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Results: 7
Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms
Richard M. Salmon, Jingxu Guo, Jennifer H. Wood, Zhen Tong, John S. Beech, Aleksandra Lawera, Minmin Yu, David J. Grainger, Jill Reckless, Nicholas W. Morrell, Wei Li
Apr 01, 2021
Abstract: Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. However...
Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29
Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies
Olivia J. S. Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J. Savill, Svenja Hester, Sophie Ravel, Jack D. Sunter, Camilla Trevor, Steven Rust, Tristan J. Vaughan, Ralph Minter, Shabaz Mohammed, Wendy Gibson, Martin C. Taylor, Matthew K. Higgins, Mark Carrington
Mar 12, 2021
Abstract: Persistent pathogens have evolved to avoid elimination by the mammalian immune system including mechanisms to evade complement. Infections with African trypanosomes can persist for years and cause human and animal...
Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10.
Jingxu Guo, Bin Liu, Midory Thorikay, Minmin Yu, Xiaoyan Li, Zhen Tong, Richard M Salmon, Randy Read, Peter Ten Dijke, Nicholas Morrell, Wei Li
May 09, 2022
Heterozygous mutations in BMPR2 (bone morphogenetic protein (BMP) receptor type II) cause pulmonary arterial hypertension. BMPRII is a receptor for over 15 BMP ligands, but why BMPR2 mutations cause lung-specific pathology is...
Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti.
Yoann Saucereau, Thomas H Wilson, Matthew CK Tang, Martin C Moncrieffe, Steven W Hardwick, Dimitri Y Chirgadze, Sandro G Soares, Maria Jose Marcaida, Nicholas J Gay, Monique Gangloff
Sep 02, 2022
Aedes aegypti has evolved to become an efficient vector for arboviruses but the mechanisms of host-pathogen tolerance are unknown. Immunoreceptor Toll and its ligand Spaetzle have undergone duplication which may allow...
A Bone Morphogenetic Protein (BMP)-derived Peptide Based on the Type I Receptor-binding Site Modifies Cell-type Dependent BMP Signalling
Abstract: Bone morphogenetic proteins (BMPs) are multifunctional cytokines of the transforming growth factor β (TGFβ) superfamily with potential therapeutic applications due to their broad biological functionality. Designing BMP...