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Association between a functional interleukin 6 receptor genetic variant and risk of depression and psychosis in a population-based birth cohort.
OBJECTIVE: Interleukin 6 (IL-6) levels are commonly elevated in patients with depression and psychosis and in people who are at risk of developing these disorders. A common, functional variant in the IL6R gene (IL6R Asp358Ala;...
ALSPAC birth cohort Asp358Ala Depression IL-6 IL6R immunopsychiatry Inflammation interleukin 6 interleukin 6 receptor Interleukin 6 receptor gene Mendelian randomization Psychosis rs2228145 Adolescent C-Reactive Protein Child Cohort Studies Depressive Disorder Female Genetic Predisposition to Disease Genotype Humans Interleukin-6 Male Polymorphism Single Nucleotide Psychotic Disorders Receptors Interleukin-6
Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.
REMAP-CAP Investigators, Anthony C Gordon, Paul R Mouncey, Farah Al-Beidh, Kathryn M Rowan, Alistair D Nichol, Yaseen M Arabi, Djillali Annane, Abi Beane, Wilma van Bentum-Puijk, Lindsay R Berry, Zahra Bhimani, Marc JM Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Adrian Buzgau, Allen C Cheng, Michelle A Detry, Eamon J Duffy, Lise J Estcourt, Mark Fitzgerald, Herman Goossens, Rashan Haniffa, Alisa M Higgins, Thomas E Hills, Christopher M Horvat, Francois Lamontagne, Patrick R Lawler, Helen L Leavis, Kelsey M Linstrum, Edward Litton, Elizabeth Lorenzi, John C Marshall, Florian B Mayr, Daniel F McAuley, Anna McGlothlin, Shay P McGuinness, Bryan J McVerry, Stephanie K Montgomery, Susan C Morpeth, Srinivas Murthy, Katrina Orr, Rachael L Parke, Jane C Parker, Asad E Patanwala, Ville Pettilä, Emma Rademaker, Marlene S Santos, Christina T Saunders, Christopher W Seymour, Manu Shankar-Hari, Wendy I Sligl, Alexis F Turgeon, Anne M Turner, Frank L van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J Lewis, Derek C Angus, Colin J McArthur, Scott Berry, Steve A Webb, Lennie PG Derde
Oct 04, 2021
BACKGROUND: The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. METHODS: We evaluated tocilizumab and sarilumab in an ongoing international...
Genetically proxied interleukin-6 receptor inhibition
Respiratory disease is a main feature of severe COVID-19, and the potential of IL-6 receptor blockade to increase risk of pneumonia warrants vigilance and caution in its application to treat COVID-19 https://bit.ly/34Y8Ner
Protocol for the insight study
Golam M Khandaker, Bianca P Oltean, Muzaffer Kaser, Claire RM Dibben, Rajini Ramana, Deepak R Jadon, Robert Dantzer, Alasdair J Coles, Glyn Lewis, Peter B Jones
Oct 03, 2018
INTRODUCTION: Observational studies indicate a potentially causal role for interleukin 6 (IL-6), a proinflammatory cytokine, in pathogenesis of depression, but interventional studies based on patients with depression have not...
Clinical Trials Antibodies Monoclonal Humanized Biomarkers C-Reactive Protein Cognition Depressive Disorder Double-Blind Method Humans Inflammation Infusions Intravenous Proof of Concept Study Psychiatric Status Rating Scales Randomized Controlled Trials as Topic Receptors Interleukin-6 Treatment Outcome
Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates.
Ellie Paige, Marc Clément, Fabien Lareyre, Michael Sweeting, Juliette Raffort, Céline Grenier, Alison Finigan, James Harrison, James E Peters, Benjamin B Sun, Adam S Butterworth, Seamus C Harrison, Matthew J Bown, Jes S Lindholt, Stephen A Badger, Iftikhar J Kullo, Janet Powell, Paul E Norman, D Julian A Scott, Marc A Bailey, Stefan Rose-John, John Danesh, Daniel F Freitag, Dirk S Paul, Ziad Mallat
Feb 07, 2019
BACKGROUND: The Asp358Ala variant (rs2228145; A>C) in the IL (interleukin)-6 receptor ( IL6R) gene has been implicated in the development of abdominal aortic aneurysms (AAAs), but its effect on AAA growth over time is not known....
Alleles Aortic Aneurysm Genetics Inflammation Interleukins Alleles Angiotensin II Animals Antibodies Aortic Aneurysm Abdominal Biomarkers Disease Models Animal Humans Interleukin-6 Linear Models Mice Polymorphism Single Nucleotide Receptors Interleukin-6 Signal Transduction Survival Rate Transforming Growth Factor beta
Meta-analysis investigating the role of interleukin-6 mediated inflammation in type 2 diabetes.
Nicholas Bowker, Rupal L Shah, Stephen J Sharp, Jian'an Luan, Isobel D Stewart, Eleanor Wheeler, Manuel AR Ferreira, Aris Baras, Nicholas J Wareham, Claudia Langenberg, Luca A Lotta
Oct 07, 2020
Genetic Interleukin-6 Trans-ethnic Type 2 diabetes Adiposity Biomarkers Blood Glucose Body Weights and Measures Cytokines Diabetes mellitus Type 2 Disease Susceptibility Genetic Predisposition to Disease Humans Inflammation Inflammation Mediators Interleukin-6 Odds Ratio Receptors Interleukin-6 Risk Factors Signal Transduction
Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death
Fergus W Hamilton, Matt Thomas, David Arnold, Tom Palmer, Ed Moran, Alexander J Mentzer, Nick Maskell, Kenneth Baillie, Charlotte Summers, Aroon Hingorani, Alasdair MacGowan, Golam M Khandaker, Ruth Mitchell, George Davey Smith, Peter Ghazal, Nicholas J Timpson
Mar 02, 2023