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Amino acid dependent formaldehyde metabolism in mammals.
Matthias Pietzke, Guillermo Burgos-Barragan, Niek Wit, Jacqueline Tait-Mulder, David Sumpton, Gillian M Mackay, Ketan J Patel, Alexei Vazquez
Jun 17, 2021
Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways starting...
Amino acid dependent formaldehyde metabolism in mammals
Matthias Pietzke, Guillermo Burgos-Barragan, Niek Wit, Jacqueline Tait-Mulder, David Sumpton, Gillian M. Mackay, Ketan J. Patel, Alexei Vazquez
Feb 18, 2021
Abstract: Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways...
Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized 13 C magnetic resonance
Emine Can, Mor Mishkovsky, Hikari A. I. Yoshihara, Nicolas Kunz, Dominique-Laurent Couturier, Ulf Petrausch, Marie-Agnès Doucey, Arnaud Comment
Jan 12, 2021
Abstract: The metabolic shift induced in human CD4+ T lymphocytes by stimulation is characterized by an upregulation of glycolysis, leading to an augmentation in lactate production. This adaptation has already been highlighted...
Amino acid dependent formaldehyde metabolism in mammals
Matthias Pietzke, Guillermo Burgos-Barragan, Niek Wit, Jacqueline Tait-Mulder, David Sumpton, Gillian M. Mackay, Ketan J. Patel, Alexei Vazquez
Jun 16, 2020
Abstract: Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways...