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Nanobodies mapped to cross-reactive and divergent epitopes on A(H7N9) influenza hemagglutinin using yeast display.
Tiziano Gaiotto, Walter Ramage, Christina Ball, Paul Risley, George W Carnell, Nigel Temperton, Othmar G Engelhardt, Simon E Hufton
Aug 16, 2022
Influenza H7N9 virus continues to cause infections in humans and represents a significant pandemic risk. During the most recent 5th epidemic wave in 2016/17 two distinct lineages with increased human infections and wider...
Amino Acid Sequence Animals Antibodies Neutralizing Antibodies Viral Binding Sites Birds Epitopes Hemagglutinin Glycoproteins Influenza Virus Humans Influenza A virus H7N9 Subtype Influenza in Birds Influenza Human Models Molecular Peptide Library Protein Binding Protein Conformation Protein Interaction Domains and Motifs Saccharomyces cerevisiae Single-Domain Antibodies
Circulation of reassortant influenza A(H7N9) viruses in poultry and humans, Guangdong Province, China, 2013.
Changwen Ke, Jing Lu, Jie Wu, Dawei Guan, Lirong Zou, Tie Song, Lina Yi, Xianqiao Zeng, Lijun Liang, Hanzhong Ni, Min Kang, Xin Zhang, Haojie Zhong, Jianfeng He, Jinyan Lin, Derek Smith, David Burke, Ron AM Fouchier, Marion Koopmans, Yonghui Zhang
Nov 13, 2014
Adolescent Adult Aged Animals China Environmental Monitoring Female Genome Viral Geography Medical Hemagglutinin Glycoproteins Influenza Virus High-Throughput Nucleotide Sequencing Humans Influenza A virus H7N9 Subtype Influenza in Birds Influenza Human Male Middle Aged Neuraminidase Phylogeny Phylogeography Poultry Public Health Surveillance Reassortant Viruses Viral Proteins Young Adult
Nomenclature updates resulting from the evolution of avian influenza A(H5) virus clades 2.1.3.2a, 2.2.1, and 2.3.4 during 2013-2014.
Gavin JD Smith, Ruben O Donis, World Health Organization/World Organisation for Animal Health/Food and Agriculture Organization (WHO/OIE/FAO) H5 Evolution Working Group
Jun 24, 2015
H5 subtype clade nomenclature hemagglutinin highly pathogenic avian influenza molecular epidemiology phylogenetics Viral evolution Animals Biological Evolution Birds Hemagglutinin Glycoproteins Influenza Virus Humans Influenza A virus Influenza in Birds Influenza Human Molecular Sequence Data Phylogeny Poultry Diseases
Fitness Inference from Short-Read Data
Christopher JR Illingworth
Jul 30, 2015
fitness landscape Influenza Linkage Disequilibrium selection within-host evolution Adaptation Physiological Alleles Animals Biological Evolution evolution Molecular Ferrets Genetic Fitness Hemagglutinin Glycoproteins Influenza Virus Humans Influenza A virus H5N1 Subtype Influenza Human Linkage Disequilibrium Models Genetic Orthomyxoviridae Infections Reassortant Viruses selection Genetic
A latex agglutination assay to quantify the amount of hemagglutinin protein in adjuvanted low-dose influenza monovalent vaccines.
Sophie Buffin, Nabila Ikhelef, Julien Prudent, Joseline Dubayle, Nolwenn Nougarede, Marie-Pierre Varenne, Catherine Moste, Isabelle Legastelois
Mar 22, 2018
To formulate inactivated influenza vaccines, the concentration of hemagglutinin (HA) must be accurately determined. The standard test currently used to measure HA in influenza vaccines is the Single Radial Immunodiffusion (SRID)...
Epistatic interactions can moderate the antigenic effect of substitutions in haemagglutinin of influenza H3N2 virus.
Björn F Koel, David F Burke, Stefan van der Vliet, Theo M Bestebroer, Guus F Rimmelzwaan, Albert DME Osterhaus, Derek J Smith, Ron AM Fouchier
May 13, 2019
We previously showed that single amino acid substitutions at seven positions in haemagglutinin determined major antigenic change of influenza H3N2 virus. Here, the impact of two such substitutions was tested in 11 representative...
