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Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms
Richard M. Salmon, Jingxu Guo, Jennifer H. Wood, Zhen Tong, John S. Beech, Aleksandra Lawera, Minmin Yu, David J. Grainger, Jill Reckless, Nicholas W. Morrell, Wei Li
Apr 01, 2021
Abstract: Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. However...
Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10.
Jingxu Guo, Bin Liu, Midory Thorikay, Minmin Yu, Xiaoyan Li, Zhen Tong, Richard M Salmon, Randy Read, Peter Ten Dijke, Nicholas Morrell, Wei Li
May 09, 2022
Heterozygous mutations in BMPR2 (bone morphogenetic protein (BMP) receptor type II) cause pulmonary arterial hypertension. BMPRII is a receptor for over 15 BMP ligands, but why BMPR2 mutations cause lung-specific pathology is...