Search

Results: 6

Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells.

Yu Wei Zhang, Julian Mess, Nadim Aizarani, Pankaj Mishra, Carys Johnson, Mari Carmen Romero-Mulero, Jasmin Rettkowski, Katharina Schönberger, Nadine Obier, Karin Jäcklein, Nadine M Woessner, Maria-Eleni Lalioti, Talia Velasco-Hernandez, Katarzyna Sikora, Ralph Wäsch, Bernhard Lehnertz, Guy Sauvageau, Thomas Manke, Pablo Menendez, Sebastian Gottfried Walter, Susana Minguet, Elisa Laurenti, Stefan Günther, Dominic Grün, Nina Cabezas-Wallscheid

Jul 14, 2022

Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic hierarchy is occupied by dormant HSCs...

article /631/532/1542 /631/532/2443 /13/31 /13/100 /64/60 article

Published by:

View Article

Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages

Belén Prados, Raquel Del Toro, Donal MacGrogan, Paula Gómez-Apiñániz, Tania Papoutsi, Pura Muñoz-Cánoves, Simón Méndez-Ferrer, José Luis de la Pompa

Jul 28, 2021

Abstract: Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which...

article /631/80/304 /631/136/815/817 /631/532/1542 /13/31 /13/51 /59/78 /64/60 /96/106 article

Published by:

View Article

A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification.

B Edginton-White, A Maytum, SG Kellaway, DK Goode, P Keane, I Pagnuco, SA Assi, L Ames, M Clarke, PN Cockerill, B Göttgens, JB Cazier, C Bonifer

Jan 19, 2023

Developmental control of gene expression critically depends on distal cis-regulatory elements including enhancers which interact with promoters to activate gene expression. To date no global experiments have been conducted that...