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Results: 18
Acquired CARD11 mutation promotes BCR independence in Diffuse Large B Cell Lymphoma.
Rebecca Caeser, Ieuan Walker, Jie Gao, Nimish Shah, Livia Rasso-Barnett, Shubha Anand, Jose-Ezequiel Martin, Daniel J Hodson
Nov 27, 2020
Distinct genetic changes reveal evolutionary history and heterogeneous molecular grade of DLBCL with MYC/BCL2 double-hit.
Francesco Cucco, Sharon Barrans, Chulin Sha, Alexandra Clipson, Simon Crouch, Rachel Dobson, Zi Chen, Joe Sneath Thompson, Matthew A Care, Thomas Cummin, Josh Caddy, Hongxiang Liu, Anne Robinson, Anna Schuh, Jude Fitzgibbon, Daniel Painter, Alexandra Smith, Eve Roman, Reuben Tooze, Catherine Burton, Andrew J Davies, David R Westhead, Peter WM Johnson, Ming-Qing Du
Nov 22, 2019
Using a Burkitt lymphoma-like gene expression signature, we recently defined a high-risk molecular high-grade (MHG) group mainly within germinal centre B-cell like diffuse large B-cell lymphomas (GCB-DLBCL), which was enriched...
Biomarkers Tumor Clonal Evolution Female Gene Expression Profiling Gene Expression Regulation Leukemic Gene Rearrangement Humans Lymphoma Large B-Cell Diffuse Male Middle Aged Mutation Phenotype Prognosis Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-myc Survival Rate Translocation Genetic
A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma.
E Horvilleur, T Sbarrato, K Hill, RV Spriggs, M Screen, PJ Goodrem, K Sawicka, LC Chaplin, C Touriol, G Packham, KN Potter, S Dirnhofer, A Tzankov, MJS Dyer, M Bushell, M MacFarlane, AE Willis
Oct 18, 2018
Dysregulated expression of factors that control protein synthesis is associated with poor prognosis of many cancers, but the underlying mechanisms are not well defined. Analysis of the diffuse large B-cell lymphoma (DLBCL)...
DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes.
Atish Kizhakeyil, Nurmahirah Binte Mohammed Zaini, Zhi Sheng Poh, Brandon Han Siang Wong, Xinpeng Loh, Aik Seng Ng, Zun Siong Low, Praseetha Prasannan, Chun Gong, Michelle Guet Khim Tan, Chandramouli Nagarajan, Dachuan Huang, Pang Wan Lu, Jing Quan Lim, Sharon Barrans, Choon Kiat Ong, Soon Thye Lim, Wee Joo Chng, George Follows, Daniel J Hodson, Ming Qing Du, Yeow Tee Goh, Suat Hoon Tan, Nicholas Francis Grigoropoulos, Navin Kumar Verma
Oct 22, 2021
DDX3X mutation Drug Resistance Hematolymphoid malignancy Prognosis Tumour metastasis Antineoplastic Agents Biomarkers Tumor Cell Line Tumor Cyclin D1 DEAD-box RNA Helicases Disease Progression Drug Resistance Neoplasm Humans Lymphoma Large B-Cell Diffuse Lymphoma Non-Hodgkin Mitogen-Activated Protein Kinases Mutation Prognosis STAT3 Transcription Factor Exome Sequencing
Molecular profiling in diffuse large B-cell lymphoma
The term diffuse large B-cell lymphoma (DLBCL) includes a heterogeneous collection of biologically distinct tumours. This heterogeneity currently presents a barrier to the successful deployment of novel, biologically targeted...
Epstein-Barr-virus-positive large B-cell lymphoma associated with breast implants
L Jeffrey Medeiros, Mario L Marques-Piubelli, Valentina FI Sangiorgio, Roberto Ruiz-Cordero, Francisco Vega, Andrew L Feldman, Jennifer R Chapman, Mark W Clemens, Kelly K Hunt, Mark G Evans, Christine Khoo, Stephen Lade, Mark Silberman, Jerzy Morkowski, Edward M Pina, Daniel C Mills, Christopher M Bates, Winston B Magno, Aliyah R Sohani, Beth A Sieling, Joseph M O'Donoghue, Chris M Bacon, Neill Patani, Despina Televantou, Suzanne D Turner, Laura Johnson, Fiona MacNeill, Andrew C Wotherspoon, Swaminathan P Iyer, Luis E Malpica, Keyur P Patel, Jie Xu, Roberto N Miranda
Jun 21, 2021
Breast implant anaplastic large cell lymphoma (ALCL) is a T-cell neoplasm arising around textured breast implants that was recognized recently as a distinct entity by the World Health Organization. Rarely, other types of...
Identification of Recurrent Mutations in the microRNA-Binding Sites of B-Cell Lymphoma-Associated Genes in Follicular Lymphoma.