Antigenic variation of clade 2.1 H5N1 virus is determined by a few amino acid substitutions immediately adjacent to the receptor binding site.
Björn F Koel, Stefan van der Vliet, David F Burke, Theo M Bestebroer, Eny E Bharoto, I Wayan W Yasa, Inna Herliana, Brigitta M Laksono, Kemin Xu, Eugene Skepner, Colin A Russell, Guus F Rimmelzwaan, Daniel R Perez, Albert DME Osterhaus, Derek J Smith, Teguh Y Prajitno, Ron AM Fouchier
Mar 16, 2015
Genetic and antigenic characterisation of influenza A(H3N2) viruses isolated in Yokohama during the 2016/17 and 2017/18 influenza seasons.
Chiharu Kawakami, Seiya Yamayoshi, Miki Akimoto, Kazuya Nakamura, Hideka Miura, Seiichiro Fujisaki, David J Pattinson, Kohei Shimizu, Hiroki Ozawa, Tomoko Momoki, Miwako Saikusa, Atsuhiro Yasuhara, Shuzo Usuku, Ichiro Okubo, Takahiro Toyozawa, Shigeo Sugita, Derek J Smith, Shinji Watanabe, Yoshihiro Kawaoka
Feb 23, 2019
BACKGROUND: Influenza A(H3N2) virus rapidly evolves to evade human immune responses, resulting in changes in the antigenicity of haemagglutinin (HA). Therefore, continuous genetic and antigenic analyses of A(H3N2) virus are...
H3N2 HA Japan antigenicity EPIDEMIOLOGY Glycosylation haemagglutinin Influenza Influenza virus SURVEILLANCE viral infections Epidemics genetic variation Hemagglutinin Glycoproteins Influenza Virus Hemagglutinins Humans Influenza A virus H3N2 Subtype Influenza Human Japan Molecular Sequence Data Phylogeny RNA Viral Reverse Transcriptase Polymerase Chain Reaction Seasons Sequence Analysis DNA
Limited airborne transmission of H7N9 influenza A virus between ferrets.
Mathilde Richard, Eefje JA Schrauwen, Miranda de Graaf, Theo M Bestebroer, Monique IJ Spronken, Sander van Boheemen, Dennis de Meulder, Pascal Lexmond, Martin Linster, Sander Herfst, Derek J Smith, Judith M van den Brand, David F Burke, Thijs Kuiken, Guus F Rimmelzwaan, Albert DME Osterhaus, Ron AM Fouchier
Jun 12, 2020
Wild waterfowl form the main reservoir of influenza A viruses, from which transmission occurs directly or indirectly to various secondary hosts, including humans. Direct avian-to-human transmission has been observed for viruses...
Amino Acid Substitutions That Affect Receptor Binding and Stability of the Hemagglutinin of Influenza A/H7N9 Virus.
Eefje JA Schrauwen, Mathilde Richard, David F Burke, Guus F Rimmelzwaan, Sander Herfst, Ron AM Fouchier
Mar 14, 2016
Selection of antigenically advanced variants of seasonal influenza viruses.
Chengjun Li, Masato Hatta, David F Burke, Jihui Ping, Ying Zhang, Makoto Ozawa, Andrew S Taft, Subash C Das, Anthony P Hanson, Jiasheng Song, Masaki Imai, Peter R Wilker, Tokiko Watanabe, Shinji Watanabe, Mutsumi Ito, Kiyoko Iwatsuki-Horimoto, Colin A Russell, Sarah L James, Eugene Skepner, Eileen A Maher, Gabriele Neumann, Alexander I Klimov, Anne Kelso, John McCauley, Dayan Wang, Yuelong Shu, Takato Odagiri, Masato Tashiro, Xiyan Xu, David E Wentworth, Jacqueline M Katz, Nancy J Cox, Derek J Smith, Yoshihiro Kawaoka
Apr 13, 2016
Characterization of co-circulating swine influenza A viruses in North America and the identification of a novel H1 genetic clade with antigenic significance.
