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Results: 9
Liver-heart crosstalk controls IL-22 activity in cardiac protection after myocardial infarction.
Ting-Ting Tang, Yuan-Yuan Li, Jing-Jing Li, Ke Wang, Yue Han, Wen-Yong Dong, Zheng-Feng Zhu, Ni Xia, Shao-Fang Nie, Min Zhang, Zhi-Peng Zeng, Bing-Jie Lv, Jiao Jiao, Heng Liu, Zong-Shu Xian, Xiang-Ping Yang, Yu Hu, Yu-Hua Liao, Qing Wang, Xin Tu, Ziad Mallat, Yu Huang, Guo-Ping Shi, Xiang Cheng
Nov 22, 2018
Interleukin (IL)-22 regulates tissue inflammation and repair. Here we report participation of the liver in IL-22-mediated cardiac repair after acute myocardial infarction (MI). Methods: We induced experimental MI in mice by...
A Multi‑Center, Open‑Label, Single‑Arm Trial to Evaluate the Efficacy, Pharmacokinetics, and Safety and Tolerability of IGSC 20% in Subjects with Primary Immunodeficiency.
Manuel Santamaria, Olaf Neth, Jo A Douglass, Gergely Krivan, Robin Kobbe, Ewa Bernatowska, Sofia Grigoriadou, Claire Bethune, Anita Chandra, Gerd Horneff, Michael Borte, Anja Sonnenschein, Pavlina Kralickova, Silvia Sánchez Ramón, Daman Langguth, Luis Ignacio Gonzalez-Granado, Laia Alsina, Montse Querolt, Rhonda Griffin, Carrie Hames, Elsa Mondou, Jeffrey Price, Ana Sanz, Jiang Lin
Apr 19, 2022
PURPOSE: The purpose of this phase 3 study was to evaluate the efficacy, pharmacokinetics (PK), and safety of Immune Globulin Subcutaneous (Human), 20% Caprylate/Chromatography Purified (IGSC 20%) in patients with primary...
Superior MRI outcomes with alemtuzumab compared with subcutaneous interferon β-1a in MS
DL Arnold, E Fisher, VV Brinar, JA Cohen, AJ Coles, G Giovannoni, H-P Hartung, E Havrdova, KW Selmaj, M Stojanovic, HL Weiner, SL Lake, DH Margolin, DR Thomas, MA Panzara, DAS Compston, CARE-MS I and CARE-MS II Investigators
Jan 06, 2017
Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care.
Lia Bally, Hood Thabit, Sara Hartnell, Eveline Andereggen, Yue Ruan, Malgorzata E Wilinska, Mark L Evans, Maria M Wertli, Anthony P Coll, Christoph Stettler, Roman Hovorka
Sep 20, 2018
BACKGROUND: In patients with diabetes, hospitalization can complicate the achievement of recommended glycemic targets. There is increasing evidence that a closed-loop delivery system (artificial pancreas) can improve glucose...
Safety, efficacy and glucose turnover of reduced prandial boluses during closed-loop therapy in adolescents with type 1 diabetes
D Elleri, M Biagioni, JM Allen, K Kumareswaran, L Leelarathna, K Caldwell, M Nodale, ME Wilinska, A Haidar, P Calhoun, C Kollman, NC Jackson, AM Umpleby, CL Acerini, DB Dunger, R Hovorka
Aug 11, 2015
closed-loop insulin delivery postprandial hypoglycaemia type 1 diabetes Adolescent Algorithms Blood Glucose Cross-Over Studies Diabetes mellitus Type 1 Drug Administration Schedule England Female Glycemic Load Humans Hyperinsulinism Hypoglycemia Hypoglycemic Agents Injections Subcutaneous Insulin Insulin Infusion Systems Insulin Resistance Male Meals Monitoring Physiologic risk
6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE)
Helena M Earl, Louise Hiller, Anne-Laure Vallier, Shrushma Loi, Karen McAdam, Luke Hughes-Davies, Adrian N Harnett, Mei-Lin Ah-See, Richard Simcock, Daniel Rea, Sanjay Raj, Pamela Woodings, Mark Harries, Donna Howe, Kerry Raynes, Helen B Higgins, Maggie Wilcox, Chris Plummer, Janine Mansi, Ioannis Gounaris, Betania Mahler-Araujo, Elena Provenzano, Anita Chhabra, Jean E Abraham, Carlos Caldas, Peter S Hall, Christopher McCabe, Claire Hulme, David Miles, Andrew M Wardley, David A Cameron, Janet A Dunn, PERSEPHONE Steering Committee and Trial Investigators
Mar 08, 2019
Adult Aged Aged 80 and over Antineoplastic Agents Immunological Breast Neoplasms Chemotherapy Adjuvant Disease-Free Survival Drug Administration Schedule Female Humans Infusions Intravenous Injections Subcutaneous Middle Aged Prospective Studies Receptor ErbB-2 Trastuzumab Treatment Outcome United Kingdom Young Adult
Continuous subcutaneous infusion in palliative care
Syringe drivers are widely used in palliative care, and this article reviews the challenges and outstanding questions associated with their use. Misperceptions among the lay public and some health professionals can be addressed...
A randomized, multicentre trial evaluating the efficacy and safety of fast-acting insulin aspart in continuous subcutaneous insulin infusion in adults with type 1 diabetes (onset 5).
David C Klonoff, Mark L Evans, Wendy Lane, Hans-Peter Kempe, Eric Renard, J Hans DeVries, Tina Graungaard, Agon Hyseni, Theis Gondolf, Tadej Battelino
Jan 02, 2019
Evaluating Glucose Control With a Novel Composite Continuous Glucose Monitoring Index.
Lalantha Leelarathna, Hood Thabit, Malgorzata E Wilinska, Lia Bally, Julia K Mader, Thomas R Pieber, Carsten Benesch, Sabine Arnolds, Terri Johnson, Lutz Heinemann, Norbert Hermanns, Mark L Evans, Roman Hovorka
Feb 19, 2019
OBJECTIVE: The objective was to describe a novel composite continuous glucose monitoring index (COGI) and to evaluate its utility, in adults with type 1 diabetes, during hybrid closed-loop (HCL) therapy and multiple daily...
closed-loop insulin delivery Continuous glucose monitoring type 1 diabetes Adult Blood Glucose Blood Glucose Self-Monitoring Diabetes mellitus Type 1 Drug Administration Schedule Female Glycated Hemoglobin glycemic control Health Status Indicators Humans Injections Subcutaneous Insulin Insulin Infusion Systems Male Monitoring Physiologic Prognosis Retrospective Studies Time Factors Treatment Outcome