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Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke.
Shereen Nizari, Marina Basalay, Philippa Chapman, Nils Korte, Alla Korsak, Isabel N Christie, Shefeeq M Theparambil, Sean M Davidson, Frank Reimann, Stefan Trapp, Derek M Yellon, Alexander V Gourine
Jan 28, 2022
Stroke remains one of the most common causes of death and disability worldwide. Several preclinical studies demonstrated that the brain can be effectively protected against ischaemic stroke by two seemingly distinct treatments...
Brain capillaries Brain arterioles cerebral blood flow Glucagon-like peptide-1 Ischaemic stroke Middle cerebral artery occlusion Neuroprotection Remote ischaemic preconditioning Animals Arterioles Cerebrovascular Circulation Disease Models Animal Glucagon-Like Peptide-1 Receptor Hindlimb Incretins Infarction Middle Cerebral artery Ischemic preconditioning ischemic stroke Male Neuroprotective Agents Peptide Fragments Rats Sprague-Dawley Regional Blood Flow Vasodilation Vasodilator Agents
Cerebral Edema in Middle Cerebral Artery Occlusion: A Study in Primates by Wet Weight
Aim: To verify whether there is any correlation between the microcirculatory perfusion impairment, area of infarction and cerebral edema after occlusion of MCA and find out whether there is any definite “reperfusion window”...
Published by: IJHS Medical Association
Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man.
Rhiannon S Morris, P Simon Jones, Josef A Alawneh, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, Elizabeth A Warburton, Jean-Claude Baron
Nov 06, 2018
Modern ischaemic stroke management involves intravenous thrombolysis followed by mechanical thrombectomy, which allows markedly higher rates of recanalization and penumbral salvage than thrombolysis alone. However, <50% of...
Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT(1A) agonist in rat models of ischaemic stroke.
Maria Ashioti, John S Beech, Andrew S Lowe, Michel Bernanos, Andrew McCreary, Michel M Modo, Steve CR Williams
Jun 13, 2011
Animals Cerebral Cortex Cytoprotection Dizocilpine Maleate Infarction Middle Cerebral artery Magnetic Resonance Imaging Male Neurons Neuropsychological Tests Outcome Assessment Health Care Rats Rats Inbred SHR Rats Sprague-Dawley Serotonin 5-HT1 Receptor Agonists Serotonin Receptor Agonists Time Factors
Cerebral Edema in Middle Cerebral Artery Occlusion: A Study in Primates by Wet Weight
Aim: To verify whether there is any correlation between the microcirculatory perfusion impairment, area of infarction and cerebral edema after occlusion of MCA and find out whether there is any definite “reperfusion window”...
Published by: IJHS Medical Association