Search
Results: 23
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
Lorna B. Jarvis, Daniel B. Rainbow, Valerie Coppard, Sarah K. Howlett, Zoya Georgieva, Jessica L. Davies, Harpreet Kaur Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James T. Grist, Alasdair J. Coles, Hani S. Mousa, Stefano Pluchino, Krishnaa T. Mahbubani, Julian L. Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda S. Wicker, Joanne L. Jones
Oct 18, 2021
Abstract: The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro...
A single-cell comparison of adult and fetal human epicardium defines the age-associated changes in epicardial activity
Vincent R. Knight-Schrijver, Hongorzul Davaapil, Semih Bayraktar, Alexander D. B. Ross, Kazumasa Kanemaru, James Cranley, Monika Dabrowska, Minal Patel, Krzysztof Polanski, Xiaoling He, Ludovic Vallier, Sarah Teichmann, Laure Gambardella, Sanjay Sinha
Apr 11, 2023
Hypoxic microenvironment shapes HIV-1 replication and latency
Xiaodong Zhuang, Isabela Pedroza-Pacheco, Isabel Nawroth, Anna E. Kliszczak, Andrea Magri, Wayne Paes, Claudia Orbegozo Rubio, Hongbing Yang, Margaret Ashcroft, David Mole, Peter Balfe, Persephone Borrow, Jane A. McKeating
Jul 14, 2020
Abstract: Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus...
A single-cell comparison of adult and fetal human epicardium defines the age-associated changes in epicardial activity
Vincent R Knight-Schrijver, Hongorzul Davaapil, Semih Bayraktar, Alexander DB Ross, Kazumasa Kanemaru, James Cranley, Monika Dabrowska, Minal Patel, Krzysztof Polanski, Xiaoling He, Ludovic Vallier, Sarah Teichmann, Laure Gambardella, Sanjay Sinha
Dec 22, 2022
Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid
Male-Specific Protein Disulphide Isomerase Function is Essential for Plasmodium Transmission and a Vulnerable Target for Intervention
Fiona Angrisano, Katarzyna A. Sala, Sofia Tapanelli, George K. Christophides, Andrew M. Blagborough
Dec 03, 2020
Abstract: Inhibiting transmission of Plasmodium is an essential strategy in malaria eradication, and the biological process of gamete fusion during fertilization is a proven target for this approach. Lack of knowledge of the...
Inhibition of snake venom induced sterile inflammation and PLA2 activity by Titanium dioxide Nanoparticles in experimental animals
Shubhro Chakrabartty, Md. Iqbal Alam, Saumya Bhagat, Aftab Alam, Neha Dhyani, Gausal A. Khan, M. Sarwar Alam
Jul 31, 2020
Abstract: Sterile inflammation (SI) is an essential process in response to snakebite and injury. The venom induced pathophysiological response to sterile inflammation results into many harmful and deleterious effects that...
Hypoxic microenvironment shapes HIV-1 replication and latency
Xiaodong Zhuang, Isabela Pedroza-Pacheco, Isabel Nawroth, Anna E. Kliszczak, Andrea Magri, Wayne Paes, Claudia Orbegozo Rubio, Hongbing Yang, Margaret Ashcroft, David Mole, Peter Balfe, Persephone Borrow, Jane A. McKeating
Jul 28, 2021
Abstract: Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus...
Asymmetric chromatin retention and nuclear envelopes separate chromosomes in fused cells in vivo.
Bharath Sunchu, Nicole MynYi Lee, Jennifer A Taylor, Roberto Carlos Segura, Chantal Roubinet, Clemens Cabernard
Sep 19, 2022
Hybrid cells derived through fertilization or somatic cell fusion recognize and separate chromosomes of different origins. The underlying mechanisms are unknown but could prevent aneuploidy and tumor formation. Here, we acutely...
A conformational switch controlling the toxicity of the prion protein.
