Probing the dynamic stalk region of the ribosome using solution NMR
Xiaolin Wang,
John P. Kirkpatrick,
Hélène M. M. Launay,
Alfonso De Simone,
Daniel Häussinger,
Christopher M. Dobson,
Michele Vendruscolo,
Lisa D. Cabrita,
Christopher A. Waudby,
John Christodoulou
Sep 18, 2020
Abstract: We describe an NMR approach based on the measurement of residual dipolar couplings (RDCs) to probe the structural and motional properties of the dynamic regions of the ribosome. Alignment of intact 70S ribosomes in...