Erika Larrea, Marta Fernandez-Mercado, José Afonso Guerra-Assunção, Jun Wang, Ibai Goicoechea, Ayman Gaafar, Izaskun Ceberio, Carmen Lobo, Jessica Okosun, Anton J Enright, Jude Fitzgibbon, Charles H Lawrie
Feb 08, 2021
Follicular lymphoma (FL) is a common indolent B-cell lymphoma that can transform into the more aggressive transformed FL (tFL). However, the molecular process driving this transformation is uncertain. In this work, we aimed to...
diffuse large B-cell lymphoma (DLBCL) follicular lymphoma (FL) microRNA Mutation Binding Sites Cell Line Tumor Cohort Studies Enhancer of Zeste Homolog 2 Protein Humans London Lymphoma Follicular Lymphoma Large B-Cell Diffuse MicroRNAs Mutation Proto-Oncogene Proteins c-bcl-2 Retrospective Studies Spain
SGK1 mutations in DLBCL generate hyperstable protein neoisoforms that promote AKT independence.
Jie Gao, Eirini Sidiropoulou, Ieuan Walker, Joanna A Krupka, Karol Mizielinski, Zelvera Usheva, Shamith A Samarajiwa, Daniel J Hodson
May 21, 2021
Serum and glucocorticoid-regulated kinase 1 (SGK1) is one of the most frequently mutated genes in diffuse large B-cell lymphoma (DLBCL). However, little is known about its function or the consequence of its mutation. The...
Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma.
Roland Schmitz, George W Wright, Da Wei Huang, Calvin A Johnson, James D Phelan, James Q Wang, Sandrine Roulland, Monica Kasbekar, Ryan M Young, Arthur L Shaffer, Daniel J Hodson, Wenming Xiao, Xin Yu, Yandan Yang, Hong Zhao, Weihong Xu, Xuelu Liu, Bin Zhou, Wei Du, Wing C Chan, Elaine S Jaffe, Randy D Gascoyne, Joseph M Connors, Elias Campo, Armando Lopez-Guillermo, Andreas Rosenwald, German Ott, Jan Delabie, Lisa M Rimsza, Kevin Tay Kuang Wei, Andrew D Zelenetz, John P Leonard, Nancy L Bartlett, Bao Tran, Jyoti Shetty, Yongmei Zhao, Dan R Soppet, Stefania Pittaluga, Wyndham H Wilson, Louis M Staudt
Jun 12, 2018
Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2.
Daniel J Hodson, Arthur L Shaffer, Wenming Xiao, George W Wright, Roland Schmitz, James D Phelan, Yandan Yang, Daniel E Webster, Lixin Rui, Holger Kohlhammer, Masao Nakagawa, Thomas A Waldmann, Louis M Staudt
Mar 01, 2016
Genetic Profiling in Diffuse Large B-Cell Lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. Over the previous 2 decades, tremendous progress has been made in our understanding of the molecular pathogenesis of DLBCL. However, this biological...
Molecular High-Grade B-Cell Lymphoma
Chulin Sha, Sharon Barrans, Francesco Cucco, Michael A Bentley, Matthew A Care, Thomas Cummin, Hannah Kennedy, Joe S Thompson, Rahman Uddin, Lisa Worrillow, Rebecca Chalkley, Moniek van Hoppe, Sophia Ahmed, Tom Maishman, Josh Caddy, Anna Schuh, Christoph Mamot, Catherine Burton, Reuben Tooze, Andrew Davies, Ming-Qing Du, Peter WM Johnson, David R Westhead
Feb 01, 2019
Antibodies Monoclonal Murine-Derived Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Bortezomib cyclophosphamide Databases Genetic Doxorubicin Female Humans Lymphoma Large B-Cell Diffuse Male Middle Aged Neoplasm Grading prednisone Proportional Hazards Models Randomized Controlled Trials as Topic Retrospective Studies Rituximab Transcriptome Vincristine
Gene-expression profiling of bortezomib added to standard chemoimmunotherapy for diffuse large B-cell lymphoma (REMoDL-B)
Andrew Davies, Thomas E Cummin, Sharon Barrans, Tom Maishman, Christoph Mamot, Urban Novak, Josh Caddy, Louise Stanton, Shamim Kazmi-Stokes, Andrew McMillan, Paul Fields, Christopher Pocock, Graham P Collins, Richard Stephens, Francesco Cucco, Alexandra Clipson, Chulin Sha, Reuben Tooze, Matthew A Care, Gareth Griffiths, Ming-Qing Du, David R Westhead, Catherine Burton, Peter WM Johnson
Apr 12, 2019
Adult Aged Aged 80 and over Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Bortezomib cyclophosphamide Disease Progression Doxorubicin Female Gene Expression Profiling Humans Lymphoma Large B-Cell Diffuse Male Middle Aged prednisone Progression-Free Survival Proteasome Inhibitors Rituximab Switzerland Time Factors Transcriptome United Kingdom Vincristine Young Adult
FOXP2-positive diffuse large B-cell lymphomas exhibit a poor response to R-CHOP therapy and distinct biological signatures.