Karl Frontzek, Marco Bardelli, Assunta Senatore, Anna Henzi, Regina R Reimann, Seden Bedir, Marika Marino, Rohanah Hussain, Simon Jurt, Georg Meisl, Mattia Pedotti, Federica Mazzola, Giuliano Siligardi, Oliver Zerbe, Marco Losa, Tuomas Knowles, Asvin Lakkaraju, Caihong Zhu, Petra Schwarz, Simone Hornemann, Matthew G Holt, Luca Simonelli, Luca Varani, Adriano Aguzzi
Aug 12, 2022
Probing the dynamic stalk region of the ribosome using solution NMR
Xiaolin Wang, John P. Kirkpatrick, Hélène M. M. Launay, Alfonso De Simone, Daniel Häussinger, Christopher M. Dobson, Michele Vendruscolo, Lisa D. Cabrita, Christopher A. Waudby, John Christodoulou
Sep 18, 2020
Abstract: We describe an NMR approach based on the measurement of residual dipolar couplings (RDCs) to probe the structural and motional properties of the dynamic regions of the ribosome. Alignment of intact 70S ribosomes in...
Biotin proximity tagging favours unfolded proteins and enables the study of intrinsically disordered regions
Abstract: Intrinsically Disordered Regions (IDRs) are enriched in disease-linked proteins known to have multiple post-translational modifications, but there is limited in vivo information about how locally unfolded protein...
Hypoxic microenvironment shapes HIV-1 replication and latency
Xiaodong Zhuang, Isabela Pedroza-Pacheco, Isabel Nawroth, Anna E. Kliszczak, Andrea Magri, Wayne Paes, Claudia Orbegozo Rubio, Hongbing Yang, Margaret Ashcroft, David Mole, Peter Balfe, Persephone Borrow, Jane A. McKeating
Feb 18, 2021
Abstract: Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus...
Menstrual flow as a non-invasive source of endometrial organoids
Tereza Cindrova-Davies, Xiaohui Zhao, Kay Elder, Carolyn J. P. Jones, Ashley Moffett, Graham J. Burton, Margherita Y. Turco
Jun 18, 2021
C. elegans expressing D76N β 2 -microglobulin
Giulia Faravelli, Sara Raimondi, Loredana Marchese, Frederick A. Partridge, Cristina Soria, P. Patrizia Mangione, Diana Canetti, Michele Perni, Francesco A. Aprile, Irene Zorzoli, Elia Di Schiavi, David A. Lomas, Vittorio Bellotti, David B. Sattelle, Sofia Giorgetti
Dec 26, 2020
A machine learning algorithm to differentiate bipolar disorder from major depressive disorder using an online mental health questionnaire and blood biomarker data
Jakub Tomasik, Sung Yeon Sarah Han, Giles Barton-Owen, Dan-Mircea Mirea, Nayra A. Martin-Key, Nitin Rustogi, Santiago G. Lago, Tony Olmert, Jason D. Cooper, Sureyya Ozcan, Pawel Eljasz, Grégoire Thomas, Robin Tuytten, Tim Metcalfe, Thea S. Schei, Lynn P. Farrag, Lauren V. Friend, Emily Bell, Dan Cowell, Sabine Bahn
Jan 12, 2021
Abstract: The vast personal and economic burden of mood disorders is largely caused by their under- and misdiagnosis, which is associated with ineffective treatment and worsening of outcomes. Here, we aimed to develop a...
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr 1 ]apelin-13 in humans
Duuamene Nyimanu, Richard G. Kay, Petra Sulentic, Rhoda E. Kuc, Philip Ambery, Lutz Jermutus, Frank Reimann, Fiona M. Gribble, Joseph Cheriyan, Janet J. Maguire, Anthony P. Davenport
Dec 26, 2020
Abstract: [Pyr1]apelin-13 is the predominant apelin peptide isoform in the human cardiovascular system and plasma. To date, few studies have investigated [Pyr1]apelin-13 metabolism in vivo in rats with no studies examining its...
Biotin proximity tagging favours unfolded proteins and enables the study of intrinsically disordered regions
Abstract: Intrinsically Disordered Regions (IDRs) are enriched in disease-linked proteins known to have multiple post-translational modifications, but there is limited in vivo information about how locally unfolded protein...
Genetic and chemotherapeutic influences on germline hypermutation.
Joanna Kaplanis, Benjamin Ide, Rashesh Sanghvi, Matthew Neville, Petr Danecek, Tim Coorens, Elena Prigmore, Patrick Short, Giuseppe Gallone, Jeremy McRae, Genomics England Research Consortium, Jenny Carmichael, Angela Barnicoat, Helen Firth, Patrick O'Brien, Raheleh Rahbari, Matthew Hurles
May 18, 2022
Mutations in the germline generates all evolutionary genetic variation and is a cause of genetic disease. Parental age is the primary determinant of the number of new germline mutations in an individual's genome1,2. Here we...
Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation