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Results: 11
Single-cell sequencing of genomic DNA resolves sub-clonal heterogeneity in a melanoma cell line
Enrique I. Velazquez-Villarreal, Shamoni Maheshwari, Jon Sorenson, Ian T. Fiddes, Vijay Kumar, Yifeng Yin, Michelle G. Webb, Claudia Catalanotti, Mira Grigorova, Paul A. Edwards, John D. Carpten, David W. Craig
Feb 17, 2021
Abstract: We performed shallow single-cell sequencing of genomic DNA across 1475 cells from a cell-line, COLO829, to resolve overall complexity and clonality. This melanoma tumor-line has been previously characterized by...
Genetic modification of primary human B cells to model high-grade lymphoma
Rebecca Caeser, Miriam Di Re, Joanna A. Krupka, Jie Gao, Maribel Lara-Chica, João M. L. Dias, Susanna L. Cooke, Rachel Fenner, Zelvera Usheva, Hendrik F. P. Runge, Philip A. Beer, Hesham Eldaly, Hyo-Kyung Pak, Chan-Sik Park, George S. Vassiliou, Brian J. P. Huntly, Annalisa Mupo, Rachael J. M. Bashford-Rogers, Daniel J. Hodson
Oct 03, 2020
Abstract: Sequencing studies of diffuse large B cell lymphoma (DLBCL) have identified hundreds of recurrently altered genes. However, it remains largely unknown whether and how these mutations may contribute to lymphomagenesis...
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response
Dimitra Georgopoulou, Maurizio Callari, Oscar M. Rueda, Abigail Shea, Alistair Martin, Agnese Giovannetti, Fatime Qosaj, Ali Dariush, Suet-Feung Chin, Larissa S. Carnevalli, Elena Provenzano, Wendy Greenwood, Giulia Lerda, Elham Esmaeilishirazifard, Martin O’Reilly, Violeta Serra, Dario Bressan, Gordon B. Mills, H. Raza Ali, Sabina S. Cosulich, Gregory J. Hannon, Alejandra Bruna, Carlos Caldas, H. R. Ali, M. Al Sa’d, S. Alon, S. Aparicio, G. Battistoni, S. Balasubramanian, R. Becker, B. Bodenmiller, E. S. Boyden, D. Bressan, A. Bruna, Marcel Burger, C. Caldas, M. Callari, I. G. Cannell, H. Casbolt, N. Chornay, Y. Cui, A. Dariush, K. Dinh, A. Emenari, Y. Eyal-Lubling, J. Fan, A. Fatemi, E. Fisher, E. A. González-Solares, C. González-Fernández, D. Goodwin, W. Greenwood, F. Grimaldi, G. J. Hannon, O. Harris, S. Harris, C. Jauset, J. A. Joyce, E. D. Karagiannis, T. Kovačević, L. Kuett, R. Kunes, Yoldaş A. Küpcü, D. Lai, E. Laks, H. Lee, M. Lee, G. Lerda, Y. Li, A. McPherson, N. Millar, C. M. Mulvey, F. Nugent, C. H. O’Flanagan, M. Paez-Ribes, I. Pearsall, F. Qosaj, A. J. Roth, O. M. Rueda, T. Ruiz, K. Sawicka, L. A. Sepúlveda, S. P. Shah, A. Shea, A. Sinha, A. Smith, S. Tavaré, S. Tietscher, I. Vázquez-García, S. L. Vogl, N. A. Walton, A. T. Wassie, S. S. Watson, J. Weselak, S. A. Wild, E. Williams, J. Windhager, T. Whitmarsh, C. Xia, P. Zheng, X. Zhuang
Mar 31, 2021
Single-cell sequencing of genomic DNA resolves sub-clonal heterogeneity in a melanoma cell line
Enrique I. Velazquez-Villarreal, Shamoni Maheshwari, Jon Sorenson, Ian T. Fiddes, Vijay Kumar, Yifeng Yin, Michelle G. Webb, Claudia Catalanotti, Mira Grigorova, Paul A. Edwards, John D. Carpten, David W. Craig
Jun 25, 2020
Abstract: We performed shallow single-cell sequencing of genomic DNA across 1475 cells from a cell-line, COLO829, to resolve overall complexity and clonality. This melanoma tumor-line has been previously characterized by...
