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Results: 7
Live-cell imaging reveals the spatiotemporal organization of endogenous RNA polymerase II phosphorylation at a single gene
Linda S. Forero-Quintero, William Raymond, Tetsuya Handa, Matthew N. Saxton, Tatsuya Morisaki, Hiroshi Kimura, Edouard Bertrand, Brian Munsky, Timothy J. Stasevich
May 26, 2021
Abstract: The carboxyl-terminal domain of RNA polymerase II (RNAP2) is phosphorylated during transcription in eukaryotic cells. While residue-specific phosphorylation has been mapped with exquisite spatial resolution along the...
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells
Cesar L. Cuevas-Velazquez, Tamara Vellosillo, Karina Guadalupe, Hermann Broder Schmidt, Feng Yu, David Moses, Jennifer A. N. Brophy, Dante Cosio-Acosta, Alakananda Das, Lingxin Wang, Alexander M. Jones, Alejandra A. Covarrubias, Shahar Sukenik, José R. Dinneny
Sep 14, 2021
PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1
Rimma Belotserkovskaya, Elisenda Raga Gil, Nicola Lawrence, Richard Butler, Gillian Clifford, Marcus D. Wilson, Stephen P. Jackson
Feb 09, 2021
Abstract: Loss of functional BRCA1 protein leads to defects in DNA double-strand break (DSB) repair by homologous recombination (HR) and renders cells hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibitors used to...
A quantum-inspired classifier for clonogenic assay evaluations
Giuseppe Sergioli, Carmelo Militello, Leonardo Rundo, Luigi Minafra, Filippo Torrisi, Giorgio Russo, Keng Loon Chow, Roberto Giuntini
Feb 02, 2021
Abstract: Recent advances in Quantum Machine Learning (QML) have provided benefits to several computational processes, drastically reducing the time complexity. Another approach of combining quantum information theory with...
A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding
Jerome Jatzlau, Wiktor Burdzinski, Michael Trumpp, Leon Obendorf, Kilian Roßmann, Katharina Ravn, Marko Hyvönen, Francesca Bottanelli, Johannes Broichhagen, Petra Knaus
Jan 25, 2023
Published by: Nature Publishing Group UK
Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses
Jonathan X Meng, Yu Zhang, Dominik Saman, Arshad M Haider, Suman De, Jason C Sang, Karen Brown, Kun Jiang, Jane Humphrey, Linda Julian, Eric Hidari, Steven F Lee, Gabriel Balmus, R Andres Floto, Clare Bryant, Justin LP Benesch, Yu Ye, David Klenerman
May 16, 2022