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Results: 22
Cryo-EM structural analysis of FADD
Joanna L. Fox, Michelle A. Hughes, Xin Meng, Nikola A. Sarnowska, Ian R. Powley, Rebekah Jukes-Jones, David Dinsdale, Timothy J. Ragan, Louise Fairall, John W. R. Schwabe, Nobuhiro Morone, Kelvin Cain, Marion MacFarlane
Feb 05, 2021
Abstract: Regulated cell death is essential in development and cellular homeostasis. Multi-protein platforms, including the Death-Inducing Signaling Complex (DISC), co-ordinate cell fate via a core FADD:Caspase-8 complex and its...
The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver
Natascha Hruschka, Mark Kalisz, Maria Subijana, Osvaldo Graña-Castro, Francisco Del Cano-Ochoa, Laia Paré Brunet, Igor Chernukhin, Ana Sagrera, Aurelien De Reynies, Bernhard Kloesch, Suet-Feung Chin, Octavio Burgués, David Andreu, Begoña Bermejo, Juan Miguel Cejalvo, Joe Sutton, Carlos Caldas, Santiago Ramón-Maiques, Jason S. Carroll, Aleix Prat, Francisco X. Real, Paola Martinelli
Sep 09, 2020
Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia
Luke W. Thomas, Cinzia Esposito, Rachel E. Morgan, Stacey Price, Jamie Young, Steven P. Williams, Lucas A. Maddalena, Ultan McDermott, Margaret Ashcroft
May 21, 2021
The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver
Natascha Hruschka, Mark Kalisz, Maria Subijana, Osvaldo Graña-Castro, Francisco Del Cano-Ochoa, Laia Paré Brunet, Igor Chernukhin, Ana Sagrera, Aurelien De Reynies, Bernhard Kloesch, Suet-Feung Chin, Octavio Burgués, David Andreu, Begoña Bermejo, Juan Miguel Cejalvo, Joe Sutton, Carlos Caldas, Santiago Ramón-Maiques, Jason S. Carroll, Aleix Prat, Francisco X. Real, Paola Martinelli
Jun 25, 2021
Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages
Belén Prados, Raquel Del Toro, Donal MacGrogan, Paula Gómez-Apiñániz, Tania Papoutsi, Pura Muñoz-Cánoves, Simón Méndez-Ferrer, José Luis de la Pompa
Jul 28, 2021
Abstract: Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which...
The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver
Natascha Hruschka, Mark Kalisz, Maria Subijana, Osvaldo Graña-Castro, Francisco Del Cano-Ochoa, Laia Paré Brunet, Igor Chernukhin, Ana Sagrera, Aurelien De Reynies, Bernhard Kloesch, Suet-Feung Chin, Octavio Burgués, David Andreu, Begoña Bermejo, Juan Miguel Cejalvo, Joe Sutton, Carlos Caldas, Santiago Ramón-Maiques, Jason S. Carroll, Aleix Prat, Francisco X. Real, Paola Martinelli
Aug 27, 2020
Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age
Cory M. Willis, Alexandra M. Nicaise, Ernesto R. Bongarzone, Maria Givogri, Cory R. Reiter, Olivia Heintz, Evan R. Jellison, Pearl A. Sutter, Gregg TeHennepe, Guruprasad Ananda, Anthony T. Vella, Stephen J. Crocker
Jan 20, 2021
Abstract: The aging brain is associated with significant changes in physiology that alter the tissue microenvironment of the central nervous system (CNS). In the aged CNS, increased demyelination has been associated with...
Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology.
Alessandra Stangherlin, Joseph L Watson, David CS Wong, Silvia Barbiero, Aiwei Zeng, Estere Seinkmane, Sew Peak Chew, Andrew D Beale, Edward A Hayter, Alina Guna, Alison J Inglis, Marrit Putker, Eline Bartolami, Stefan Matile, Nicolas Lequeux, Thomas Pons, Jason Day, Gerben van Ooijen, Rebecca M Voorhees, David A Bechtold, Emmanuel Derivery, Rachel S Edgar, Peter Newham, John O'Neill
Nov 24, 2021
Between 6-20% of the cellular proteome is under circadian control and tunes mammalian cell function with daily environmental cycles. For cell viability, and to maintain volume within narrow limits, the daily variation in osmotic...
