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Results: 9
Alpha synuclein aggregation drives ferroptosis
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Oct 02, 2020
Abstract: Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death...
Cryo-EM structural analysis of FADD
Joanna L. Fox, Michelle A. Hughes, Xin Meng, Nikola A. Sarnowska, Ian R. Powley, Rebekah Jukes-Jones, David Dinsdale, Timothy J. Ragan, Louise Fairall, John W. R. Schwabe, Nobuhiro Morone, Kelvin Cain, Marion MacFarlane
Feb 05, 2021
Abstract: Regulated cell death is essential in development and cellular homeostasis. Multi-protein platforms, including the Death-Inducing Signaling Complex (DISC), co-ordinate cell fate via a core FADD:Caspase-8 complex and its...
Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape.
Maurizio Mangolini, Alba Maiques-Diaz, Stella Charalampopoulou, Elena Gerhard-Hartmann, Johannes Bloehdorn, Andrew Moore, Giorgia Giachetti, Junyan Lu, Valar Nila Roamio Franklin, Chandra Sekkar Reddy Chilamakuri, Ilias Moutsopoulos, Andreas Rosenwald, Stephan Stilgenbauer, Thorsten Zenz, Irina Mohorianu, Clive D'Santos, Silvia Deaglio, Daniel J Hodson, Jose I Martin-Subero, Ingo Ringshausen
Oct 24, 2022
Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis, we have generated isogenic primary human tumor cells...
Alpha synuclein aggregation drives ferroptosis
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Oct 12, 2020
Abstract: Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death...
Alpha synuclein aggregation drives ferroptosis
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Feb 09, 2021
Abstract: Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death...
Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism.
Binyamin Duethorn, Fabian Groll, Bettina Rieger, Hannes CA Drexler, Heike Brinkmann, Ludmila Kremer, Martin Stehling, Marie-Theres Borowski, Karina Mildner, Dagmar Zeuschner, Magdalena Zernicka-Goetz, Marc P Stemmler, Karin B Busch, Juan M Vaquerizas, Ivan Bedzhov
Feb 01, 2022
Lima1 is an extensively studied prognostic marker of malignancy and is also considered to be a tumour suppressor, but its role in a developmental context of non-transformed cells is poorly understood. Here, we characterise the...
Alpha synuclein aggregation drives ferroptosis
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S. Dolt, Tilo Kunath, Michael J. Devine, Paul Gissen, Mikhail S. Shchepinov, Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Sep 16, 2020
Abstract: Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death...
The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
Ricky M. Trigg, Liam C. Lee, Nina Prokoph, Leila Jahangiri, C. Patrick Reynolds, G. A. Amos Burke, Nicola A. Probst, Miaojun Han, Jamie D. Matthews, Hong Kai Lim, Eleanor Manners, Sonia Martinez, Joaquin Pastor, Carmen Blanco-Aparicio, Olaf Merkel, Ines Garces de Los Fayos Alonso, Petra Kodajova, Simone Tangermann, Sandra Högler, Ji Luo, Lukas Kenner, Suzanne D. Turner
Nov 27, 2020
Abstract: Resistance to anaplastic lymphoma kinase (ALK)-targeted therapy in ALK-positive non-small cell lung cancer has been reported, with the majority of acquired resistance mechanisms relying on bypass signaling. To...
article /631/67/70 /631/67/1059/2326 /631/67/1059/602 /631/67/2332 /13/1 /13/2 /13/31 /13/51 /13/89 /13/95 /13/106 /13/109 /38/1 /38/22 /38/23 /38/77 /38/89 /38/90 /38/109 /42/47 /42/89 /45/22 /45/23 /45/41 /45/47 /45/77 /49/22 /49/23 /64/60 /64/110 /82/1 /82/29 /82/51 /96/1 /96/2 /96/31 /96/95 /96/106 article
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
Clément Bodineau, Mercedes Tomé, Sarah Courtois, Ana S. H. Costa, Marco Sciacovelli, Benoit Rousseau, Elodie Richard, Pierre Vacher, Carlos Parejo-Pérez, Emilie Bessede, Christine Varon, Pierre Soubeyran, Christian Frezza, Piedad Del Socorro Murdoch, Victor H. Villar, Raúl V. Durán
Aug 11, 2021
Abstract: Glutamoptosis is the induction of apoptotic cell death as a consequence of the aberrant activation of glutaminolysis and mTORC1 signaling during nutritional imbalance in proliferating cells. The role of the...