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Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2.
Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D Upton, Sonja Loges, Nicholas W Morrell, Werner Seeger, Ralph T Schermuly
Jan 28, 2022
Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e., monocrotaline and...
Sex-Specific Differences in Lysine, 3-Hydroxybutyric Acid and Acetic Acid in Offspring Exposed to Maternal and Postnatal High Linoleic Acid Diet, Independent of Diet.
Nirajan Shrestha, Steven D Melvin, Daniel R McKeating, Olivia J Holland, James SM Cuffe, Anthony V Perkins, Andrew J McAinch, Deanne H Hryciw
Sep 25, 2021
BACKGROUND: Linoleic acid (LA) is an essential polyunsaturated fatty acid (PUFA) that is required for foetal growth and development. Excess intake of LA can be detrimental for metabolic health due to its pro-inflammatory...
Linoleic Acid metabolite Offspring sex 3-Hydroxybutyric Acid Acetic Acid Adult Children Animals Animals Newborn Diet Diet High-Fat Female Lactation Linoleic Acid Lysine Male Maternal Nutritional Physiological Phenomena Plasma Pregnancy prenatal exposure delayed effects principal component analysis ROC Curve Rats Inbred WKY Sex Characteristics