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Results: 10
Maternal iron deficiency perturbs embryonic cardiovascular development in mice.
Jacinta I Kalisch-Smith, Nikita Ved, Dorota Szumska, Jacob Munro, Michael Troup, Shelley E Harris, Helena Rodriguez-Caro, Aimée Jacquemot, Jack J Miller, Eleanor M Stuart, Magda Wolna, Emily Hardman, Fabrice Prin, Eva Lana-Elola, Rifdat Aoidi, Elizabeth MC Fisher, Victor LJ Tybulewicz, Timothy J Mohun, Samira Lakhal-Littleton, Sarah De Val, Eleni Giannoulatou, Duncan B Sparrow
Jul 28, 2021
Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero...
Animals Aorta Thoracic Biomarkers cardiovascular system Cell Differentiation Coronary Vessels Dietary Supplements Edema Embryo Mammalian Embryonic Development Female Gene Expression Profiling Gene-Environment Interaction Green Fluorescent Proteins Iron Iron Deficiencies Lymphatic Vessels Mice Inbred C57BL Myocardium Myocytes Cardiac Penetrance Phenotype Pregnancy Signal Transduction Stem Cells Transgenes Tretinoin
Chest CT in patients after lung transplantation
Alexander Wressnegger, Helmut Prosch, Bernhard Moser, Walter Klepetko, Peter Jaksch, Christopher Lambers, Konrad Hoetzenecker, Christian Schestak, Albert De Bettignies, Lucian Beer, Georg Apfaltrer, Helmut Ringl, Paul Apfaltrer
Apr 03, 2020
OBJECTIVES: The purpose of this study was to investigate the impact of a 150kV spectral filtration chest imaging protocol (Sn150kVp) combined with advanced modeled iterative reconstruction (ADMIRE) on radiation dose and image...
Algorithms Female Humans Image Processing Computer-Assisted Lung Diseases Lung Transplantation Male Middle Aged Radiation Dosage Radiographic Image Enhancement Radiographic Image Interpretation Computer-Assisted Radiography Thoracic Retrospective Studies Signal-To-Noise Ratio tin Tomography X-Ray Computed
Editor's Choice - Calcification of Thoracic and Abdominal Aneurysms is Associated with Mortality and Morbidity.
Mohammed M Chowdhury, Lukasz P Zieliński, James J Sun, Simon Lambracos, Jonathan R Boyle, Seamus C Harrison, James HF Rudd, Patrick A Coughlin
Mar 02, 2018
INTRODUCTION: Cardiovascular events are common in people with aortic aneurysms. Arterial calcification is a recognised predictor of cardiovascular outcomes in coronary artery disease. Whether calcification within abdominal and...
Atherosclerosis calcification Computed tomography Thoracic abdominal aortic aneurysm Aged Aged 80 and over Aortic Aneurysm Abdominal Aortic Aneurysm Thoracic Computed Tomography Angiography Female Humans Male Odds Ratio Retrospective Studies Risk Assessment Tomography X-Ray Computed Vascular Calcification
Pulmonary Aspergillosis in Patients with Suspected Ventilator-associated Pneumonia in UK ICUs.
Laura Loughlin, Thomas P Hellyer, P Lewis White, Danny F McAuley, Andrew Conway Morris, Raquel B Posso, Malcolm D Richardson, David W Denning, A John Simpson, Ronan McMullan
Jul 06, 2020
Rationale:Aspergillus infection in patients with suspected ventilator-associated pneumonia remains uncharacterized because of the absence of a disease definition and limited access to sensitive diagnostic tests.Objectives: To...
