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Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction.
Roberto Costa, Roberta Peruzzo, Magdalena Bachmann, Giulia Dalla Montà, Mattia Vicario, Giulia Santinon, Andrea Mattarei, Enrico Moro, Rubén Quintana-Cabrera, Luca Scorrano, Massimo Zeviani, Francesca Vallese, Mario Zoratti, Cristina Paradisi, Francesco Argenton, Marisa Brini, Tito Calì, Sirio Dupont, Ildikò Szabò, Luigi Leanza
Sep 13, 2019
Wnt signaling affects fundamental development pathways and, if aberrantly activated, promotes the development of cancers. Wnt signaling is modulated by different factors, but whether the mitochondrial energetic state affects Wnt...
PARP10 influences the proliferation of colorectal carcinoma cells, a preliminary study
ChengFang Wu, Ming Xiao, Yalan Wang, Michael Threadgill, Ming Li, Yi Tang, Xiao Lin, Lian Yang, QingShu Li, Xian Li
Mar 31, 2020
PARP10 is an intracellular mono-ADP ribosyltransferase and recent reports suggest that it regulates proliferation of some cell types. However, its effect on the proliferation of colorectal carcinoma cells has not yet been...
Vaccinia virus protein A49 activates Wnt signalling by targetting the E3 ligase β-TrCP.
Vaccinia virus (VACV) encodes multiple proteins inhibiting the NF-κB signalling pathway. One of these, A49, targets the E3 ubiquitin ligase β-TrCP, which is responsible for the ubiquitylation and consequential proteosomal...
Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.
Emanuel Rognoni, Celine Gomez, Angela Oliveira Pisco, Emma L Rawlins, Ben D Simons, Fiona M Watt, Ryan R Driskell
Aug 17, 2018
New hair follicles (HFs) do not form in adult mammalian skin unless epidermal Wnt signalling is activated genetically or within large wounds. To understand the postnatal loss of hair forming ability we monitored HF formation at...
Fibroblast lineages Wounding β-catenin aging Animals Animals Newborn Apoptosis Biomarkers Cell Count Cell Differentiation Cell Proliferation Clone Cells Dermis FIBROBLASTS Gene Expression Profiling Gene Expression Regulation Developmental Green Fluorescent Proteins Hair Follicle Homeostasis Integrases Mice Inbred C57BL Organogenesis Receptor Platelet-Derived Growth Factor alpha Regeneration Signal Transduction Tail Time Factors Wnt Signaling Pathway Wound Healing beta Catenin
PARP10 influences the proliferation of colorectal carcinoma cells, a preliminary study
ChengFang Wu, Ming Xiao, Yalan Wang, Michael Threadgill, Ming Li, Yi Tang, Xiao Lin, Lian Yang, QingShu Li, Xian Li
Mar 31, 2020
PARP10 is an intracellular mono-ADP ribosyltransferase and recent reports suggest that it regulates proliferation of some cell types. However, its effect on the proliferation of colorectal carcinoma cells has not yet been...