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A CD8 + NK cell transcriptomic signature associated with clinical outcome in relapsing remitting multiple sclerosis
Eoin F. McKinney, Iona Cuthbertson, Kristina M. Harris, Dawn E. Smilek, Christopher Connor, Giulia Manferrari, Edward J. Carr, Scott S. Zamvil, Kenneth G. C. Smith
Jan 27, 2021
Abstract: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) with the majority of cases characterised by relapsing/remitting (RRMS) attacks of neurologic dysfunction followed by...
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Abstract Multiple psychiatric disorders have been associated with abnormalities in both the innate and adaptive immune systems. The role of these abnormalities in pathogenesis, and whether they...
Mary-Ellen Lynall, Blagoje Soskic, James Hayhurst, Jeremy Schwartzentruber, Daniel F Levey, Gita A Pathak, Renato Polimanti, Joel Gelernter, Murray B Stein, Gosia Trynka, Menna R Clatworthy, Ed Bullmore
Oct 15, 2022