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Association of thirty-year alcohol consumption typologies and fatty liver
Smoking, alcohol consumption, and 24 gastrointestinal diseases
Shuai Yuan, Jie Chen, Xixian Ruan, Yuhao Sun, Ke Zhang, Xiaoyan Wang, Xue Li, Dipender Gill, Stephen Burgess, Edward Giovannucci, Susanna C Larsson
Mar 15, 2023
Mendelian randomization alcohol consumption EPIDEMIOLOGY Gastrointestinal Diseases Genetics Genomics Global Health None Smoking Humans Mendelian Randomization Analysis Genetic Predisposition to Disease Duodenal Ulcer Smoking Alcohol Drinking Esophageal Neoplasms Liver Diseases Alcoholic Gastritis Pancreatitis Chronic Genome-Wide Association Study Polymorphism Single Nucleotide
Alcohol use disorders and the heart.
Alcohol use is an important preventable and modifiable cause of non-communicable disease, and has complex effects on the cardiovascular system that vary with dose. Observational and prospective studies have consistently shown a...
Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol-Induced Liver Damage.
Jeremy P Koelmel, Wan Y Tan, Yang Li, John A Bowden, Atiye Ahmadireskety, Andrew C Patt, David J Orlicky, Ewy Mathé, Nicholas M Kroeger, David C Thompson, Jason A Cochran, Jaya Prakash Golla, Aikaterini Kandyliari, Ying Chen, Georgia Charkoftaki, Joy D Guingab-Cagmat, Hiroshi Tsugawa, Anmol Arora, Kirill Veselkov, Shunji Kato, Yurika Otoki, Kiyotaka Nakagawa, Richard A Yost, Timothy J Garrett, Vasilis Vasiliou
Nov 23, 2021
Alcoholic fatty liver disease (AFLD) is characterized by lipid accumulation and inflammation and can progress to cirrhosis and cancer in the liver. AFLD diagnosis currently relies on histological analysis of liver biopsies....
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease.
Connor A Emdin, Mary E Haas, Amit V Khera, Krishna Aragam, Mark Chaffin, Derek Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, Qiping Feng, Juha Karjalainen, Aki Havulinna, Tuomo Kiiskinen, Alexander Bick, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Ben Voight, Scott Damrauer, Julie Lynch, David Kaplan, Marina Serper, Philip Tsao, Million Veteran Program, Josep Mercader, Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
May 16, 2020
Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene (MARC1 p.A165T) that associates with protection...
Reversal of murine alcoholic steatohepatitis by pepducin-based functional blockade of interleukin-8 receptors.
Verena Wieser, Timon E Adolph, Barbara Enrich, Athan Kuliopulos, Arthur Kaser, Herbert Tilg, Nicole C Kaneider
Dec 08, 2015
ALCOHOLIC LIVER DISEASE IMMUNE-MEDIATED LIVER DAMAGE INTERLEUKIN 8 Leukocytes Alanine Transaminase Animals Aspartate Aminotransferases Caspase 1 Chemokine CXCL1 Chemotaxis Fatty Liver Alcoholic Female Hep G2 Cells Hepatitis Hepatocytes Humans Interleukin-1beta Lipid Metabolism Lipopeptides Mice Mice Inbred C57BL Neutrophils Peroxidase Receptors Interleukin-8A Receptors Interleukin-8B Signal Transduction Survival Rate Transcription Genetic Triglycerides Tumor Necrosis Factor-alpha Weight Loss
In vivo imaging of hepatic neutrophil migration in severe alcoholic hepatitis with 111In-radiolabelled leucocytes.
Jonathan R Potts, Neda Farahi, Mark R Howard, Mark R Taylor, Sarah Heard, Arun N Shankar, Graeme J Alexander, Edwin R Chilvers, Sumita Verma, A Michael Peters
Aug 16, 2018
Gathering momentum for the way ahead
Roger Williams, Graeme Alexander, Richard Aspinall, Rachel Batterham, Neeraj Bhala, Nick Bosanquet, Katherine Severi, Anya Burton, Robyn Burton, Matthew E Cramp, Natalie Day, Anil Dhawan, John Dillon, Colin Drummond, Jessica Dyson, James Ferguson, Graham R Foster, Ian Gilmore, Jonny Greenberg, Clive Henn, Mark Hudson, Helen Jarvis, Deirdre Kelly, Jake Mann, Neil McDougall, Martin McKee, Kieran Moriarty, Joanne Morling, Philip Newsome, John O'Grady, Liz Rolfe, Peter Rice, Harry Rutter, Nick Sheron, Douglas Thorburn, Julia Verne, Jyotsna Vohra, John Wass, Andrew Yeoman
May 02, 2019
This report presents further evidence on the escalating alcohol consumption in the UK and the burden of liver disease associated with this major risk factor, as well as the effects on hospital and primary care. We reiterate the...
Alcohol Drinking Alcoholic Beverages Comorbidity Costs and Cost Analysis Disease Eradication Disease Progression Female Food Industry Health Policy Hepatitis B Chronic Hepatitis C Chronic Hospital Mortality Humans Liver Diseases Liver Diseases Alcoholic Lobbying Male Neoplasms obesity prevalence United Kingdom
Convergent somatic mutations in metabolism genes in chronic liver disease.
Stanley WK Ng, Foad J Rouhani, Simon F Brunner, Natalia Brzozowska, Sarah J Aitken, Ming Yang, Federico Abascal, Luiza Moore, Efterpi Nikitopoulou, Lia Chappell, Daniel Leongamornlert, Aleksandra Ivovic, Philip Robinson, Timothy Butler, Mathijs A Sanders, Nicholas Williams, Tim HH Coorens, Jon Teague, Keiran Raine, Adam P Butler, Yvette Hooks, Beverley Wilson, Natalie Birtchnell, Huw Naylor, Susan E Davies, Michael R Stratton, Iñigo Martincorena, Raheleh Rahbari, Christian Frezza, Matthew Hoare, Peter J Campbell
Sep 01, 2021
The progression of chronic liver disease to hepatocellular carcinoma is caused by the acquisition of somatic mutations that affect 20-30 cancer genes1-8. Burdens of somatic mutations are higher and clonal expansions larger in...