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Adenosine A3 Receptor Antagonists Animals Binding Sites Binding Competitive CHO Cells Cricetulus Cyclic AMP Drug Evaluation Preclinical Humans Kinetics Molecular Dynamics Simulation Mutagenesis Site-Directed Radioligand Assay Rats Receptor Adenosine A3 Receptors Purinergic P1 Recombinant Proteins Species Specificity Structure-Activity Relationship

BACKGROUND: LmrA is a multidrug ATP-binding cassette (ABC) transporter from Lactococcus lactis with no known physiological substrate, which can transport a wide range of chemotherapeutic agents and toxins from the cell. The...

ATP-Binding Cassette Transporters Bacterial Proteins Base Sequence DNA Primers Ion Transport Multidrug Resistance-Associated Proteins Mutagenesis Site-Directed Protons Sodium Chloride Spectrometry Mass Electrospray Ionization

AIMS/HYPOTHESIS: Genetic insulin receptoropathies are a rare cause of severe insulin resistance. We identified the Ile119Met missense mutation in the insulin receptor INSR gene, previously reported in a Yemeni kindred, in four...

Adult Africa Cells Cultured Child Female Haplotypes Humans Infant Insulin Resistance Male Mutagenesis Site-Directed Mutation Polymerase Chain Reaction Protein Precursors Receptor Insulin Young Adult

Genetic variants of the inhibitory Fc receptor FcγRIIb have been associated with systemic lupus erythematosus in humans and mice. The mechanism by which Fcgr2b variants contribute to the development of autoimmunity is unknown...

Animals Autoantibodies Autoimmunity B-Lymphocytes Chromatin Immunoprecipitation DNA Primers Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunospot Assay Flow Cytometry Gene Expression Regulation Gene Knock-In Techniques genetic variation Germinal Center Luciferases Mice Mice Inbred C57BL Mutagenesis Site-Directed Promoter Regions Genetic Receptors IgG Sequence Analysis DNA statistics Nonparametric Transcription Factor AP-1

Animals Bacterial Proteins Campylobacter Infections Campylobacter coli Campylobacter jejuni Chickens DNA Transposable Elements Gene Expression Regulation Bacterial Gene Library Genome Bacterial Humans Mutagenesis Site-Directed Mutation Peptidoglycan Poultry Diseases whole genome sequencing

The midbody is an organelle assembled at the intercellular bridge between the two daughter cells at the end of mitosis. It controls the final separation of the daughter cells and has been involved in cell fate, polarity, tissue...

Aurora Kinase B Binding Sites Cytokinesis HeLa Cells Humans Intravital Microscopy Microtubule-Associated Proteins Microtubules Mitosis Mutagenesis Site-Directed Myosin-Light-Chain Phosphatase Phosphorylation Protein Interaction Maps Protein Phosphatase 1 RNA Small Interfering Spindle Apparatus Time-Lapse Imaging

Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but...

allosteric modulation human Ligand-Gated Ion Channels molecular biophysics neuroscience structural biology Bacterial Proteins Binding Sites Erwinia Ligand-Gated Ion Channels Models Molecular Mutagenesis Site-Directed Protein Conformation Receptors Serotonin 5-HT3 Single-Domain Antibodies

The mammalian target of rapamycin (mTOR) is a critical regulator of cell growth, integrating multiple signalling cues and pathways. Key among the downstream activities of mTOR is the control of the protein synthesis machinery....

5' Untranslated Regions Autoantigens Gene Expression Regulation Genes Reporter HeLa Cells Humans Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 Mutagenesis Site-Directed Mutation Missense Naphthyridines Point Mutation Poly(A)-Binding Protein I Polyribosomes Protein Biosynthesis RNA Interference RNA Messenger RNA-Binding Proteins Recombinant Fusion Proteins Ribonucleoproteins TOR Serine-Threonine Kinases