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Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations
E Wheeler, A Leong, C-T Liu, M-F Hivert, RJ Strawbridge, C Podmore, M Li, J Yao, X Sim, J Hong, AY Chu, W Zhang, X Wang, P Chen, NM Maruthur, BC Porneala, SJ Sharp, Y Jia, EK Kabagambe, L-C Chang, W-M Chen, CE Elks, DS Evans, Q Fan, F Giulianini, MJ Go, J-J Hottenga, Y Hu, AU Jackson, S Kanoni, YJ Kim, ME Kleber, C Ladenvall, C Lecoeur, S-H Lim, Y Lu, A Mahajan, C Marzi, MA Nalls, P Navarro, IM Nolte, LM Rose, DV Rybin, S Sanna, Y Shi, DO Stram, F Takeuchi, SP Tan, PJ van der Most, JV Van Vliet-Ostaptchouk, A Wong, L Yengo, W Zhao, A Goel, MT Martinez Larrad, D Radke, P Salo, T Tanaka, EPA van Iperen, G Abecasis, S Afaq, BZ Alizadeh, AG Bertoni, A Bonnefond, Y Böttcher, EP Bottinger, H Campbell, OD Carlson, C-H Chen, YS Cho, WT Garvey, C Gieger, MO Goodarzi, H Grallert, A Hamsten, CA Hartman, C Herder, CA Hsiung, J Huang, M Igase, M Isono, T Katsuya, C-C Khor, W Kiess, K Kohara, P Kovacs, J Lee, W-J Lee, B Lehne, H Li, J Liu, S Lobbens, J Luan, V Lyssenko, T Meitinger, T Miki, I Miljkovic, S Moon, A Mulas, G Müller, M Müller-Nurasyid, R Nagaraja, M Nauck, JS Pankow, O Polasek, I Prokopenko, PS Ramos, L Rasmussen-Torvik, W Rathmann, SS Rich, NR Robertson, M Roden, R Roussel, I Rudan, RA Scott, WR Scott, B Sennblad, DS Siscovick, K Strauch, L Sun, M Swertz, SM Tajuddin, KD Taylor, Y-Y Teo, YC Tham, A Tönjes, NJ Wareham, G Willemsen, T Wilsgaard, AD Hingorani, EPIC-CVD Consortium, EPIC-InterAct Consortium, Lifelines Cohort Study, J Egan, L Ferrucci, GK Hovingh, A Jula, M Kivimaki, M Kumari, I Njølstad, CNA Palmer, M Serrano Ríos, M Stumvoll, H Watkins, T Aung, M Blüher, M Boehnke, DI Boomsma, SR Bornstein, JC Chambers, DI Chasman, Y-DI Chen, Y-T Chen, C-Y Cheng, F Cucca, EJC de Geus, P Deloukas, MK Evans, M Fornage, Y Friedlander, P Froguel, L Groop, MD Gross, TB Harris, C Hayward, C-K Heng, E Ingelsson, N Kato, B-J Kim, W-P Koh, JS Kooner, A Körner, D Kuh, J Kuusisto, M Laakso, X Lin, Y Liu, RJF Loos, PKE Magnusson, W März, MI McCarthy, AJ Oldehinkel, KK Ong, NL Pedersen, MA Pereira, A Peters, PM Ridker, C Sabanayagam, M Sale, D Saleheen, J Saltevo, PE Schwarz, WHH Sheu, H Snieder, TD Spector, Y Tabara, J Tuomilehto, RM van Dam, JG Wilson, JF Wilson, BHR Wolffenbuttel, TY Wong, J-Y Wu, J-M Yuan, AB Zonderman, N Soranzo, X Guo, DJ Roberts, JC Florez, R Sladek, J Dupuis, AP Morris, E-S Tai, E Selvin, JI Rotter, C Langenberg, I Barroso, JB Meigs
Oct 03, 2017
BACKGROUND: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic...
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