Search
Results: 28
ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
Peter S. J. Bailey, Brian M. Ortmann, Anthony W. Martinelli, Jack W. Houghton, Ana S. H. Costa, Stephen P. Burr, Robin Antrobus, Christian Frezza, James A. Nathan
Aug 13, 2020
Abstract: 2-oxoglutarate (2-OG or α-ketoglutarate) relates mitochondrial metabolism to cell function by modulating the activity of 2-OG dependent dioxygenases involved in the hypoxia response and DNA/histone modifications....
Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms
Richard M. Salmon, Jingxu Guo, Jennifer H. Wood, Zhen Tong, John S. Beech, Aleksandra Lawera, Minmin Yu, David J. Grainger, Jill Reckless, Nicholas W. Morrell, Wei Li
Apr 01, 2021
Abstract: Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. However...
Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
Caroline Coombs, Antonios Georgantzoglou, Hazel A. Walker, Julian Patt, Nicole Merten, Hugo Poplimont, Elisabeth M. Busch-Nentwich, Sarah Williams, Christina Kotsi, Evi Kostenis, Milka Sarris
Nov 13, 2020
Abstract: Immune cells congregate at specific loci to fight infections during inflammatory responses, a process that must be transient and self-resolving. Cell dispersal promotes resolution, but it remains unclear how transition...
Phosphorylation by Aurora B kinase regulates caspase-2 activity and function
Yoon Lim, Dylan De Bellis, Jarrod J. Sandow, Luisa Capalbo, Pier Paolo D’Avino, James M. Murphy, Andrew I. Webb, Loretta Dorstyn, Sharad Kumar
Feb 09, 2021
Abstract: Mitotic catastrophe (MC) is an important oncosuppressive mechanism that serves to eliminate cells that become polyploid or aneuploid due to aberrant mitosis. Previous studies have demonstrated that the activation and...
Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape.
Maurizio Mangolini, Alba Maiques-Diaz, Stella Charalampopoulou, Elena Gerhard-Hartmann, Johannes Bloehdorn, Andrew Moore, Giorgia Giachetti, Junyan Lu, Valar Nila Roamio Franklin, Chandra Sekkar Reddy Chilamakuri, Ilias Moutsopoulos, Andreas Rosenwald, Stephan Stilgenbauer, Thorsten Zenz, Irina Mohorianu, Clive D'Santos, Silvia Deaglio, Daniel J Hodson, Jose I Martin-Subero, Ingo Ringshausen
Oct 24, 2022
Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis, we have generated isogenic primary human tumor cells...
Molecular characterization of a marine turtle tumor epizootic, profiling external, internal and postsurgical regrowth tumors
Kelsey Yetsko, Jessica A. Farrell, Nicholas B. Blackburn, Liam Whitmore, Maximilian R. Stammnitz, Jenny Whilde, Catherine B. Eastman, Devon Rollinson Ramia, Rachel Thomas, Aleksandar Krstic, Paul Linser, Simon Creer, Gary Carvalho, Mariana A. Devlin, Nina Nahvi, Ana Cristina Leandro, Thomas W. deMaar, Brooke Burkhalter, Elizabeth P. Murchison, Christine Schnitzler, David J. Duffy
Feb 01, 2021
Abstract: Sea turtle populations are under threat from an epizootic tumor disease (animal epidemic) known as fibropapillomatosis. Fibropapillomatosis continues to spread geographically, with prevalence of the disease also...
Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D. Upton, Sonja Loges, Nicholas W. Morrell, Werner Seeger, Ralph T. Schermuly
Jan 28, 2022
Abstract: Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e....
Phosphorylation by Aurora B kinase regulates caspase-2 activity and function
Yoon Lim, Dylan De Bellis, Jarrod J. Sandow, Luisa Capalbo, Pier Paolo D’Avino, James M. Murphy, Andrew I. Webb, Loretta Dorstyn, Sharad Kumar
Aug 18, 2021
Abstract: Mitotic catastrophe (MC) is an important oncosuppressive mechanism that serves to eliminate cells that become polyploid or aneuploid due to aberrant mitosis. Previous studies have demonstrated that the activation and...