ATR and CDK4/6 inhibition target the growth of methotrexate-resistant choriocarcinoma
Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype
Damir Varešlija, Elspeth Ward, Siobhan P. Purcell, Nicola S. Cosgrove, Sinéad Cocchiglia, Philip J. O’Halloran, Sara Charmsaz, Fiona T. Bane, Francesca M. Brett, Michael Farrell, Jane Cryan, Alan Beausang, Lance Hudson, Arran K. Turnbul, J. Michael Dixon, Arnold D. K. Hill, Nolan Priedigkeit, Steffi Oesterreich, Adrian V. Lee, Andrew H. Sims, Aisling M. Redmond, Jason S. Carroll, Leonie S. Young
Feb 18, 2021
The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver
Natascha Hruschka, Mark Kalisz, Maria Subijana, Osvaldo Graña-Castro, Francisco Del Cano-Ochoa, Laia Paré Brunet, Igor Chernukhin, Ana Sagrera, Aurelien De Reynies, Bernhard Kloesch, Suet-Feung Chin, Octavio Burgués, David Andreu, Begoña Bermejo, Juan Miguel Cejalvo, Joe Sutton, Carlos Caldas, Santiago Ramón-Maiques, Jason S. Carroll, Aleix Prat, Francisco X. Real, Paola Martinelli
Aug 06, 2020
The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver
Natascha Hruschka, Mark Kalisz, Maria Subijana, Osvaldo Graña-Castro, Francisco Del Cano-Ochoa, Laia Paré Brunet, Igor Chernukhin, Ana Sagrera, Aurelien De Reynies, Bernhard Kloesch, Suet-Feung Chin, Octavio Burgués, David Andreu, Begoña Bermejo, Juan Miguel Cejalvo, Joe Sutton, Carlos Caldas, Santiago Ramón-Maiques, Jason S. Carroll, Aleix Prat, Francisco X. Real, Paola Martinelli
Feb 09, 2021
The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
Ricky M. Trigg, Liam C. Lee, Nina Prokoph, Leila Jahangiri, C. Patrick Reynolds, G. A. Amos Burke, Nicola A. Probst, Miaojun Han, Jamie D. Matthews, Hong Kai Lim, Eleanor Manners, Sonia Martinez, Joaquin Pastor, Carmen Blanco-Aparicio, Olaf Merkel, Ines Garces de Los Fayos Alonso, Petra Kodajova, Simone Tangermann, Sandra Högler, Ji Luo, Lukas Kenner, Suzanne D. Turner
Nov 27, 2020
Abstract: Resistance to anaplastic lymphoma kinase (ALK)-targeted therapy in ALK-positive non-small cell lung cancer has been reported, with the majority of acquired resistance mechanisms relying on bypass signaling. To...
article /631/67/70 /631/67/1059/2326 /631/67/1059/602 /631/67/2332 /13/1 /13/2 /13/31 /13/51 /13/89 /13/95 /13/106 /13/109 /38/1 /38/22 /38/23 /38/77 /38/89 /38/90 /38/109 /42/47 /42/89 /45/22 /45/23 /45/41 /45/47 /45/77 /49/22 /49/23 /64/60 /64/110 /82/1 /82/29 /82/51 /96/1 /96/2 /96/31 /96/95 /96/106 article
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Anna Whitehead, Fynn N. Krause, Amy Moran, Amanda D. V. MacCannell, Jason L. Scragg, Ben D. McNally, Edward Boateng, Steven A. Murfitt, Samuel Virtue, John Wright, Jack Garnham, Graeme R. Davies, James Dodgson, Jurgen E. Schneider, Andrew J. Murray, Christopher Church, Antonio Vidal-Puig, Klaus K. Witte, Julian L. Griffin, Lee D. Roberts
Mar 26, 2021
Abstract: Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an...
