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Partial human Janus kinase 1 deficiency predominantly impairs responses to interferon gamma and intracellular control of mycobacteria.
Vanessa Daza-Cajigal, Adriana S Albuquerque, Dan F Young, Michael J Ciancanelli, Dale Moulding, Ivan Angulo, Valentine Jeanne-Julien, Jérémie Rosain, Ekaterina Minskaia, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis, Jacinta Bustamante, Richard E Randall, Timothy D McHugh, Adrian J Thrasher, Siobhan O Burns
Oct 28, 2022
PURPOSE: Janus kinase-1 (JAK1) tyrosine kinase mediates signaling from multiple cytokine receptors, including interferon alpha/beta and gamma (IFN-α/β and IFN-γ), which are important for viral and mycobacterial protection...
Cell-Surface Proteomics Identifies Differences in Signaling and Adhesion Protein Expression between Naive and Primed Human Pluripotent Stem Cells.
Katarzyna Wojdyla, Amanda J Collier, Charlene Fabian, Paola S Nisi, Laura Biggins, David Oxley, Peter J Rugg-Gunn
Jun 08, 2020
Naive and primed human pluripotent stem cells (hPSC) provide valuable models to study cellular and molecular developmental processes. The lack of detailed information about cell-surface protein expression in these two...
JAK-STAT cell state cell-surface markers embryonic human plasma membrane pluripotent stem cell Proteomics reprogramming Cell Adhesion Cell Adhesion Molecules Cell Line Cell Membrane Folate Receptor 1 Humans Induced Pluripotent Stem Cells Membrane Glycoproteins Proteome Receptors Cytokine Signal Transduction
Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms
The myeloproliferative neoplasms are a heterogeneous group of clonal disorders characterized by the overproduction of mature cells in the peripheral blood, together with an increased risk of thrombosis and progression to acute...