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
Max T. B. Clabbers, Susannah Holmes, Timothy W. Muusse, Parimala R. Vajjhala, Sara J. Thygesen, Alpeshkumar K. Malde, Dominic J. B. Hunter, Tristan I. Croll, Leonie Flueckiger, Jeffrey D. Nanson, Md. Habibur Rahaman, Andrew Aquila, Mark S. Hunter, Mengning Liang, Chun Hong Yoon, Jingjing Zhao, Nadia A. Zatsepin, Brian Abbey, Emma Sierecki, Yann Gambin, Katryn J. Stacey, Connie Darmanin, Bostjan Kobe, Hongyi Xu, Thomas Ve
May 10, 2021
Abstract: MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms filaments in vitro and induces formation...
IDO1 + Paneth cells promote immune escape of colorectal cancer
Sandra Pflügler, Jasmin Svinka, Irene Scharf, Ilija Crncec, Martin Filipits, Pornpimol Charoentong, Markus Tschurtschenthaler, Lukas Kenner, Monira Awad, Judith Stift, Marina Schernthanner, Romana Bischl, Dietmar Herndler-Brandstetter, Elisabeth Glitzner, Herwig P. Moll, Emilio Casanova, Gerald Timelthaler, Maria Sibilia, Michael Gnant, Sigurd Lax, Josef Thaler, Mathias Müller, Birgit Strobl, Thomas Mohr, Arthur Kaser, Zlatko Trajanoski, Gerwin Heller, Robert Eferl
Feb 18, 2021
Abstract: Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune...
Resonance energy transfer sensitises and monitors in situ switching of LOV2-based optogenetic actuators
Li-Li Li, Florence M. Klein, Lorenzo Li Greci, Arkadiusz Popinigis, Florian Freudenberg, Michael J. Courtney
Oct 09, 2020
Characterisation of proguanylin expressing cells in the intestine – evidence for constitutive luminal secretion
Florent Serge Dye, Pierre Larraufie, Richard Kay, Tamana Darwish, Juraj Rievaj, Deborah A. Goldspink, Claire L. Meek, Stephen J. Middleton, Richard H. Hardwick, Geoffrey P. Roberts, Jennifer L. Percival-Alwyn, Tris Vaughan, Franco Ferraro, Benjamin G. Challis, Stephen O’Rahilly, Maria Groves, Fiona M. Gribble, Frank Reimann
Oct 29, 2020
Abstract: Guanylin, a peptide implicated in regulation of intestinal fluid secretion, is expressed in the mucosa, but the exact cellular origin remains controversial. In a new transgenic mouse model fluorescent reporter protein...
A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding
Jerome Jatzlau, Wiktor Burdzinski, Michael Trumpp, Leon Obendorf, Kilian Roßmann, Katharina Ravn, Marko Hyvönen, Francesca Bottanelli, Johannes Broichhagen, Petra Knaus
Jan 25, 2023
Published by: Nature Publishing Group UK
The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
Ricky M. Trigg, Liam C. Lee, Nina Prokoph, Leila Jahangiri, C. Patrick Reynolds, G. A. Amos Burke, Nicola A. Probst, Miaojun Han, Jamie D. Matthews, Hong Kai Lim, Eleanor Manners, Sonia Martinez, Joaquin Pastor, Carmen Blanco-Aparicio, Olaf Merkel, Ines Garces de Los Fayos Alonso, Petra Kodajova, Simone Tangermann, Sandra Högler, Ji Luo, Lukas Kenner, Suzanne D. Turner
Nov 27, 2020
Abstract: Resistance to anaplastic lymphoma kinase (ALK)-targeted therapy in ALK-positive non-small cell lung cancer has been reported, with the majority of acquired resistance mechanisms relying on bypass signaling. To...
article /631/67/70 /631/67/1059/2326 /631/67/1059/602 /631/67/2332 /13/1 /13/2 /13/31 /13/51 /13/89 /13/95 /13/106 /13/109 /38/1 /38/22 /38/23 /38/77 /38/89 /38/90 /38/109 /42/47 /42/89 /45/22 /45/23 /45/41 /45/47 /45/77 /49/22 /49/23 /64/60 /64/110 /82/1 /82/29 /82/51 /96/1 /96/2 /96/31 /96/95 /96/106 article
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Sep 22, 2021
Abstract: Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL....
