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Performance of the ImmuView and BinaxNOW assays for the detection of urine and cerebrospinal fluid Streptococcus pneumoniae and Legionella pneumophila serogroup 1 antigen in patients with Legionnaires' disease or pneumococcal pneumonia and meningitis.
The performances of the ImmuView Streptococcus pneumoniae (Sp) and Legionella pneumophila (Lp) urinary antigen test were compared to that of the BinaxNOW Sp and Lp assays, using frozen urine from 166 patients with Legionnaires'...
Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children.
Kenyan Bacteraemia Study Group, Wellcome Trust Case Control Consortium 2 (WTCCC2), Anna Rautanen, Matti Pirinen, Tara C Mills, Kirk A Rockett, Amy Strange, Anne W Ndungu, Vivek Naranbhai, James J Gilchrist, Céline Bellenguez, Colin Freeman, Gavin Band, Suzannah J Bumpstead, Sarah Edkins, Eleni Giannoulatou, Emma Gray, Serge Dronov, Sarah E Hunt, Cordelia Langford, Richard D Pearson, Zhan Su, Damjan Vukcevic, Alex W Macharia, Sophie Uyoga, Carolyne Ndila, Neema Mturi, Patricia Njuguna, Shebe Mohammed, James A Berkley, Isaiah Mwangi, Salim Mwarumba, Barnes S Kitsao, Brett S Lowe, Susan C Morpeth, Iqbal Khandwalla, Kilifi Bacteraemia Surveillance Group, Jenefer M Blackwell, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden Corvin, Audrey Duncanson, Janusz Jankowski, Hugh S Markus, Christopher G Mathew, Colin NA Palmer, Robert Plomin, Stephen J Sawcer, Richard C Trembath, Ananth C Viswanathan, Nicholas W Wood, Panos Deloukas, Leena Peltonen, Thomas N Williams, J Anthony G Scott, Stephen J Chapman, Peter Donnelly, Adrian VS Hill, Chris CA Spencer
Jun 10, 2016
Large scale genomic analysis shows no evidence for pathogen adaptation between the blood and cerebrospinal fluid niches during bacterial meningitis.
John A Lees, Philip HC Kremer, Ana S Manso, Nicholas J Croucher, Bart Ferwerda, Mercedes Valls Serón, Marco R Oggioni, Julian Parkhill, Matthijs C Brouwer, Arie van der Ende, Diederik van de Beek, Stephen D Bentley
Sep 06, 2019
Recent studies have provided evidence for rapid pathogen genome diversification, some of which could potentially affect the course of disease. We have previously described such variation seen between isolates infecting the blood...
Neisseria meningitidis Streptococcus pneumoniae ivr locus Meningitis pan-genome calling within-host evolution Adaptation Biological Blood-Brain Barrier Carrier State DNA Bacterial genetic variation Humans Meningitis Meningococcal Meningitis Pneumococcal nasopharynx Neisseria meningitidis Streptococcus pneumoniae whole genome sequencing
Impact of infant 13-valent pneumococcal conjugate vaccine on serotypes in adult pneumonia.
Chamira Rodrigo, Thomas Bewick, Carmen Sheppard, Sonia Greenwood, Tricia M Mckeever, Caroline L Trotter, Mary Slack, Robert George, Wei Shen Lim
Mar 03, 2015
Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism.
Chrispin Chaguza, Marie Yang, Jennifer E Cornick, Mignon Du Plessis, Rebecca A Gladstone, Brenda A Kwambana-Adams, Stephanie W Lo, Chinelo Ebruke, Gerry Tonkin-Hill, Chikondi Peno, Madikay Senghore, Stephen K Obaro, Sani Ousmane, Gerd Pluschke, Jean-Marc Collard, Betuel Sigaùque, Neil French, Keith P Klugman, Robert S Heyderman, Lesley McGee, Martin Antonio, Robert F Breiman, Anne von Gottberg, Dean B Everett, Aras Kadioglu, Stephen D Bentley
Oct 08, 2021
Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against vaccine serotype pneumococcal pneumonia in adults
Hannah Lawrence, Harry Pick, Vadsala Baskaran, Priya Daniel, Chamira Rodrigo, Deborah Ashton, Rochelle C Edwards-Pritchard, Carmen Sheppard, Seyi D Eletu, David Litt, Norman K Fry, Samuel Rose, Caroline Trotter, Tricia M Mckeever, Wei Shen Lim
Nov 09, 2020
BACKGROUND: Vaccination with the 23-valent pneumococcal polysaccharide vaccine (PPV23) is available in the United Kingdom to adults aged 65 years or older and those in defined clinical risk groups. We evaluated the vaccine...
Adult Aged Aged 80 and over Case-Control Studies Community-Acquired Infections Female Hospitalization Humans Male Middle Aged Odds Ratio Pneumococcal Infections Pneumococcal Vaccines Pneumonia Pneumococcal Prospective Studies Serogroup Streptococcus pneumoniae United Kingdom Vaccination vaccines Conjugate
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis.
John A Lees, Bart Ferwerda, Philip HC Kremer, Nicole E Wheeler, Mercedes Valls Serón, Nicholas J Croucher, Rebecca A Gladstone, Hester J Bootsma, Nynke Y Rots, Alienke J Wijmega-Monsuur, Elisabeth AM Sanders, Krzysztof Trzciński, Anne L Wyllie, Aeilko H Zwinderman, Leonard H Van den Berg, Wouter Van Rheenen, Jan H Veldink, Zitta B Harboe, Lene F Lundbo, Lisette CPGM de Groot, Natasja M van Schoor, Nathalie van der Velde, Lars H Ängquist, Thorkild IA Sørensen, Ellen A Nohr, Alexander J Mentzer, Tara C Mills, Julian C Knight, Mignon Du Plessis, Susan Nzenze, Jeffrey N Weiser, Julian Parkhill, Shabir Madhi, Thomas Benfield, Anne von Gottberg, Arie van der Ende, Matthijs C Brouwer, Jeffrey C Barrett, Stephen D Bentley, Diederik van de Beek
Jul 25, 2019
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in...