Kah Keng Wong, Duncan M Gascoyne, Elizabeth J Soilleux, Linden Lyne, Hayley Spearman, Giovanna Roncador, Lars M Pedersen, Michael B Møller, Tina M Green, Alison H Banham
Dec 17, 2018
FOXP2 shares partially overlapping normal tissue expression and functionality with FOXP1; an established diffuse large B-cell lymphoma (DLBCL) oncogene and marker of poor prognosis. FOXP2 is expressed in the plasma cell...
FOXP2 diffuse large B-cell lymphoma survival Adult Aged Aged 80 and over Antibodies Monoclonal Murine-Derived Antineoplastic Combined Chemotherapy Protocols Cell Line Tumor cyclophosphamide Doxorubicin Female Forkhead Transcription Factors Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Ontology Humans Kaplan-Meier Estimate Lymphoma Large B-Cell Diffuse Male Middle Aged prednisone Protein Binding Repressor Proteins Signal Transduction Transcriptome Vincristine Young Adult
FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas.
PJ Brown, KK Wong, SL Felce, L Lyne, H Spearman, EJ Soilleux, LM Pedersen, MB Møller, TM Green, DM Gascoyne, AH Banham
Dec 17, 2018
The FOXP1 (forkhead box P1) transcription factor is a marker of poor prognosis in diffuse large B-cell lymphoma (DLBCL). Here microarray analysis of FOXP1-silenced DLBCL cell lines identified differential regulation of immune...
Adult Aged Aged 80 and over Antibodies Monoclonal Murine-Derived Antigens Differentiation B-Lymphocyte Antineoplastic Combined Chemotherapy Protocols B-Lymphocytes cyclophosphamide Doxorubicin Female Forkhead Transcription Factors Gene Expression Regulation Neoplastic Germinal Center HLA-DR alpha-Chains Histocompatibility Antigens Class II Humans Lymphocyte Activation Lymphoma Large B-Cell Diffuse Male Middle Aged Neoplasm Staging Nuclear Proteins prednisone RNA Small Interfering Repressor Proteins Rituximab Signal Transduction Survival Analysis Trans-Activators Vincristine
Genetic modification of primary human B cells to model high-grade lymphoma.
Rebecca Caeser, Miriam Di Re, Joanna A Krupka, Jie Gao, Maribel Lara-Chica, João ML Dias, Susanna L Cooke, Rachel Fenner, Zelvera Usheva, Hendrik FP Runge, Philip A Beer, Hesham Eldaly, Hyo-Kyung Pak, Chan-Sik Park, George S Vassiliou, Brian JP Huntly, Annalisa Mupo, Rachael JM Bashford-Rogers, Daniel J Hodson
Sep 13, 2019
Animals B-Lymphocytes CRISPR-Cas Systems Cell Line Tumor Cell Proliferation Coculture Techniques Genetic Vectors Germinal Center High-Throughput Screening Assays Humans Lymphoma Large B-Cell Diffuse Mice Neoplasm Grading Primary Cell Culture Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-bcl-6 Proto-Oncogene Proteins c-myc Retroviridae Transduction Genetic Xenograft Model Antitumor Assays
Targeted sequencing in DLBCL, molecular subtypes, and outcomes
Stuart E Lacy, Sharon L Barrans, Philip A Beer, Daniel Painter, Alexandra G Smith, Eve Roman, Susanna L Cooke, Camilo Ruiz, Paul Glover, Suzan JL Van Hoppe, Nichola Webster, Peter J Campbell, Reuben M Tooze, Russell Patmore, Cathy Burton, Simon Crouch, Daniel J Hodson
Feb 18, 2020
Adolescent Adult Aged Aged 80 and over Biomedical Research Child Child Preschool Cohort Studies Community Networks DNA Mutational Analysis Female Gene Expression Profiling Gene Expression Regulation Neoplastic Hematologic Neoplasms Humans Infant Lymphoma Large B-Cell Diffuse Male Medical Oncology Middle Aged Molecular Diagnostic Techniques Neoplasm Staging Prognosis Transcriptome United Kingdom Exome Sequencing Young Adult
Application of the LymphGen classification tool to 928 clinically and genetically-characterised cases of diffuse large B cell lymphoma (DLBCL).
Hendrik FP Runge, Stuart Lacy, Sharon Barrans, Philip A Beer, Daniel Painter, Alexandra Smith, Eve Roman, Cathy Burton, Simon Crouch, Reuben Tooze, Daniel J Hodson
Sep 09, 2020