Tavis K Anderson, Brian A Campbell, Martha I Nelson, Nicola S Lewis, Alicia Janas-Martindale, Mary Lea Killian, Amy L Vincent
Jun 02, 2015
Antigenic drift EPIDEMIOLOGY Influenza A virus Swine vaccines Zoonotic diseases Animals Cluster Analysis genetic variation Genotype Hemagglutinin Glycoproteins Influenza Virus Influenza A virus molecular epidemiology North America Orthomyxoviridae Infections Phylogeny RNA Viral Sequence Analysis DNA Sequence Homology Swine Swine Diseases
Antigenic characterization of highly pathogenic avian influenza A(H5N1) viruses with chicken and ferret antisera reveals clade-dependent variation in hemagglutination inhibition profiles.
Diep Thi Nguyen, Samuel S Shepard, David Francis Burke, Joyce Jones, Sharmi Thor, Long Van Nguyen, Tho Dang Nguyen, Amanda Balish, Dang Nguyen Hoang, Thanh Long To, Munir Iqbal, David E Wentworth, Erica Spackman, H Rogier van Doorn, C Todd Davis, Juliet E Bryant
Oct 10, 2018
Highly pathogenic avian influenza (HPAI) A(H5N1) viruses pose a significant economic burden to the poultry industry worldwide and have pandemic potential. Poultry vaccination against HPAI A(H5N1) viruses has been an important...
Identification of amino acid substitutions supporting antigenic change of influenza A(H1N1)pdm09 viruses.
Björn F Koel, Ramona Mögling, Salin Chutinimitkul, Pieter L Fraaij, David F Burke, Stefan van der Vliet, Emmie de Wit, Theo M Bestebroer, Guus F Rimmelzwaan, Albert DME Osterhaus, Derek J Smith, Ron AM Fouchier, Miranda de Graaf
May 28, 2015
The Molecular Basis for Antigenic Drift of Human A/H2N2 Influenza Viruses.
M Linster, EJA Schrauwen, S van der Vliet, DF Burke, P Lexmond, TM Bestebroer, DJ Smith, S Herfst, BF Koel, RAM Fouchier
Feb 23, 2019
Influenza A/H2N2 viruses caused a pandemic in 1957 and continued to circulate in humans until 1968. The antigenic evolution of A/H2N2 viruses over time and the amino acid substitutions responsible for this antigenic evolution...
antigenic evolution influenza virus A/H2N2 molecular drift pandemic Amino Acid Substitution Animals Antigens Viral Dogs evolution Molecular Ferrets Hemagglutinin Glycoproteins Influenza Virus Humans Influenza A virus H2N2 Subtype Influenza Human Madin Darby Canine Kidney Cells Mutation Missense Pandemics Time Factors
Development of Lentiviral Vectors Pseudotyped With Influenza B Hemagglutinins
Francesca Ferrara, Joanne Marie M Del Rosario, Kelly AS da Costa, Rebecca Kinsley, Simon Scott, Sasan Fereidouni, Craig Thompson, Paul Kellam, Sarah Gilbert, George Carnell, Nigel Temperton
Jul 29, 2021
Influenza B viruses (IBV) cause respiratory disease epidemics in humans and are therefore components of seasonal influenza vaccines. Serological methods are employed to evaluate vaccine immunogenicity prior to licensure....
Influenza B lentiviral (LV) vector pseudotype neutralization pseudotype viral particles serosurveillance A549 Cells Animals Antibodies Monoclonal Antibodies Neutralizing Antibodies Viral Antibody Specificity Dogs Genetic Vectors HEK293 Cells Hemagglutinin Glycoproteins Influenza Virus Humans Immunogenicity Vaccine Influenza B virus Influenza Vaccines Influenza Human Lentivirus Madin Darby Canine Kidney Cells Neutralization Tests Orthomyxoviridae Infections Vaccination Vaccine Potency