Genetic modification of primary human B cells to model high-grade lymphoma
Rebecca Caeser, Miriam Di Re, Joanna A. Krupka, Jie Gao, Maribel Lara-Chica, João M. L. Dias, Susanna L. Cooke, Rachel Fenner, Zelvera Usheva, Hendrik F. P. Runge, Philip A. Beer, Hesham Eldaly, Hyo-Kyung Pak, Chan-Sik Park, George S. Vassiliou, Brian J. P. Huntly, Annalisa Mupo, Rachael J. M. Bashford-Rogers, Daniel J. Hodson
Apr 07, 2021
Abstract: Sequencing studies of diffuse large B cell lymphoma (DLBCL) have identified hundreds of recurrently altered genes. However, it remains largely unknown whether and how these mutations may contribute to lymphomagenesis...
Robustness of radiomic features in CT images with different slice thickness, comparing liver tumour and muscle
Lorena Escudero Sanchez, Leonardo Rundo, Andrew B. Gill, Matthew Hoare, Eva Mendes Serrao, Evis Sala
Apr 15, 2021
Abstract: Radiomic image features are becoming a promising non-invasive method to obtain quantitative measurements for tumour classification and therapy response assessment in oncological research. However, despite its...
Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
Roy Rabbie, Naser Ansari-Pour, Oliver Cast, Doreen Lau, Francis Scott, Sarah J. Welsh, Christine Parkinson, Leila Khoja, Luiza Moore, Mark Tullett, Kim Wong, Ingrid Ferreira, Julia M. Martínez Gómez, Mitchell Levesque, Ferdia A. Gallagher, Alejandro Jiménez-Sánchez, Laura Riva, Martin L. Miller, Kieren Allinson, Peter J. Campbell, Pippa Corrie, David C. Wedge, David J. Adams
Aug 27, 2020
Abstract: Metastatic melanoma carries a poor prognosis despite modern systemic therapies. Understanding the evolution of the disease could help inform patient management. Through whole-genome sequencing of 13 melanoma metastases...
Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
Roy Rabbie, Naser Ansari-Pour, Oliver Cast, Doreen Lau, Francis Scott, Sarah J. Welsh, Christine Parkinson, Leila Khoja, Luiza Moore, Mark Tullett, Kim Wong, Ingrid Ferreira, Julia M. Martínez Gómez, Mitchell Levesque, Ferdia A. Gallagher, Alejandro Jiménez-Sánchez, Laura Riva, Martin L. Miller, Kieren Allinson, Peter J. Campbell, Pippa Corrie, David C. Wedge, David J. Adams
Aug 27, 2021
Abstract: Metastatic melanoma carries a poor prognosis despite modern systemic therapies. Understanding the evolution of the disease could help inform patient management. Through whole-genome sequencing of 13 melanoma metastases...
Clonal diversification and histogenesis of malignant germ cell tumours
Thomas RW Oliver, Lia Chappell, Rashesh Sanghvi, Lauren Deighton, Naser Ansari-Pour, Stefan C Dentro, Matthew D Young, Tim HH Coorens, Hyunchul Jung, Tim Butler, Matthew DC Neville, Daniel Leongamornlert, Mathijs A Sanders, Yvette Hooks, Alex Cagan, Thomas J Mitchell, Isidro Cortes-Ciriano, Anne Y Warren, David C Wedge, Rakesh Heer, Nicholas Coleman, Matthew J Murray, Peter J Campbell, Raheleh Rahbari, Sam Behjati
Aug 11, 2022
article /631/67/1679 /631/114/739 /631/1647/514 /631/67/69 /631/67/2329 /45/23 /45/91 /45/70 /13/51 /14/63 article
Published by: Nature Publishing Group UK
Chromosomal copy number heterogeneity predicts survival rates across cancers
Erik van Dijk, Tom van den Bosch, Kristiaan J. Lenos, Khalid El Makrini, Lisanne E. Nijman, Hendrik F. B. van Essen, Nico Lansu, Michiel Boekhout, Joris H. Hageman, Rebecca C. Fitzgerald, Cornelis J. A. Punt, Jurriaan B. Tuynman, Hugo J. G. Snippert, Geert J. P. L. Kops, Jan Paul Medema, Bauke Ylstra, Louis Vermeulen, Daniël M. Miedema
May 27, 2021
Single-cell sequencing of genomic DNA resolves sub-clonal heterogeneity in a melanoma cell line
Enrique I. Velazquez-Villarreal, Shamoni Maheshwari, Jon Sorenson, Ian T. Fiddes, Vijay Kumar, Yifeng Yin, Michelle G. Webb, Claudia Catalanotti, Mira Grigorova, Paul A. Edwards, John D. Carpten, David W. Craig
Jun 25, 2021
Abstract: We performed shallow single-cell sequencing of genomic DNA across 1475 cells from a cell-line, COLO829, to resolve overall complexity and clonality. This melanoma tumor-line has been previously characterized by...