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Results: 15
Oxidative stress and phosphatidylserine exposure in red cells from patients with sickle cell anaemia.
Nocturnal enuresis and K+ transport in red blood cells from patients with sickle cell anemia.
Cation Homeostasis in Red Cells From Patients With Sickle Cell Disease Heterologous for HbS and HbC (HbSC Genotype).
A gain of function variant in PIEZO1 (E756del) and sickle cell disease.
Helen Rooks, John Brewin, Kate Gardner, Subarna Chakravorty, Stephan Menzel, Anke Hannemann, John Gibson, David C Rees
Feb 18, 2019
The effect of the antisickling compound GBT1118 on the permeability of red blood cells from patients with sickle cell anemia.
Halima Al Balushi, Kobina Dufu, David C Rees, John N Brewin, Anke Hannemann, Donna Oksenberg, David C-Y Lu, John S Gibson
Feb 28, 2019
GBT1118 O2 affinity sickle cell anemia cell volume Hemolysis Potassium permeability sickling Anemia Sickle Cell Antisickling Agents Benzaldehydes Cell Size Erythrocyte Membrane Hemoglobin Sickle Hemolysis Humans Intermediate-Conductance Calcium-Activated Potassium Channels Niacinamide Oxygen Permeability Symporters
Yoda1 and phosphatidylserine exposure in red cells from patients with sickle cell anaemia.
Nanoscale adhesion profiling and membrane characterisation in sickle cell disease using hybrid atomic force microscopy-IR spectroscopy.
The effect of xanthine oxidase and hypoxanthine on the permeability of red cells from patients with sickle cell anemia.
Red cells from patients with sickle cell anemia (SCA) are under greater oxidative challenge than those from normal individuals. We postulated that oxidants generated by xanthine oxidase (XO) and hypoxanthine (HO) contribute to...
Sickle Cell Disorders and Severe COVID-19 Outcomes
Ashley Kieran Clift, Defne Saatci, Carol AC Coupland, Hajira Dambha-Miller, Julia Hippisley-Cox, International Investigator Group for Ethnicity and COVID-19
Jul 26, 2021
Spermatogonial quantity in human prepubertal testicular tissue collected for fertility preservation prior to potentially sterilizing therapy.
J-B Stukenborg, JP Alves-Lopes, M Kurek, H Albalushi, A Reda, V Keros, V Töhönen, R Bjarnason, P Romerius, M Sundin, U Norén Nyström, C Langenskiöld, H Vogt, L Henningsohn, RT Mitchell, O Söder, C Petersen, K Jahnukainen
Dec 04, 2019
STUDY QUESTION: Does chemotherapy exposure (with or without alkylating agents) or primary diagnosis affect spermatogonial quantity in human prepubertal testicular tissue? SUMMARY ANSWER: Spermatogonial quantity is significantly...
The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia.
David C-Y Lu, Anke Hannemann, Rasiqh Wadud, David C Rees, John N Brewin, Philip S Low, John S Gibson
Oct 30, 2019
Processing of positive newborn screening results
Jane Chudleigh, Holly Chinnery, Pru Holder, Rachel S Carling, Kevin Southern, Ellinor Olander, Louise Moody, Stephen Morris, Fiona Ulph, Mandy Bryon, Alan Simpson
Dec 22, 2020
OBJECTIVE: To explore current communication practices for positive newborn screening results from the newborn bloodspot screening (NBS) laboratory to clinicians to highlight differences, understand how the pathways are...
Effects of 5-hydroxymethyl-2-furfural on the volume and membrane permeability of red blood cells from patients with sickle cell disease.
The pleiotropic effects of α-thalassemia on HbSS and HbSC sickle cell disease
John N Brewin, Amina Nardo-Marino, Sara Stuart-Smith, Sara El Hoss, Anke Hanneman, John Strouboulis, Stephan Menzel, John S Gibson, David C Rees
Jul 18, 2022
Higher oxygen saturation with hydroxyurea in paediatric sickle cell disease.
Lisa van Geyzel, Michele Arigliani, Baba Inusa, Bethany Singh, Wanda Kozlowska, Subarna Chakravorty, Cara J Bossley, Gary Ruiz, David Rees, Atul Gupta
Jan 31, 2020
INTRODUCTION: Sickle cell disease (SCD) is one of the most common inherited diseases worldwide. It is associated with lifelong morbidity and reduced life expectancy. Hydroxyurea (HU) has been shown to reduce the frequency and...