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Results: 9
Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
Caroline Coombs, Antonios Georgantzoglou, Hazel A. Walker, Julian Patt, Nicole Merten, Hugo Poplimont, Elisabeth M. Busch-Nentwich, Sarah Williams, Christina Kotsi, Evi Kostenis, Milka Sarris
Nov 13, 2020
Abstract: Immune cells congregate at specific loci to fight infections during inflammatory responses, a process that must be transient and self-resolving. Cell dispersal promotes resolution, but it remains unclear how transition...
Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
Silvia Basilico, Xiaonan Wang, Alison Kennedy, Konstantinos Tzelepis, George Giotopoulos, Sarah J. Kinston, Pedro M. Quiros, Kim Wong, David J. Adams, Larissa S. Carnevalli, Brian J. P. Huntly, George S. Vassiliou, Fernando J. Calero-Nieto, Berthold Göttgens
Mar 16, 2021
Abstract: Leukaemogenic mutations commonly disrupt cellular differentiation and/or enhance proliferation, thus perturbing the regulatory programs that control self-renewal and differentiation of stem and progenitor cells....
Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity
Joachim Hanna, Flavio Beke, Louise M O’Brien, Chrysa Kapeni, Hung-Chang Chen, Valentina Carbonaro, Alexander B Kim, Kamal Kishore, Timon E Adolph, Mikkel-Ole Skjoedt, Karsten Skjoedt, Marc de la Roche, Maike de la Roche
Jul 14, 2022
The immuno-behavioural covariation associated with the treatment response to bumetanide in young children with autism spectrum disorder.
Qingyang Li, Lingli Zhang, Haidi Shan, Juehua Yu, Yuan Dai, Hua He, Wei-Guang Li, Christelle Langley, Barbara Sahakian, Yin Yao, Qiang Luo, Fei Li
Jun 07, 2022
Bumetanide, a drug being studied in autism spectrum disorder (ASD) may act to restore gamma-aminobutyric acid (GABA) function, which may be modulated by the immune system. However, the interaction between bumetanide and the...
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy.
Marcel P Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C Stinchcombe, Michal A Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S Thommen, Gillian M Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius
Feb 02, 2023
Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10.
Jingxu Guo, Bin Liu, Midory Thorikay, Minmin Yu, Xiaoyan Li, Zhen Tong, Richard M Salmon, Randy Read, Peter Ten Dijke, Nicholas Morrell, Wei Li
May 09, 2022
Heterozygous mutations in BMPR2 (bone morphogenetic protein (BMP) receptor type II) cause pulmonary arterial hypertension. BMPRII is a receptor for over 15 BMP ligands, but why BMPR2 mutations cause lung-specific pathology is...
Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti.
Yoann Saucereau, Thomas H Wilson, Matthew CK Tang, Martin C Moncrieffe, Steven W Hardwick, Dimitri Y Chirgadze, Sandro G Soares, Maria Jose Marcaida, Nicholas J Gay, Monique Gangloff
Sep 02, 2022
Aedes aegypti has evolved to become an efficient vector for arboviruses but the mechanisms of host-pathogen tolerance are unknown. Immunoreceptor Toll and its ligand Spaetzle have undergone duplication which may allow...
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Sep 22, 2021
Abstract: Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL....
Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses
Jonathan X Meng, Yu Zhang, Dominik Saman, Arshad M Haider, Suman De, Jason C Sang, Karen Brown, Kun Jiang, Jane Humphrey, Linda Julian, Eric Hidari, Steven F Lee, Gabriel Balmus, R Andres Floto, Clare Bryant, Justin LP Benesch, Yu Ye, David Klenerman
May 16, 2022