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Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance.
Dominik Aschenbrenner, Maria Quaranta, Soumya Banerjee, Nicholas Ilott, Joanneke Jansen, Boyd Steere, Yin-Huai Chen, Stephen Ho, Karen Cox, Carolina V Arancibia-Cárcamo, Mark Coles, Eamonn Gaffney, Simon PL Travis, Lee Denson, Subra Kugathasan, Jochen Schmitz, Fiona Powrie, Stephen N Sansom, Holm H Uhlig
Jul 01, 2021
OBJECTIVE: Dysregulated immune responses are the cause of IBDs. Studies in mice and humans suggest a central role of interleukin (IL)-23-producing mononuclear phagocytes in disease pathogenesis. Mechanistic insights into the...
inflammatory bowel disease Interleukins Mucosal immunology Adolescent Adult Aged Aged 80 and over Autocrine Communication Cells Cultured Drug Resistance Female Gene Expression Gene Expression Regulation Gene Regulatory Networks Homeostasis Humans Inflammatory Bowel Diseases Interleukin-10 Interleukin-1alpha Interleukin-1beta Interleukin-23 Subunit p19 Lipopolysaccharides Male Middle Aged Monocytes Paracrine Communication Receptors Interleukin-10 Signal Transduction Transcriptome Tumor Necrosis Factor-alpha Young Adult
Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection.
María A Duque-Correa, Natasha A Karp, Catherine McCarthy, Simon Forman, David Goulding, Geetha Sankaranarayanan, Timothy P Jenkins, Adam J Reid, Emma L Cambridge, Carmen Ballesteros Reviriego, Sanger Mouse Genetics Project, 3i consortium, Werner Müller, Cinzia Cantacessi, Gordon Dougan, Richard K Grencis, Matthew Berriman
Jan 21, 2019
The whipworm Trichuris trichiura is a soil-transmitted helminth that dwells in the epithelium of the caecum and proximal colon of their hosts causing the human disease, trichuriasis. Trichuriasis is characterized by colitis...
Molecular modelling of the HCMV IL-10 protein isoforms and analysis of their interaction with the human IL-10 receptor.
Simone Queiroz Pantaleão, Lívia de Moraes Bomediano Camillo, Tainan Cerqueira Neves, Isabela de Godoy Menezes, Lucas Matheus Stangherlin, Helena Beatriz de Carvalho Ruthner Batista, Emma Poole, Michael Nevels, Eric Alisson Philot, Ana Ligia Scott, Maria Cristina Carlan da Silva
Jan 04, 2023
The human cytomegalovirus (HCMV) UL111A gene encodes several homologs of the cellular interleukin 10 (cIL-10). Alternative splicing in the UL111A region produces two relatively well-characterized transcripts designated cmvIL-10...