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Results: 11
The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis
LFL Wilson, T Dendooven, SW Hardwick, A Echevarría-Poza, T Tryfona, KBRM Krogh, Dima Chirgadze, Ben Luisi, DT Logan, K Mani, P Dupree
Jun 09, 2022
Structure of inhibitor-bound mammalian complex I
Hannah R. Bridges, Justin G. Fedor, James N. Blaza, Andrea Di Luca, Alexander Jussupow, Owen D. Jarman, John J. Wright, Ahmed-Noor A. Agip, Ana P. Gamiz-Hernandez, Maxie M. Roessler, Ville R. I. Kaila, Judy Hirst
Oct 18, 2021
Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD
Luke A. Perera, Steffen Preissler, Nathan R. Zaccai, Sylvain Prévost, Juliette M. Devos, Michael Haertlein, David Ron
Aug 18, 2021
Abstract: The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a reversible inactivating post-translational modification. Both BiP AMPylation and deAMPylation are catalysed by a single ER-localised...
Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates
Leo Kiss, Tyler Rhinesmith, Jakub Luptak, Claire F Dickson, Jonas Weidenhausen, Shannon Smyly, Ji-Chun Yang, Sarah L Maslen, Irmgard Sinning, David Neuhaus, Dean Clift, Leo C James
Apr 15, 2023
Higher-order phosphatase–substrate contacts terminate the integrated stress response
Abstract: Many regulatory PPP1R subunits join few catalytic PP1c subunits to mediate phosphoserine and phosphothreonine dephosphorylation in metazoans. Regulatory subunits engage the surface of PP1c, locally affecting flexible...
Structure of inhibitor-bound mammalian complex I
Hannah R. Bridges, Justin G. Fedor, James N. Blaza, Andrea Di Luca, Alexander Jussupow, Owen D. Jarman, John J. Wright, Ahmed-Noor A. Agip, Ana P. Gamiz-Hernandez, Maxie M. Roessler, Ville R. I. Kaila, Judy Hirst
Oct 16, 2020
The receptor PTPRU is a redox sensitive pseudophosphatase
Iain M. Hay, Gareth W. Fearnley, Pablo Rios, Maja Köhn, Hayley J. Sharpe, Janet E. Deane
Jun 26, 2020
Abstract: The receptor-linked protein tyrosine phosphatases (RPTPs) are key regulators of cell-cell communication through the control of cellular phosphotyrosine levels. Most human RPTPs possess an extracellular receptor domain...
The receptor PTPRU is a redox sensitive pseudophosphatase
Iain M. Hay, Gareth W. Fearnley, Pablo Rios, Maja Köhn, Hayley J. Sharpe, Janet E. Deane
Jun 26, 2021
Abstract: The receptor-linked protein tyrosine phosphatases (RPTPs) are key regulators of cell-cell communication through the control of cellular phosphotyrosine levels. Most human RPTPs possess an extracellular receptor domain...