Aspergillus Critical Care Diagnostic Tests prevalence Adult Age Distribution Aged Aspergillus Cohort Studies Comorbidity Critical Care Critical Illness DNA Fungal Female Follow-Up Studies Humans Intensive Care Units Male Middle Aged Pneumonia Ventilator-Associated Polymerase Chain Reaction prevalence Prospective Studies Pulmonary Aspergillosis Radiography Thoracic Risk Assessment Sex Distribution statistics Nonparametric United Kingdom
Influence of overlapping pattern of multiple overlapping uncovered stents on the local mechanical environment
Shuo Wang, Yongxue Zhang, Jiaxuan Feng, Yuan Huang, Aziz Tokgoz, Umar Sadat, Jonathan H Gillard, Qingsheng Lu, Zhongzhao Teng
Jul 13, 2017
In vivo alpha-V beta-3 integrin expression in human aortic atherosclerosis.
William S Jenkins, Alex T Vesey, Anna Vickers, Anoushka Neale, Catriona Moles, Martin Connell, Nikhil Vilas Joshi, Christophe Lucatelli, Alison M Fletcher, James C Spratt, Saeed Mirsadraee, Edwin JR van Beek, James HF Rudd, David E Newby, Marc R Dweck
Jul 24, 2019
OBJECTIVES: Intraplaque angiogenesis and inflammation are key promoters of atherosclerosis and are mediated by the alpha-V beta-3 (αvβ3) integrin pathway. We investigated the applicability of the αvβ3-integrin receptor-selective...
Atherosclerosis Computed tomography integrin positron emission tomography Aged Aorta Thoracic Aortic Diseases Atherosclerosis Carboxylic Acids Carotid Stenosis Cyclobutanes Female Humans Image Interpretation Computer-Assisted Integrin alphaVbeta3 Male Middle Aged Myocardial Infarction Positron Emission Tomography Computed Tomography Radiopharmaceuticals Vascular Calcification
Role of Microvascular Tone and Extracellular Matrix Contraction in the Regulation of Interstitial Fluid
The pathophysiology of aortic dissection is poorly understood, and its risk is resistant to medical treatment. Most studies have focused on a proposed pathogenic role of transforming growth factor-β in Marfan disease and related...
actin Aneurysm Extracellular Fluid pericyte vasa vasorum aortic dissection Animals Aorta Thoracic Aortic Aneurysm Thoracic Dilatation Pathologic Extracellular Fluid Extracellular Matrix Gene Expression Regulation Genetic Predisposition to Disease Humans Mechanotransduction Cellular Microcirculation Microvessels Models Biological Models Cardiovascular Pressure Vasoconstriction
Estimating central blood pressure from aortic flow
Jorge Mariscal-Harana, Peter H Charlton, Samuel Vennin, Jorge Aramburu, Mateusz Cezary Florkow, Arna van Engelen, Torben Schneider, Hubrecht de Bliek, Bram Ruijsink, Israel Valverde, Philipp Beerbaum, Heynric Grotenhuis, Marietta Charakida, Phil Chowienczyk, Spencer J Sherwin, Jordi Alastruey
Oct 26, 2020
Central blood pressure (cBP) is a highly prognostic cardiovascular (CV) risk factor whose accurate, invasive assessment is costly and carries risks to patients. We developed and assessed novel algorithms for estimating cBP from...
Radiological staging in breast cancer
BACKGROUND: Approximately 4% of patients diagnosed with early breast cancer have occult metastases at presentation. Current national and international guidelines lack consensus on whom to image and how. METHODS: We assessed...
Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients.
Xiaoke Yin 殷晓科, Shaynah Wanga, Adam L Fellows, Javier Barallobre-Barreiro, Ruifang Lu, Hongorzul Davaapil, Romy Franken, Marika Fava, Ferheen Baig, Philipp Skroblin, Qiuru Xing, David R Koolbergen, Maarten Groenink, Aeilko H Zwinderman, Ron Balm, Carlie JM de Vries, Barbara JM Mulder, Rosa Viner, Marjan Jahangiri, Dieter P Reinhardt, Sanjay Sinha, Vivian de Waard, Manuel Mayr
Jul 25, 2019
OBJECTIVE: Marfan syndrome (MFS) is caused by mutations in FBN1 (fibrillin-1), an extracellular matrix (ECM) component, which is modified post-translationally by glycosylation. This study aimed to characterize the glycoproteome...