The negative regulator SMAX1 controls mycorrhizal symbiosis and strigolactone biosynthesis in rice
Jeongmin Choi, Tak Lee, Jungnam Cho, Emily K. Servante, Boas Pucker, William Summers, Sarah Bowden, Mehran Rahimi, Kyungsook An, Gynheung An, Harro J. Bouwmeester, Emma J. Wallington, Giles Oldroyd, Uta. Paszkowski
Apr 30, 2021
Abstract: Most plants associate with beneficial arbuscular mycorrhizal (AM) fungi that facilitate soil nutrient acquisition. Prior to contact, partner recognition triggers reciprocal genetic remodelling to enable colonisation....
Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies
Timo W. M. De Groof, Elizabeth G. Elder, Eleanor Y. Lim, Raimond Heukers, Nick D. Bergkamp, Ian J. Groves, Mark Wills, John H. Sinclair, Martine J. Smit
Jul 28, 2021
Abstract: Latent human cytomegalovirus (HCMV) infection is characterized by limited gene expression, making latent HCMV infections refractory to current treatments targeting viral replication. However, reactivation of latent...
CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells
Ashley J. Clark, Niamh Mullooly, Dewi Safitri, Matthew Harris, Tessa de Vries, Antoinette MaassenVanDenBrink, David R. Poyner, Davide Gianni, Mark Wigglesworth, Graham Ladds
Jun 23, 2021
Abstract: Agonist bias occurs when different ligands produce distinct signalling outputs when acting at the same receptor. However, its physiological relevance is not always clear. Using primary human cells and gene editing...
ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
Peter S. J. Bailey, Brian M. Ortmann, Anthony W. Martinelli, Jack W. Houghton, Ana S. H. Costa, Stephen P. Burr, Robin Antrobus, Christian Frezza, James A. Nathan
Aug 13, 2021
Abstract: 2-oxoglutarate (2-OG or α-ketoglutarate) relates mitochondrial metabolism to cell function by modulating the activity of 2-OG dependent dioxygenases involved in the hypoxia response and DNA/histone modifications....
Phosphorylation by Aurora B kinase regulates caspase-2 activity and function
Yoon Lim, Dylan De Bellis, Jarrod J. Sandow, Luisa Capalbo, Pier Paolo D’Avino, James M. Murphy, Andrew I. Webb, Loretta Dorstyn, Sharad Kumar
Jan 07, 2021
Abstract: Mitotic catastrophe (MC) is an important oncosuppressive mechanism that serves to eliminate cells that become polyploid or aneuploid due to aberrant mitosis. Previous studies have demonstrated that the activation and...
Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression.
Mark J Wall, Emily Hill, Robert Huckstepp, Kerry Barkan, Giuseppe Deganutti, Michele Leuenberger, Barbara Preti, Ian Winfield, Sabrina Carvalho, Anna Suchankova, Haifeng Wei, Dewi Safitri, Xianglin Huang, Wendy Imlach, Circe La Mache, Eve Dean, Cherise Hume, Stephanie Hayward, Jess Oliver, Fei-Yue Zhao, David Spanswick, Christopher A Reynolds, Martin Lochner, Graham Ladds, Bruno G Frenguelli
Jul 18, 2022
The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity of GPCRs to couple to multiple intracellular signalling pathways. This promiscuous coupling leads to numerous...
Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos
Abstract: In all metazoans, a small number of evolutionarily conserved signaling pathways are reiteratively used during development to orchestrate critical patterning and morphogenetic processes. Among these, Notch (N) signaling...
Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D. Upton, Sonja Loges, Nicholas W. Morrell, Werner Seeger, Ralph T. Schermuly
Aug 26, 2021
Abstract: Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e....
|
|< |
< |
1 |