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Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms
Richard M. Salmon, Jingxu Guo, Jennifer H. Wood, Zhen Tong, John S. Beech, Aleksandra Lawera, Minmin Yu, David J. Grainger, Jill Reckless, Nicholas W. Morrell, Wei Li
Apr 01, 2021
Abstract: Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. However...
Acute and chronic hypoxia differentially predispose lungs for metastases
Moritz Reiterer, Renato Colaço, Pardis Emrouznejad, Anders Jensen, Helene Rundqvist, Randall S. Johnson, Cristina Branco
Jul 14, 2020
Abstract: Oscillations in oxygen levels affect malignant cell growth, survival, and metastasis, but also somatic cell behaviour. In this work, we studied the effect of the differential expression of the two primary hypoxia...
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
Pooja Sharma, Robert Mahen, Maxim Rossmann, Jamie E. Stokes, Bryn Hardwick, David J. Huggins, Amy Emery, Dominique L. Kunciw, Marko Hyvönen, David R. Spring, Grahame J. McKenzie, Ashok R. Venkitaraman
Nov 03, 2020
Abstract: The human polo-like kinase PLK1 coordinates mitotic chromosome segregation by phosphorylating multiple chromatin- and kinetochore-binding proteins. How PLK1 activity is directed to specific substrates via...
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
Lisa Mayr, Felix Grabherr, Julian Schwärzler, Isabelle Reitmeier, Felix Sommer, Thomas Gehmacher, Lukas Niederreiter, Gui-Wei He, Barbara Ruder, Kai T. R. Kunz, Piotr Tymoszuk, Richard Hilbe, David Haschka, Clemens Feistritzer, Romana R. Gerner, Barbara Enrich, Nicole Przysiecki, Markus Seifert, Markus A. Keller, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Ivan Tancevski, Heinz Zoller, Alexander R. Moschen, Günter Weiss, Christoph Becker, Philip Rosenstiel, Arthur Kaser, Herbert Tilg, Timon E. Adolph
Apr 14, 2021
Abstract: The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by...
Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution
Abstract Germ-line hypomorphism of the pleiotropic transcription factor Myc in mice, either through Myc gene haploinsufficiency or deletion of...
Nicole M Sodir, Luca Pellegrinet, Roderik M Kortlever, Tania Campos, Yong-won Kwon, Shinseog Kim, Daniel Garcia, Alessandra Perfetto, Panayiotis Anastasiou, Lamorna Brown Swigart, Mark J Arends, Trevor D Littlewood, Gerard I Evan
Nov 14, 2022
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis
C. S. Gallagher, N. Mäkinen, H. R. Harris, N. Rahmioglu, O. Uimari, J. P. Cook, N. Shigesi, T. Ferreira, D. R. Velez-Edwards, T. L. Edwards, S. Mortlock, Z. Ruhioglu, F. Day, C. M. Becker, V. Karhunen, H. Martikainen, M.-R. Järvelin, R. M. Cantor, P. M. Ridker, K. L. Terry, J. E. Buring, S. D. Gordon, S. E. Medland, G. W. Montgomery, D. R. Nyholt, D. A. Hinds, J. Y. Tung, J. R. B. Perry, P. A. Lind, J. N. Painter, N. G. Martin, A. P. Morris, D. I. Chasman, S. A. Missmer, K. T. Zondervan, C. C. Morton, Michelle Agee, Babak Alipanahi, Adam Auton, Robert K. Bell, Katarzyna Bryc, Sarah L. Elson, Pierre Fontanillas, Nicholas A. Furlotte, Karen E. Huber, Aaron Kleinman, Nadia K. Litterman, Matthew H. McIntyre, Joanna L. Mountain, Elizabeth S. Noblin, Carrie A. M. Northover, Steven J. Pitts, J. Fah Sathirapongsasuti, Olga V. Sazonova, Janie F. Shelton, Suyash Shringarpure, Chao Tian, Vladimir Vacic, Catherine H. Wilson
Oct 23, 2020
Abstract: Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS...
Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer.
Nikita Sushentsev, Mary McLean, Anne Warren, Arnold JV Benjamin, Cara Brodie, Amy Frary, Andrew Gill, Julia Jones, Joshua Kaggie, Benjamin W Lamb, Matthew J Locke, Jodi Miller, Ian G Mills, Andrew N Priest, Fraser JL Robb, Nimish Shah, Rolf S Schulte, Martin Graves, Vincent Gnanapragasam, Kevin Brindle, Tristan Barrett, Ferdia Gallagher
Mar 07, 2022
Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene.
Katherine A Kentistou, Jian'an Luan, Laura BL Wittemans, Catherine Hambly, Lucija Klaric, Zoltán Kutalik, John R Speakman, Nicholas J Wareham, Timothy J Kendall, Claudia Langenberg, James F Wilson, Peter K Joshi, Nicholas M Morton
Jan 19, 2023
Obesity remains an unmet global health burden. Detrimental anatomical distribution of body fat is a major driver of obesity-mediated mortality risk and is demonstrably heritable. However, our understanding of the full genetic...
Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer.
Nikita Sushentsev, Mary McLean, Anne Warren, Arnold JV Benjamin, Cara Brodie, Amy Frary, Andrew Gill, Julia Jones, Joshua Kaggie, Benjamin W Lamb, Matthew J Locke, Jodi Miller, Ian G Mills, Andrew N Priest, Fraser JL Robb, Nimish Shah, Rolf S Schulte, Martin Graves, Vincent Gnanapragasam, Kevin Brindle, Tristan Barrett, Ferdia Gallagher
Jan 28, 2022
Cancer associated fibroblast FAK regulates malignant cell metabolism
Fevzi Demircioglu, Jun Wang, Juliana Candido, Ana S. H. Costa, Pedro Casado, Beatriz de Luxan Delgado, Louise E. Reynolds, Jesus Gomez-Escudero, Emma Newport, Vinothini Rajeeve, Ann-Marie Baker, Marina Roy-Luzarraga, Trevor A. Graham, Julie Foster, Yu Wang, James J. Campbell, Rajinder Singh, Penglie Zhang, Thomas J. Schall, Frances R. Balkwill, Jane Sosabowski, Pedro R. Cutillas, Christian Frezza, Patricia Sancho, Kairbaan Hodivala-Dilke
Mar 10, 2021
Abstract: Emerging evidence suggests that cancer cell metabolism can be regulated by cancer-associated fibroblasts (CAFs), but the mechanisms are poorly defined. Here we show that CAFs regulate malignant cell metabolism through...
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine
Ida M. Modvig, Daniel B. Andersen, Kaare V. Grunddal, Rune E. Kuhre, Christoffer Martinussen, Charlotte B. Christiansen, Cathrine Ørskov, Pierre Larraufie, Richard G. Kay, Frank Reimann, Fiona M. Gribble, Bolette Hartmann, Kirstine N. Bojsen-Møller, Sten Madsbad, Nicolai J. Wewer Albrechtsen, Jens J. Holst
Feb 02, 2021
Abstract: Objectives: Gastrointestinal hormones contribute to the beneficial effects of Roux-en-Y gastric bypass surgery (RYGB) on glycemic control. Secretin is secreted from duodenal S cells in response to low luminal pH, but...
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
Nour Ghaddar, Shuo Wang, Bethany Woodvine, Jothilatha Krishnamoorthy, Vincent van Hoef, Cedric Darini, Urszula Kazimierczak, Nicolas Ah-son, Helmuth Popper, Myriam Johnson, Leah Officer, Ana Teodósio, Massimo Broggini, Koren K. Mann, Maria Hatzoglou, Ivan Topisirovic, Ola Larsson, John Le Quesne, Antonis E. Koromilas
Jul 30, 2021
Abstract: The integrated stress response (ISR) is an essential stress-support pathway increasingly recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung adenocarcinoma (LUAD) development...
The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
Ricky M. Trigg, Liam C. Lee, Nina Prokoph, Leila Jahangiri, C. Patrick Reynolds, G. A. Amos Burke, Nicola A. Probst, Miaojun Han, Jamie D. Matthews, Hong Kai Lim, Eleanor Manners, Sonia Martinez, Joaquin Pastor, Carmen Blanco-Aparicio, Olaf Merkel, Ines Garces de Los Fayos Alonso, Petra Kodajova, Simone Tangermann, Sandra Högler, Ji Luo, Lukas Kenner, Suzanne D. Turner
Nov 27, 2020
Abstract: Resistance to anaplastic lymphoma kinase (ALK)-targeted therapy in ALK-positive non-small cell lung cancer has been reported, with the majority of acquired resistance mechanisms relying on bypass signaling. To...
article /631/67/70 /631/67/1059/2326 /631/67/1059/602 /631/67/2332 /13/1 /13/2 /13/31 /13/51 /13/89 /13/95 /13/106 /13/109 /38/1 /38/22 /38/23 /38/77 /38/89 /38/90 /38/109 /42/47 /42/89 /45/22 /45/23 /45/41 /45/47 /45/77 /49/22 /49/23 /64/60 /64/110 /82/1 /82/29 /82/51 /96/1 /96/2 /96/31 /96/95 /96/106 article
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Anna Whitehead, Fynn N. Krause, Amy Moran, Amanda D. V. MacCannell, Jason L. Scragg, Ben D. McNally, Edward Boateng, Steven A. Murfitt, Samuel Virtue, John Wright, Jack Garnham, Graeme R. Davies, James Dodgson, Jurgen E. Schneider, Andrew J. Murray, Christopher Church, Antonio Vidal-Puig, Klaus K. Witte, Julian L. Griffin, Lee D. Roberts
Mar 26, 2021
Abstract: Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an...
