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Ionic immune suppression within the tumour microenvironment limits T cell effector function.
Robert Eil, Suman K Vodnala, David Clever, Christopher A Klebanoff, Madhusudhanan Sukumar, Jenny H Pan, Douglas C Palmer, Alena Gros, Tori N Yamamoto, Shashank J Patel, Geoffrey C Guittard, Zhiya Yu, Valentina Carbonaro, Klaus Okkenhaug, David S Schrump, W Marston Linehan, Rahul Roychoudhuri, Nicholas P Restifo
Jun 27, 2018
Tumours progress despite being infiltrated by tumour-specific effector T cells. Tumours contain areas of cellular necrosis, which are associated with poor survival in a variety of cancers. Here, we show that necrosis releases...
Animals cations Monovalent Humans Immune Tolerance Immunotherapy Kv1.3 Potassium Channel Male Melanoma Membrane Potentials Mice Necrosis Potassium Proto-Oncogene Proteins c-akt Receptors Antigen T-Cell Signal Transduction Survival Analysis T-Lymphocytes TOR Serine-Threonine Kinases Tumor Escape Tumor Microenvironment
Monovalent Cation Doping of CH3NH3PbI3 for Efficient Perovskite Solar Cells.
Mojtaba Abdi-Jalebi, M Ibrahim Dar, Aditya Sadhanala, Satyaprasad P Senanayak, Michael Grätzel, Richard H Friend
Nov 01, 2016