ROBO3s
Marcel Werner, Anna Dyas, Iwan Parfentev, Geske E Schmidt, Iga K Mieczkowska, Lukas C Müller-Kirschbaum, Claudia Müller, Stefan Kalkhof, Oliver Reinhardt, Henning Urlaub, Frauke Alves, Julia Gallwas, Evangelos Prokakis, Florian Wegwitz
Sep 03, 2022
Basal-like breast cancer (BLBC) is a highly aggressive breast cancer subtype frequently associated with poor prognosis. Due to the scarcity of targeted treatment options, conventional cytotoxic chemotherapies frequently remain...
The receptor PTPRU is a redox sensitive pseudophosphatase
Iain M. Hay, Gareth W. Fearnley, Pablo Rios, Maja Köhn, Hayley J. Sharpe, Janet E. Deane
Jun 26, 2020
Abstract: The receptor-linked protein tyrosine phosphatases (RPTPs) are key regulators of cell-cell communication through the control of cellular phosphotyrosine levels. Most human RPTPs possess an extracellular receptor domain...
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr 1 ]apelin-13 in humans
Duuamene Nyimanu, Richard G. Kay, Petra Sulentic, Rhoda E. Kuc, Philip Ambery, Lutz Jermutus, Frank Reimann, Fiona M. Gribble, Joseph Cheriyan, Janet J. Maguire, Anthony P. Davenport
Dec 26, 2020
Abstract: [Pyr1]apelin-13 is the predominant apelin peptide isoform in the human cardiovascular system and plasma. To date, few studies have investigated [Pyr1]apelin-13 metabolism in vivo in rats with no studies examining its...
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
Clément Bodineau, Mercedes Tomé, Sarah Courtois, Ana S. H. Costa, Marco Sciacovelli, Benoit Rousseau, Elodie Richard, Pierre Vacher, Carlos Parejo-Pérez, Emilie Bessede, Christine Varon, Pierre Soubeyran, Christian Frezza, Piedad Del Socorro Murdoch, Victor H. Villar, Raúl V. Durán
Aug 11, 2021
Abstract: Glutamoptosis is the induction of apoptotic cell death as a consequence of the aberrant activation of glutaminolysis and mTORC1 signaling during nutritional imbalance in proliferating cells. The role of the...
Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology
Alessandra Stangherlin, Joseph L. Watson, David C. S. Wong, Silvia Barbiero, Aiwei Zeng, Estere Seinkmane, Sew Peak Chew, Andrew D. Beale, Edward A. Hayter, Alina Guna, Alison J. Inglis, Marrit Putker, Eline Bartolami, Stefan Matile, Nicolas Lequeux, Thomas Pons, Jason Day, Gerben van Ooijen, Rebecca M. Voorhees, David A. Bechtold, Emmanuel Derivery, Rachel S. Edgar, Peter Newham, John S. O’Neill
Oct 18, 2021
Abstract: Between 6–20% of the cellular proteome is under circadian control and tunes mammalian cell function with daily environmental cycles. For cell viability, and to maintain volume within narrow limits, the daily variation...
ATR and CDK4/6 inhibition target the growth of methotrexate-resistant choriocarcinoma.
Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson’s disease
Wei-Li Kuan, Katherine Stott, Xiaoling He, Tobias C. Wood, Sujeong Yang, Jessica C. F. Kwok, Katie Hall, Yanyan Zhao, Ole Tietz, Franklin I. Aigbirhio, Anthony C. Vernon, Roger A. Barker
Feb 02, 2021
Abstract: Parkinson’s disease (PD) is an α-synucleinopathy characterized by the progressive loss of specific neuronal populations. Here, we develop a novel approach to transvascularly deliver proteins of complex quaternary...
The receptor PTPRU is a redox sensitive pseudophosphatase
Iain M. Hay, Gareth W. Fearnley, Pablo Rios, Maja Köhn, Hayley J. Sharpe, Janet E. Deane
Jun 26, 2021
Abstract: The receptor-linked protein tyrosine phosphatases (RPTPs) are key regulators of cell-cell communication through the control of cellular phosphotyrosine levels. Most human RPTPs possess an extracellular receptor domain...