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Sep 22, 2021
Abstract: Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL....
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine
Ida M. Modvig, Daniel B. Andersen, Kaare V. Grunddal, Rune E. Kuhre, Christoffer Martinussen, Charlotte B. Christiansen, Cathrine Ørskov, Pierre Larraufie, Richard G. Kay, Frank Reimann, Fiona M. Gribble, Bolette Hartmann, Kirstine N. Bojsen-Møller, Sten Madsbad, Nicolai J. Wewer Albrechtsen, Jens J. Holst
Aug 24, 2020
Abstract: Objectives: Gastrointestinal hormones contribute to the beneficial effects of Roux-en-Y gastric bypass surgery (RYGB) on glycemic control. Secretin is secreted from duodenal S cells in response to low luminal pH, but...
Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos
Abstract: In all metazoans, a small number of evolutionarily conserved signaling pathways are reiteratively used during development to orchestrate critical patterning and morphogenetic processes. Among these, Notch (N) signaling...
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
Clément Bodineau, Mercedes Tomé, Sarah Courtois, Ana S. H. Costa, Marco Sciacovelli, Benoit Rousseau, Elodie Richard, Pierre Vacher, Carlos Parejo-Pérez, Emilie Bessede, Christine Varon, Pierre Soubeyran, Christian Frezza, Piedad Del Socorro Murdoch, Victor H. Villar, Raúl V. Durán
Aug 11, 2021
Abstract: Glutamoptosis is the induction of apoptotic cell death as a consequence of the aberrant activation of glutaminolysis and mTORC1 signaling during nutritional imbalance in proliferating cells. The role of the...
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine
Ida M. Modvig, Daniel B. Andersen, Kaare V. Grunddal, Rune E. Kuhre, Christoffer Martinussen, Charlotte B. Christiansen, Cathrine Ørskov, Pierre Larraufie, Richard G. Kay, Frank Reimann, Fiona M. Gribble, Bolette Hartmann, Kirstine N. Bojsen-Møller, Sten Madsbad, Nicolai J. Wewer Albrechtsen, Jens J. Holst
Feb 08, 2021
Abstract: Objectives: Gastrointestinal hormones contribute to the beneficial effects of Roux-en-Y gastric bypass surgery (RYGB) on glycemic control. Secretin is secreted from duodenal S cells in response to low luminal pH, but...
Mild dyslipidemia accelerates tumorigenesis through expansion of Ly6Chi monocytes and differentiation to pro-angiogenic myeloid cells.
Thi Tran, Jean-Remi Lavillegrand, Cedric Lereverend, Bruno Esposito, Lucille Cartier, Melanie Montabord, Jaouen Tran-Rajau, Marc Diedisheim, Nadège Gruel, Khadija Ouguerram, Lea Paolini, Olivia Lenoir, Emmanuel Pinteaux, Eva Brabencova, Corinne Tanchot, Pauline Urquia, Jacqueline Lehmann-Che, Richard Le Naour, Yacine Merrouche, Christian Stockmann, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Eric Tartour, Stephane Potteaux
Sep 15, 2022
Balanced gene dosage control rather than parental origin underpins genomic imprinting.
Ariella Weinberg-Shukron, Raz Ben-Yair, Nozomi Takahashi, Marko Dunjić, Alon Shtrikman, Carol A Edwards, Anne C Ferguson-Smith, Yonatan Stelzer
Jul 29, 2022
Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson’s disease
Wei-Li Kuan, Katherine Stott, Xiaoling He, Tobias C. Wood, Sujeong Yang, Jessica C. F. Kwok, Katie Hall, Yanyan Zhao, Ole Tietz, Franklin I. Aigbirhio, Anthony C. Vernon, Roger A. Barker
Feb 02, 2021
Abstract: Parkinson’s disease (PD) is an α-synucleinopathy characterized by the progressive loss of specific neuronal populations. Here, we develop a novel approach to transvascularly deliver proteins of complex quaternary...
Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line
Claire M. Mulvey, Lisa M. Breckels, Oliver M. Crook, David J. Sanders, Andre L. R. Ribeiro, Aikaterini Geladaki, Andy Christoforou, Nina Kočevar Britovšek, Tracey Hurrell, Michael J. Deery, Laurent Gatto, Andrew M. Smith, Kathryn S. Lilley
Oct 01, 2021
Abstract: Protein localisation and translocation between intracellular compartments underlie almost all physiological processes. The hyperLOPIT proteomics platform combines mass spectrometry with state-of-the-art machine...
Perineuronal nets affect memory and learning after synapse withdrawal.
Jiri Ruzicka, Marketa Dalecka, Kristyna Safrankova, Diego Peretti, Pavla Jendelova, Jessica CF Kwok, James W Fawcett
Nov 15, 2022
Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models....