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Results: 27
Treatment of psoriatic arthritis with biologic and targeted synthetic DMARDs
William Tillett, Alexander Allen, Laura Tucker, David Chandler, Coziana Ciurtin, Charlotte Davis, Andrew Dick, Amy Foulkes, Nicola Gullick, Philip Helliwell, Deepak Jadon, Gareth Jones, Stuart Kyle, Vishnu Madhok, Neil McHugh, Andrew Parkinson, Tim Raine, Stefan Siebert, Catherine Smith, Laura C Coates
Dec 03, 2020
The aim of this guideline is to provide an update on evidence-based recommendations for treatment of adult patients with PsA. The previous BSR guidelines for PsA were published in 2012 and since that time, there have been many...
On Modelling Minimal Disease Activity.
OBJECTIVE: To explore methods for statistical modelling of minimal disease activity (MDA) based on data from intermittent clinic visits. METHODS: The analysis was based on a 2-state model. Comparisons were made between analyses...
A multistate model for events defined by prolonged observation.
Time-to-event and similar analyses can be problematic if the event of interest is operationally defined by some condition being true for a prolonged period of time. A particular example of this, remission in psoriatic arthritis...
The versatility of multi-state models for the analysis of longitudinal data with unobservable features.
Multi-state models provide a convenient statistical framework for a wide variety of medical applications characterized by multiple events and longitudinal data. We illustrate this through four examples. The potential value of...
Axial involvement in psoriatic arthritis
Psoriatic arthritis (PsA) is a heterogenous, chronic, inflammatory musculoskeletal disease that can lead to peripheral and axial damage and loss of function. Axial involvement occurs in 25% to 70% of patients with PsA, varying...
Feasibility, reliability, and sensitivity to change of four radiographic scoring methods in patients with psoriatic arthritis
W Tillett, D Jadon, G Shaddick, G Robinson, R Sengupta, E Korendowych, C S de Vries, N J McHugh
Feb 01, 2014
Objective We set out to assess the feasibility, reliability, and sensitivity to change of 4 radiographic scoring methods in psoriatic arthritis (PsA). Methods Hand and feet radiographs from 50 patients with PsA were scored at 2...
Adult Analysis of Variance Arthritis Psoriatic Feasibility Studies Foot Joints Hand Joints Humans Middle Aged Observer Variation Predictive Value of Tests Radiography Reproducibility of Results Severity of Illness Index Time Factors Comparative Study Evaluation studies Journal Article Research support Non-U.S. Gov't
A randomized placebo-controlled trial of methotrexate in psoriatic arthritis.
Gabrielle H Kingsley, Anna Kowalczyk, Helen Taylor, Fowzia Ibrahim, Jonathan C Packham, Neil J McHugh, Diarmuid M Mulherin, George D Kitas, Kuntal Chakravarty, Brian DM Tom, Aidan G O'Keeffe, Peter J Maddison, David L Scott
Aug 07, 2018
OBJECTIVE: MTX is widely used to treat synovitis in PsA without supporting trial evidence. The aim of our study was to test the value of MTX in the first large randomized placebo-controlled trial (RCT) in PsA. METHODS: A 6-month...
Feasibility, reliability, and sensitivity to change of four radiographic scoring methods in patients with psoriatic arthritis
W Tillett, D Jadon, G Shaddick, G Robinson, R Sengupta, E Korendowych, C S de Vries, N J McHugh
Feb 01, 2014
Objective We set out to assess the feasibility, reliability, and sensitivity to change of 4 radiographic scoring methods in psoriatic arthritis (PsA). Methods Hand and feet radiographs from 50 patients with PsA were scored at 2...
Adult Analysis of Variance Arthritis Psoriatic Feasibility Studies Foot Joints Hand Joints Humans Middle Aged Observer Variation Predictive Value of Tests Radiography Reproducibility of Results Severity of Illness Index Time Factors Comparative Study Evaluation studies Journal Article Research support Non-U.S. Gov't
Proceedings of the 2020 GRAPPA Collaborative Research Network (CRN) Meeting.
Carmel Stober, Deepak R Jadon, April W Armstrong, Vinod Chandran, Maarten de Wit, Philip S Helliwell, Philip Mease, Alexis Ogdie, Denis O'Sullivan, Stephen R Pennington, Thorvardur Löve, Alberto Cauli, Leonieke van Mens, Robin Waxman, Jose U Scher, Anne Barton, Christopher T Ritchlin, Oliver FitzGerald
Mar 03, 2021
At the 2020 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)- Collaborative Research Network (CRN) annual meeting, the GRAPPA-CRN group presented a pilot investigator-initiated study protocol to...
Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)
Laura C Coates, Enrique R Soriano, Nadia Corp, Heidi Bertheussen, Kristina Callis Duffin, Cristiano B Campanholo, Jeffrey Chau, Lihi Eder, Daniel G Fernández-Ávila, Oliver FitzGerald, Amit Garg, Dafna D Gladman, Niti Goel, Philip S Helliwell, M Elaine Husni, Deepak R Jadon, Arnon Katz, Dhruvkumar Laheru, John Latella, Ying-Ying Leung, Christine Lindsay, Ennio Lubrano, Luis Daniel Mazzuoccolo, Philip J Mease, Denis O'Sullivan, Alexis Ogdie, Wendy Olsder, Penelope Esther Palominos, Lori Schick, Ingrid Steinkoenig, Maarten de Wit, DA van der Windt, Arthur Kavanaugh, GRAPPA Treatment Recommendations domain subcommittees
Jul 28, 2022
Since the second version of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations were published in 2015, therapeutic options for psoriatic arthritis (PsA) have advanced...
Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling.
Mehreen Soomro, Michael Stadler, Nick Dand, James Bluett, Deepak Jadon, Farideh Jalali-Najafabadi, Michael Duckworth, Pauline Ho, Helena Marzo-Ortega, Philip S Helliwell, Anthony W Ryan, David Kane, Eleanor Korendowych, Michael A Simpson, Jonathan Packham, Ross McManus, Cem Gabay, Céline Lamacchia, Michael J Nissen, Matthew A Brown, Suzanne MM Verstappen, Tjeerd Van Staa, Jonathan N Barker, Catherine H Smith, BADBIR Study Group, BSTOP Study Group, Oliver FitzGerald, Neil McHugh, Richard B Warren, John Bowes, Anne Barton
Aug 04, 2022
Application of information theoretic feature selection and machine learning methods for the development of genetic risk prediction models.
Farideh Jalali-Najafabadi, Michael Stadler, Nick Dand, Deepak Jadon, Mehreen Soomro, Pauline Ho, Helen Marzo-Ortega, Philip Helliwell, Eleanor Korendowych, Michael A Simpson, Jonathan Packham, Catherine H Smith, Jonathan N Barker, Neil McHugh, Richard B Warren, Anne Barton, John Bowes, BADBIR Study Group, BSTOP Study Group
Jan 28, 2022
In view of the growth of clinical risk prediction models using genetic data, there is an increasing need for studies that use appropriate methods to select the optimum number of features from a large number of genetic variants...
Proceedings of the 2019 GRAPPA Collaborative Research Network Meeting.
Robin Waxman, Carmel Stober, Deepak R Jadon, Ana-Maria Orbai, Vinod Chandran, Alexis Ogdie, Stephen R Pennington, Maarten de Wit, Denis O'Sullivan, Philip J Mease, April W Armstrong, Kristina Callis Duffin, Philip S Helliwell, Leonieke JJ van Mens, Christopher T Ritchlin, Oliver FitzGerald
Apr 06, 2020
At the 2019 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis-Collaborative Research Network annual meeting, the group presented its progress in selecting a database platform; items to include in an...
Mixture distributions in multi-state modelling
In many studies, interest lies in determining whether members of the study population will undergo a particular event of interest. Such scenarios are often termed 'mover-stayer' scenarios, and interest lies in modelling two...
Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis.
Frank Penkava, Martin Del Castillo Velasco-Herrera, Matthew D Young, Nicole Yager, Lilian N Nwosu, Arthur G Pratt, Alicia Lledo Lara, Charlotte Guzzo, Ash Maroof, Lira Mamanova, Suzanne Cole, Mirjana Efremova, Davide Simone, Andrew Filer, Chrysothemis C Brown, Andrew L Croxford, John D Isaacs, Sarah Teichmann, Paul Bowness, Sam Behjati, M Hussein Al-Mossawi
Oct 23, 2020
Synovial Membrane Synovial Fluid CD8-Positive T-Lymphocytes Humans Arthritis Psoriatic Receptors Lymphocyte Homing Receptors Chemokine Receptors Antigen T-Cell alpha-beta Gene Expression Profiling Immunologic Memory Single-Cell Analysis Clonal Selection Antigen-Mediated
Published by: Nature Communications
Bias in 2-part mixed models for longitudinal semicontinuous data.
Semicontinuous data in the form of a mixture of zeros and continuously distributed positive values frequently arise in biomedical research. Two-part mixed models with correlated random effects are an attractive approach to...
A joint modelling approach for multistate processes subject to resolution and under intermittent observations.
Multistate processes provide a convenient framework when interest lies in characterising the transition intensities between a set of defined states. If, however, there is an unobserved event of interest (not known if and when...
Trajectory of radiographic change over a decade
Andrew Allard, Anna Antony, Gavin Shaddick, Deepak R Jadon, Charlotte Cavill, Graham Robinson, Eleanor Korendowych, Neil McHugh, William Tillett
Feb 25, 2019
Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis.
Frank Penkava, Martin Del Castillo Velasco-Herrera, Matthew D Young, Nicole Yager, Lilian N Nwosu, Arthur G Pratt, Alicia Lledo Lara, Charlotte Guzzo, Ash Maroof, Lira Mamanova, Suzanne Cole, Mirjana Efremova, Davide Simone, Andrew Filer, Chrysothemis C Brown, Andrew L Croxford, John D Isaacs, Sarah Teichmann, Paul Bowness, Sam Behjati, M Hussein Al-Mossawi
Nov 20, 2020
Psoriatic arthritis (PsA) is a debilitating immune-mediated inflammatory arthritis of unknown pathogenesis commonly affecting patients with skin psoriasis. Here we use complementary single-cell approaches to study leukocytes...
Methods for observed-cluster inference when cluster size is informative
Treating to target in psoriatic arthritis
Ines Rombach, William Tillett, Deepak Jadon, Laura Tucker, Marion Watson, Anne Francis, Yvonne Sinomati, Lucy Eldridge, Melina Dritsaki, Susan J Dutton, Hussein Al-Mossawi, Nicola Gullick, Ben Thompson, Laura C Coates
Apr 12, 2021
BACKGROUND: The Tight Control of psoriatic arthritis (TICOPA) trial confirmed improved clinical outcomes with a treat to target (T2T) strategy in psoriatic arthritis (PsA). This consisted of 4-weekly review and escalation of...
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