L Ames, M Clarke, PN Cockerill, B Göttgens, JB Cazier, C Bonifer
Jan 19, 2023
Developmental control of gene expression critically depends on distal cis-regulatory elements including enhancers which interact with promoters to activate gene expression. To date no global experiments have been conducted that...
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis
Oct 02, 2021
Abstract: The HUSH complex represses retroviruses, transposons and genes to maintain the integrity of vertebrate genomes. HUSH regulates deposition of the epigenetic mark H3K9me3, but how its three core subunits — TASOR, MPP8...
Tgf-β1 transcriptionally promotes 90K expression
Antonino Grassadonia, Vincenzo Graziano, Sara Pagotto, Angelo Veronese, Cesidio Giuliani, Marco Marchisio, Paola Lanuti, Michele De Tursi, Maurizia D’Egidio, Pietro Di Marino, Davide Brocco, Patrizia Vici, Laura De Lellis, Alessandro Cama, Clara Natoli, Nicola Tinari
May 12, 2021
Abstract: The 90K protein, also known as Mac-2 BP or LGALS3BP, can activate the immune response in part by increasing major histocompatibility (MHC) class I levels. In studies on a non-immune cell model, the rat FRTL-5 cell...